Respect build constraints for uv run --with dependencies

crates/uv/src/commands/project/run.rs

@@ -894,13 +894,17 @@ hint: If you are running a script with `{}` in the shebang, you may need to incl
         Some(spec) => {
             debug!("Syncing ephemeral requirements");
 
+            // Read the build constraints from the lock file.
+            let build_constraints = lock
+                .as_ref()
+                .map(|(lock, path)| lock.build_constraints(path));
+
             let result = CachedEnvironment::from_spec(
                 EnvironmentSpecification::from(spec).with_lock(
                     lock.as_ref()
                         .map(|(lock, install_path)| (lock, install_path.as_ref())),
                 ),
-                // TODO(bluefact): Respect build constraints for `uv run --with` dependencies.
-                Constraints::default(),
+                build_constraints.unwrap_or_default(),
                 &base_interpreter,
                 &settings,
                 &network_settings,

crates/uv/tests/it/run.rs

@@ -1266,6 +1266,81 @@ fn run_with() -> Result<()> {
     Ok(())
 }
 
+#[test]
+fn run_with_build_constraints() -> Result<()> {
+    let context = TestContext::new("3.8");
+
+    let pyproject_toml = context.temp_dir.child("pyproject.toml");
+    pyproject_toml.write_str(indoc! { r#"
+        [project]
+        name = "foo"
+        version = "1.0.0"
+        requires-python = ">=3.8"
+        dependencies = ["anyio"]
+
+        [tool.uv]
+        build-constraint-dependencies = ["setuptools==1"]
+        "#
+    })?;
+
+    let test_script = context.temp_dir.child("main.py");
+    test_script.write_str(indoc! { r"
+        import os
+       "
+    })?;
+
+    // Installing requests with incompatible build constraints should fail.
+    uv_snapshot!(context.filters(), context.run().arg("--with").arg("requests==1.2").arg("main.py"), @r###"
+    success: false
+    exit_code: 1
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 6 packages in [TIME]
+    Prepared 5 packages in [TIME]
+    Installed 5 packages in [TIME]
+     + anyio==4.3.0
+     + exceptiongroup==1.2.0
+     + idna==3.6
+     + sniffio==1.3.1
+     + typing-extensions==4.10.0
+    Resolved 1 package in [TIME]
+      × Failed to download and build `requests==1.2.0`
+      ├─▶ Failed to resolve requirements from `setup.py` build
+      ├─▶ No solution found when resolving: `setuptools>=40.8.0`
+      ╰─▶ Because you require setuptools>=40.8.0 and setuptools==1, we can conclude that your requirements are unsatisfiable.
+    "###);
+
+    // Change the build constraint to be compatible with `requests==1.2`.
+    pyproject_toml.write_str(indoc! { r#"
+        [project]
+        name = "foo"
+        version = "1.0.0"
+        requires-python = ">=3.8"
+        dependencies = ["anyio"]
+
+        [tool.uv]
+        build-constraint-dependencies = ["setuptools>=42"]
+        "#
+    })?;
+
+    uv_snapshot!(context.filters(), context.run().arg("--with").arg("requests==1.2").arg("main.py"), @r###"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 6 packages in [TIME]
+    Audited 5 packages in [TIME]
+    Resolved 1 package in [TIME]
+    Prepared 1 package in [TIME]
+    Installed 1 package in [TIME]
+     + requests==1.2.0
+    "###);
+
+    Ok(())
+}
+
 /// Sync all members in a workspace.
 #[test]
 fn run_in_workspace() -> Result<()> {