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Update ReadMe.md #15

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Apr 16, 2024
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Update ReadMe.md #15

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388188c
Update ReadMe.md
conorheffron Apr 15, 2024
8a4e923
Create proof-html.yml
conorheffron Apr 15, 2024
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11 changes: 11 additions & 0 deletions .github/workflows/proof-html.yml
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name: Proof HTML
on:
push:
workflow_dispatch:
jobs:
build:
runs-on: ubuntu-latest
steps:
- uses: anishathalye/[email protected]
with:
directory: ./
2 changes: 2 additions & 0 deletions ReadMe.md
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![Proof HTML](https://github.com/conorheffron/gene-expr/actions/workflows/proof-html.yml/badge.svg)

### Summary

- In this report, I will analyse a publicly available dataset based on clinical breast cancer data. Breast cancer is the most diagnosed cancer in women. There are several subtypes of diseases characterized by different genetic drivers for cancer risk and tumour growth. The human epidermal growth factor receptor 2 amplified (HER2: ERBB2 / ERBB2IP) breast cancer is one of the most aggressive subtypes. In addition, I will investigate HER3 (ERBB3), HER4 (ERBB4), PIK3C2B, MDM4, LRRN2, NFASC, KLHDC8A, and CDK18 gene mutations. Although there are targeted therapies that have been developed to treat these cancer cases, the response rate ranges from 40% - 50%. I will download, decompress, clean and process the TCGA RNASeq data for breast cancer from cbioportal and identify the differentially expressed genes between ERBB2 / ERBB2IP, ERBB3, ERBB4, PIK3C2B, MDM4, LRRN2, NFASC, KLHDC8A, and CDK18 cancer tumours.
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