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Provide AlphaMissense as a prediction score #1138

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xiamaz opened this issue Sep 20, 2023 · 1 comment
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Provide AlphaMissense as a prediction score #1138

xiamaz opened this issue Sep 20, 2023 · 1 comment
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enhancement New feature or request

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@xiamaz
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xiamaz commented Sep 20, 2023

A recent paper by Jun Cheng et al has published a missense prediction model using AlphaFold. The trained model has not been made public, but AA substitution predictions for all missense variants in hg19 and hg38 have been provided publicly: https://console.cloud.google.com/storage/browser/dm_alphamissense;tab=objects?pli=1&prefix=&forceOnObjectsSortingFiltering=false

Jun Cheng et al. ,Accurate proteome-wide missense variant effect prediction with AlphaMissense.Science0,eadg7492DOI:10.1126/science.adg7492

@xiamaz xiamaz added the enhancement New feature or request label Sep 20, 2023
@holtgrewe
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Subsumed in #1300

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