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add Kiso23b - 10.1038/s41467-023-40018-1, Fix #938 (#947)
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* add Kiso23b - 10.1038/s41467-023-40018-1, Fix #938

* Fix Kiso23b

* Autogenerated data updated by HIVDB Bot

---------

Co-authored-by: HIVDB Bot <[email protected]>
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@KaimingTao @hivdb-bot
KaimingTao and hivdb-bot authored Aug 16, 2023
1 parent 847b2cf commit 2443c35
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Showing 8 changed files with 74 additions and 0 deletions.
1 change: 1 addition & 0 deletions tables/articles.csv
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Expand Up @@ -786,3 +786,4 @@ Wu23,10.1016/j.ccell.2023.04.005,NULL,"Wu, M",2023,2023-06-27,NULL
Kiso23,10.1038/s41467-023-39704-x,NULL,"Kiso, M",2023,2023-08-15,NULL
Jiang23,10.1021/acs.biochem.3c00075,NULL,"Jiang, H",2023,2023-08-16,NULL
Iketani23,10.1101/2022.06.23.497404,NULL,"Iketani, S",2023,2023-08-16,NULL
Kiso23b,10.1038/s41467-023-40018-1,NULL,"Kiso, M",2023,2023-08-15,NULL
3 changes: 3 additions & 0 deletions tables/invitro_selection_results/kiso23b-invitro.csv
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ref_name,rx_name,backbone,gene,position,amino_acid,section,date_added
Kiso23b,Ensitrelvir,hCoV-19/USA/WI-UW-5250/2021,_3CLpro,49,L,Result,2023-08-16
Kiso23b,Ensitrelvir,hCoV-19/USA/WI-UW-5250/2021,_3CLpro,166,A,Result,2023-08-16
37 changes: 37 additions & 0 deletions tables/isolate_mutations.csv
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Expand Up @@ -4942,6 +4942,43 @@ hCoV-19/USA/WI-UW-5250/2021,S,478,K,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021,S,614,G,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021,S,681,R,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021,S,950,N,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,S,19,R,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,S,95,I,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,S,142,D,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,S,156,G,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,S,157,del,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,S,158,del,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,S,452,R,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,S,478,K,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,S,614,G,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,S,681,R,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,S,950,N,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,_3CLpro,49,L,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,S,19,R,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,S,95,I,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,S,142,D,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,S,156,G,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,S,157,del,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,S,158,del,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,S,452,R,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,S,478,K,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,S,614,G,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,S,681,R,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,S,950,N,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,_3CLpro,166,A,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,S,19,R,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,S,95,I,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,S,142,D,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,S,156,G,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,S,157,del,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,S,158,del,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,S,452,R,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,S,478,K,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,S,614,G,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,S,681,R,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,S,950,N,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,_3CLpro,49,L,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,_3CLpro,166,A,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:L50F+E166V,S,19,R,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:L50F+E166V,S,95,I,NULL,NULL
hCoV-19/USA/WI-UW-5250/2021+nsp5:L50F+E166V,S,142,D,NULL,NULL
