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idea/question (estimating gene mutation) #100

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muntajihad opened this issue Oct 7, 2024 · 0 comments

muntajihad commented Oct 7, 2024

Hi there,
Firstly, many thanks for developing such a nice tool.

I have an idea and would like to discuss it with you to see the applicability of using scGEN.

I have scRNA-seq mouse data of 2 conditions (4 WT, 4 specific gene KO).
I have human scRNA-seq data of 20 samples (genetic background unknown). However, some samples might have a gene mutation similar to KO in mice data.

Is it possible to train scGEN on mouse data and then use it on human data to estimate which samples have that mutation and which don't?

Best,

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