Overview

Overview:

The METATRYP tools are intended to help researchers answer questions about proteomics data.

Some specific questions that these tools help provide answers for include:

• Is tryptic peptide XXX found in Proteome A and Proteome B?
• How many tryptic peptides do Proteome A and Proteome B have in common?
• Are tryptic peptides XXX and YYY both found in Proteome A?
• How many tryptic peptides are there in Proteome A that differ from peptide XXX by n positions?

Please note that this is not designed as a high-performance/high-volume solution; Instead it is intended to function as a quick-and-easy testing bed for doing computational analyses of proteomics data.

For higher volume instance of the METATRYP software with additional features (like Lowest Common Ancestor Analysis), please see METATRYP v. 2(https://github.com/WHOIGit/metatryp-2.0). A web portal using a marine microbe database can be found at https://metatryp.whoi.edu/, and a portal using a coronavirus focused database can be found at https://metatryp-coronavirus.whoi.edu/.

When using METATRYP v. 1 please cite the following:
Saito, M.A., Dorsk, A., Post, A.F., McIlvin, M.R., Rappé, M.S., DiTullio, G.R. and Moran, D.M. (2015), Needles in the blue sea: Sub‐species specificity in targeted protein biomarker analyses within the vast oceanic microbial metaproteome. Proteomics, 15: 3521-3531. doi:10.1002/pmic.201400630