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3 changes: 3 additions & 0 deletions tables/isolates.csv
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Expand Up @@ -992,6 +992,9 @@ S:63del+64del+65del+66del+67del+68del+69del+70del+71del+72del+73del+74del+75del+
hCoV-19/Japan/QHN001/2020,Alpha,FALSE,804007,NULL,NULL,TRUE
hCoV-19/USA/CA-Stanford-15_S02/2021,Kappa,FALSE,1675223,NULL,NULL,TRUE
hCoV-19/USA/WI-UW-5250/2021,Delta,FALSE,NULL,NULL,NULL,TRUE
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,Delta,FALSE,NULL,NULL,NULL,TRUE
hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,Delta,FALSE,NULL,NULL,NULL,TRUE
hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,Delta,FALSE,NULL,NULL,NULL,TRUE
hCoV-19/USA/WI-UW-5250/2021+nsp5:L50F+E166V,Delta,FALSE,NULL,NULL,NULL,TRUE
hCoV-19/USA/WI-UW-5250/2021+nsp5:L50F+E166A+L167F,Delta,FALSE,NULL,NULL,NULL,TRUE
England/MIG457/2020,Alpha,FALSE,NULL,NULL,NULL,TRUE
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4 changes: 4 additions & 0 deletions tables/ref_isolate_pairs/kiso23b-pair.csv
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@@ -0,0 +1,4 @@
ref_name,control_iso_name,iso_name
Kiso23b,hCoV-19/USA/WI-UW-5250/2021,hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L
Kiso23b,hCoV-19/USA/WI-UW-5250/2021,hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A
Kiso23b,hCoV-19/USA/WI-UW-5250/2021,hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A
5 changes: 5 additions & 0 deletions tables/rx_compounds/koso23b-drug.csv
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@@ -0,0 +1,5 @@
ref_name,rx_name,drug_name
Kiso23b,Nirmatrelvir,Nirmatrelvir
Kiso23b,Molnupiravir,Molnupiravir
Kiso23b,Remdesivir,Remdesivir
Kiso23b,Ensitrelvir,Ensitrelvir
17 changes: 17 additions & 0 deletions tables/rx_potency/kiso23b-pot.csv
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@@ -0,0 +1,17 @@
ref_name,rx_name,iso_name,section,assay_name,potency_type,potency,cumulative_count,potency_upper_limit,potency_lower_limit,potency_unit,date_added
Kiso23b,Ensitrelvir,hCoV-19/USA/WI-UW-5250/2021,Table 1,Virus isolate,EC50,0.19,1,100,0.1,µM,2023-08-16
Kiso23b,Ensitrelvir,hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,Table 1,Virus isolate,EC50,11.6,1,100,0.1,µM,2023-08-16
Kiso23b,Ensitrelvir,hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,Table 1,Virus isolate,EC50,1.72,1,100,0.1,µM,2023-08-16
Kiso23b,Ensitrelvir,hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,Table 1,Virus isolate,EC50,37.4,1,100,0.1,µM,2023-08-16
Kiso23b,Nirmatrelvir,hCoV-19/USA/WI-UW-5250/2021,Table 1,Virus isolate,EC50,8.63,1,100,0.1,µM,2023-08-16
Kiso23b,Nirmatrelvir,hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,Table 1,Virus isolate,EC50,3.26,1,100,0.1,µM,2023-08-16
Kiso23b,Nirmatrelvir,hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,Table 1,Virus isolate,EC50,11.2,1,100,0.1,µM,2023-08-16
Kiso23b,Nirmatrelvir,hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,Table 1,Virus isolate,EC50,8.19,1,100,0.1,µM,2023-08-16
Kiso23b,Molnupiravir,hCoV-19/USA/WI-UW-5250/2021,Table 1,Virus isolate,EC50,3.31,1,100,0.1,µM,2023-08-16
Kiso23b,Molnupiravir,hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,Table 1,Virus isolate,EC50,13.1,1,100,0.1,µM,2023-08-16
Kiso23b,Molnupiravir,hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,Table 1,Virus isolate,EC50,13.5,1,100,0.1,µM,2023-08-16
Kiso23b,Molnupiravir,hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,Table 1,Virus isolate,EC50,10.21,1,100,0.1,µM,2023-08-16
Kiso23b,Remdesivir,hCoV-19/USA/WI-UW-5250/2021,Table 1,Virus isolate,EC50,0.83,1,100,0.1,µM,2023-08-16
Kiso23b,Remdesivir,hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L,Table 1,Virus isolate,EC50,2.64,1,100,0.1,µM,2023-08-16
Kiso23b,Remdesivir,hCoV-19/USA/WI-UW-5250/2021+nsp5:E166A,Table 1,Virus isolate,EC50,2.58,1,100,0.1,µM,2023-08-16
Kiso23b,Remdesivir,hCoV-19/USA/WI-UW-5250/2021+nsp5:M49L+E166A,Table 1,Virus isolate,EC50,2.88,1,100,0.1,µM,2023-08-16
4 changes: 4 additions & 0 deletions tables/treatments.csv
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Expand Up @@ -38100,6 +38100,10 @@ Kiso23,Nirmatrelvir
Kiso23,Molnupiravir
Kiso23,Remdesivir
Kiso23,Ensitrelvir
Kiso23b,Nirmatrelvir
Kiso23b,Molnupiravir
Kiso23b,Remdesivir
Kiso23b,Ensitrelvir
Lan23,Remdesivir
Lan23,Nirmatrelvir
Lan23,GC376
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