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Update README
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LucieContamin authored Jun 10, 2024
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Expand Up @@ -223,6 +223,23 @@ November 2020-April 2021.
[Cybersecurity and Infrastructure Security Agency](https://www.cisa.gov/sites/default/files/publications/ECIW_4.0_Guidance_on_Essential_Critical_Infrastructure_Workers_Final3_508_0.pdf).


- VE assumptions: Three vaccines were authorized in the United States: (1) BNT162b2 mRNA
from Pfizer/BioNTech; (2) mRNA-1273 from Moderna; and (3) Ad26.COV2.S from Janssen.
The efficacy of vaccines against symptomatic infection was 95%, 94%, and 66% for the BNT162b2,
mRNA-1273, and Ad26.COV2.S vaccines respectively against the Wuhan and B.1.1.7 strains,
with even greater efficacy against hospitalization and death (
[Lindsey R. Baden et al. 2020](https://www.nejm.org/doi/full/10.1056/nejmoa2035389),
[Fernando P. Polack et al. 2020](https://www.nejm.org/doi/full/10.1056/nejmoa2034577),
[Jerald Sadoff et al. 2021](https://pubmed.ncbi.nlm.nih.gov/33882225/),
[Sara E. Oliver et al. 2020](https://www.cdc.gov/mmwr/volumes/69/wr/mm6950e2.htm?fbclid=IwAR1-k3Zmjw3E-wcewxeX03yqdbrj3BROSJuaNhLS5fm_zfIfLlJMcH6Hcaw)). Ad26.COV2.S
from Janssen was not administered in the US until Feb 27, 2021, so it can be assumed it had
minimal impact during this study period ([Janssen COVID-19 Vaccine FDA Approval Status](https://www.drugs.com/history/janssen-covid-19-vaccine.html#:~:text=On%20February%2027%2C%202021%2C%20the,years%20of%20age%20and%20older.)).

- Teams are free to ignore the impact of waning given that most individuals would be vaccinated
within 4 months of the projection end date. We can assume that VE is 95% after two doses, 50%
after one dose, and that doses typically occur 3.5 weeks apart. Teams would maintain these VE
estimates for the duration of the study period.

### Calibration Data


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