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Fix Heilmann22 (#962)
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* Fix Heilmann22

* Remove duplicates

* remove blank lines

* Fix Heilmann22

* update unclassified rx
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@KaimingTao
KaimingTao authored Sep 18, 2023
1 parent 47b4c67 commit dea6db2
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Showing 6 changed files with 46 additions and 38 deletions.
76 changes: 38 additions & 38 deletions tables/invitro_selection_results/heilmann22-invitro.csv
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@@ -1,40 +1,40 @@
ref_name,rx_name,backbone,gene,position,amino_acid,section,date_added
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,2,V,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,3,S,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,32,I,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,54,C,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,54,S,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,80,P,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,98,I,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,99,L,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,118,H,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,126,F,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,127,R,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,128,Y,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,138,S,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,141,F,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,167,F,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,192,R,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,194,S,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,197,Y,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,200,T,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,202,F,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,203,D,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,203,H,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,203,K,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,203,S,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,204,F,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,208,W,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,216,G,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,216,Y,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,219,S,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,222,Q,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,295,G,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,295,N,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,295,Y,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,296,G,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,298,G,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,299,K,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,299,P,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,305,L,Table S1,2022-11-10
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,216,Y,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,2,V,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,295,Y,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,3,S,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,32,I,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,80,P,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,216,G,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,167,F,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,204,F,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,54,C,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,54,S,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,299,P,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,118,H,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,194,S,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,219,S,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,197,Y,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,295,G,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,295,N,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,138,S,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,208,W,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,203,D,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,203,H,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,203,K,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,203,S,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,192,R,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,299,K,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,298,G,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,128,Y,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,202,F,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,296,G,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,98,I,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,99,L,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,127,R,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,305,L,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,3CLpro:F305L,_3CLpro,200,T,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,126,F,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,141,F,Table S1,2023-09-18
Heilmann22,Nirmatrelvir,Wuhan-Hu-1,_3CLpro,222,Q,Table S1,2023-09-18
Heilmann22,GC376,Wuhan-Hu-1,_3CLpro,305,L,"Results section, para. 3",2022-11-10
1 change: 1 addition & 0 deletions tables/isolate_mutations.csv
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Expand Up @@ -25018,3 +25018,4 @@ BA.2.86 Spike,S,939,F,NULL,NULL
BA.2.86 Spike,S,954,H,NULL,NULL
BA.2.86 Spike,S,969,K,NULL,NULL
BA.2.86 Spike,S,1143,L,NULL,NULL
3CLpro:F305L,_3CLpro,305,L,NULL,NULL
1 change: 1 addition & 0 deletions tables/isolates.csv
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Expand Up @@ -1630,3 +1630,4 @@ Omicron/XBB.1.5 full genome,Omicron/XBB.1.5,FALSE,NULL,NULL,NULL,TRUE
3CLpro:D48N,NULL,FALSE,NULL,NULL,NULL,TRUE
Omicron/BA.2.86 full genome,Omicron/BA.2.86,FALSE,NULL,NULL,TRUE,TRUE
BA.2.86 Spike,Omicron/BA.2.86,FALSE,NULL,NULL,TRUE,TRUE
3CLpro:F305L,NULL,FALSE,NULL,NULL,NULL,TRUE
4 changes: 4 additions & 0 deletions tables/rx_potency/heilmann22-pot.csv
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Expand Up @@ -26,3 +26,7 @@ Heilmann22,Ensitrelvir,Wuhan-Hu-1,Table S8,Pseudovirus (VSV),EC50,8,1,100,0.1,µ
Heilmann22,Ensitrelvir,3CLpro:Y54C,Table S8,Pseudovirus (VSV),EC50,25,1,100,0.1,µM,2022-11-07
Heilmann22,Ensitrelvir,3CLpro:L167F,Table S8,Pseudovirus (VSV),EC50,41.6,1,100,0.1,µM,2022-11-07
Heilmann22,Ensitrelvir,3CLpro:Q192R,Table S8,Pseudovirus (VSV),EC50,25.5,1,100,0.1,µM,2022-11-07
Heilmann22,FRET substrate,Wuhan-Hu-1,Table S9,FRET,Kcat/Km,43200,1,NULL,NULL,s⁻¹M⁻¹,2023-09-18
Heilmann22,FRET substrate,3CLpro:Y54C,Table S9,FRET,Kcat/Km,12100,1,NULL,NULL,s⁻¹M⁻¹,2023-09-18
Heilmann22,FRET substrate,3CLpro:L167F,Table S9,FRET,Kcat/Km,13100,1,NULL,NULL,s⁻¹M⁻¹,2023-09-18
Heilmann22,FRET substrate,3CLpro:Q192R,Table S9,FRET,Kcat/Km,6300,1,NULL,NULL,s⁻¹M⁻¹,2023-09-18
1 change: 1 addition & 0 deletions tables/treatments.csv
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Expand Up @@ -38217,3 +38217,4 @@ Sacco22,FRET substrate
Lin23,FRET substrate
Chaguza23,IVIG
Flynn23,FRET substrate
Heilmann22,FRET substrate
1 change: 1 addition & 0 deletions tables/unclassified-rx.csv
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Expand Up @@ -26,3 +26,4 @@ Sacco22,FRET substrate
Lin23,FRET substrate
Chaguza23,IVIG
Flynn23,FRET substrate
Heilmann22,FRET substrate

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