Skip to content

Commit

Permalink
Merge pull request #14 from conorheffron/doc-a
Browse files Browse the repository at this point in the history
Update ReadMe.md
  • Loading branch information
conorheffron authored Apr 12, 2024
2 parents 484710d + 70d5be3 commit fe4c614
Showing 1 changed file with 2 additions and 4 deletions.
6 changes: 2 additions & 4 deletions ReadMe.md
Original file line number Diff line number Diff line change
Expand Up @@ -3,8 +3,6 @@
- In this report, I will analyse a publicly available dataset based on clinical breast cancer data. Breast cancer is the most diagnosed cancer in women. There are several subtypes of diseases characterized by different genetic drivers for cancer risk and tumour growth. The human epidermal growth factor receptor 2 amplified (HER2: ERBB2 / ERBB2IP) breast cancer is one of the most aggressive subtypes. In addition, I will investigate HER3 (ERBB3), HER4 (ERBB4), PIK3C2B, MDM4, LRRN2, NFASC, KLHDC8A, and CDK18 gene mutations. Although there are targeted therapies that have been developed to treat these cancer cases, the response rate ranges from 40% - 50%. I will download, decompress, clean and process the TCGA RNASeq data for breast cancer from cbioportal and identify the differentially expressed genes between ERBB2 / ERBB2IP, ERBB3, ERBB4, PIK3C2B, MDM4, LRRN2, NFASC, KLHDC8A, and CDK18 cancer tumours.
- The dataset can be downloaded from this [link](https://www.cbioportal.org/study/summary?id=brca_tcga_pan_can_atlas_2018)

### **Run All Code Chunks in _`assignment-2.qmd`_ from RStudio project**
**Run All Code Chunks in _`assignment-2.qmd`_ from RStudio project & render to PDF or HTML**

#### **Render PDF or HTML**

### See full report in html or pdf format at: [Full Report](https://conorheffron.github.io/gene-expr/assignment-2.html)
- See full report in html or pdf format at: [Full Report](https://conorheffron.github.io/gene-expr/assignment-2.html)

0 comments on commit fe4c614

Please sign in to comment.