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XBB.2.7 + S:T478Q and S:Y453F after Orf1a:E250D. 11 sequences India, England, Denmark, Singapore and Scotland #1725
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2 new sequences from Scotland uploaded today. |
And both with the T-cell-escape mutation S:P272L. |
Thx @ryhisner didnt give a deep look at them, but luckily there are you! |
Sorry it was mistakenly closed by me |
Yep, I've also noticed this one. Thanks for tracking. I think the best is to designate the parent polytomy for now while it's so slow. That helps tracking. |
11 sequences as today. it doesnt seem to compete with 486P stuff. |
Designated the parent branch as XBB.2.7 |
I was routinely checking S:Y453F when i found this little sublineage of XBB.2 with some further AA substitutions.
Defining mutations:
XBB.2 > > orf1a:R3662H (G11250A )> Orf1a:E250D (A1015C), C20316T > C12400T, S:Y453F (A22920T), S:T478Q (A22994C) >
Usher tree:
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice3_genome_29bcb_36bf80.json?c=gt-S_453,478&label=id:node_7740829
CovSpectrum &Gisaid Query: Spike_T478Q,Spike_Y453F
Sequences: 7 ( First ones from India Kerala and Karnataka, last from Denmark)
EPI_ISL_16737817, EPI_ISL_16847536, EPI_ISL_16847543,
EPI_ISL_16888187, EPI_ISL_17017523, EPI_ISL_17048560,
EPI_ISL_17048580
Composite fitness predicted by Nextclade is very high, as expected for increased binding by S:Y453F
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