docs(ip-questionable): preserve YouTube AI co-scientist + Robin video VERBATIM 2026-05-28 — Aaron 'exactly what we are doing but times 10 missing a few step' framing + 7 substrate-engineering candidate gaps (Aaron-authorized)#5762
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…-agent scientific discovery video VERBATIM 2026-05-28 — Aaron 'pretty much exactly what we are doing but times 10 almost we are missing a few step' framing + 7 substrate-engineering candidate gaps surfaced (Aaron-forwarded; operator-authorized) Per operator 2026-05-28 explicit authorization: 'ipquestionable folder under docs i authorize'. Video describes 2 Nature papers (same week): - Google co-scientist (multi-agent ecosystem: supervisor / generation / reflection / proximity / evolution / ranking with ELO tournament) - Sakana Robin (closed-loop: Crow + Falcon + Finch with 8-parallel-instance consensus mechanism) Both produce real medical discoveries (cancer/AML drug repurposing Cur 6 + binometanib + JQ1/Olarib/MSA2 combinations; liver fibrosis Vorinostat; AMR CFPICI+phage tails; AMD Y27632 + Reposutal + KL00001 circadian-clock drug). Economics: 400 human-hours → 2 hours AI + $10.76 compute. Aaron's framing decomposes into: - 'this is pretty much exactly what we are doing' — Zeta framework substrate composes with co-scientist + Robin patterns at multiple scopes (12-row table preserved in §33 composition section) - 'but times 10' — Zeta operates at 10× scope (cross-domain + multi-substrate- entity + cross-vendor + cluster + accelerator + workflow + everything else) - 'almost we are missing a few step' — 7 substrate-engineering candidate gaps surfaced: 1. ELO-style ranking-agent + tournament between hypothesis 2. Explicit closed-loop CI-result → next-hypothesis dispatch 3. n-parallel-agent-instances + consensus at per-data-analysis-task scope 4. Generation+reflection adversarial pairing structurally enforced 5. Evolution agent (mash + refine surviving substrate) 6. Proximity-agent for substrate-engineering substrate de-duplication 7. Falcon-style auto-generate-substrate-research-doc per proposal Each gap composes with shipped substrate this session (B-0867.20 + B-0865.17 + B-0883 + B-0891 + 15 ferry preservations). Substrate-engineering candidates surface from framework's already-operational 10× scope; recommended next- substrate-work surfaced (not pre-empting; operator-substrate-direction). Labeling-confidence tiers per PR #5739: - Aaron verbatim framing: canonical (operator-substrate-honest disclosure) - YouTube transcript: canonical-IP-flagged (per ip-questionable folder) - Otto-CLI 7-missing-steps composition: observed Non-fusion disclaimer: 3 distinct authorial substrates preserved alongside without identity-fusion per asymmetric-authorship + honor-those-that-came- before + NCI HC-8. Per ip-questionable/README.md: operator (Rodney Aaron Stainback) has accepted personal liability for verbatim reproduction in this folder per _ip_risk_acceptance settings.json block. Co-Authored-By: Claude Opus 4.7 <noreply@anthropic.com>
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…fer.NET to upstream references + backlog B-0914 7-candidate substrate-engineering gap decomposition (Aaron 2026-05-28 explicit) (#5763) * docs+feat(B-0914 + upstream): add co-scientist + Robin + Microsoft Infer.NET to references/reference-sources.json + UPSTREAM-LIST.md + backlog B-0914 7-candidate substrate-engineering gap decomposition (Aaron 2026-05-28: 'we should add coscientis and add it to our upstram references and refersh update them so we can take a peak lol also lets backlog all the candidates') Per Aaron 2026-05-28 explicit substrate-engineering directives: 1. 'we should add coscientis and add it to our upstram references' → added 6 entries to references/reference-sources.json: - SakanaAI/AI-Scientist (original v1) - SakanaAI/AI-Scientist-v2 (Robin descendant; agentic tree search) - jataware/open-coscientist (best open-source co-scientist via LangGraph) - llnl/open-ai-co-scientist (LLNL government-lab implementation) - The-Swarm-Corporation/AI-CoScientist (minimal Swarms framework) - Microsoft Research Infer.NET (TrueSkill substrate; canonical) 2. 'refresh update them so we can take a peak' → operator may run tools/setup/common/sync-upstreams.sh to mirror new repos into references/upstreams/ (operator-side; not auto-run by Otto-CLI per safety discipline) 3. 'lets backlog all the candidates' → filed B-0914 parent row with 7-candidate decomposition: - B-0914.1 ELO-style ranking-agent via TrueSkill/Infer.NET - B-0914.2 Closed-loop CI-result → next-hypothesis dispatch - B-0914.3 n-parallel-agent-instances + consensus per data-analysis-task - B-0914.4 Generation+reflection adversarial pairing structurally enforced - B-0914.5 Evolution agent (mash + refine surviving substrate) - B-0914.6 Proximity-agent for substrate-engineering substrate de-duplication - B-0914.7 Falcon-style auto-generate-substrate-research-doc per proposal Also added 'Multi-agent scientific discovery' section to docs/UPSTREAM-LIST.md naming Google co-scientist + Sakana Robin + Microsoft Infer.NET TrueSkill with substrate-engineering composition notes. Per WebSearch 2026-05-28 verification: - https://github.com/SakanaAI/AI-Scientist - https://github.com/SakanaAI/AI-Scientist-v2 - https://github.com/jataware/open-coscientist - https://github.com/llnl/open-ai-co-scientist - https://github.com/The-Swarm-Corporation/AI-CoScientist - https://github.com/dotnet/infer - Google co-scientist itself closed-source (Nature 2026; only Science Skills data layer on GitHub) - Sakana Robin: Nature 2026 (s41586-026-10652-y); arXiv:2505.13400 Composes with PR #5762 (YouTube ferry preservation) + B-0867 workflow engine substrate cluster + B-0865 + B-0865.17 benchmark + B-0703 multi-oracle BFT. Co-Authored-By: Claude Opus 4.7 <noreply@anthropic.com> * fix(B-0914): markdownlint MD022/MD032 — add blank lines around list + heading Fixes failing required check `lint (markdownlint)` on PR #5763: - docs/UPSTREAM-LIST.md:150 — blank line above `### Probabilistic programming / Bayesian inference` heading - docs/backlog/P2/B-0914-...md:178 — blank line above `- This PR: adds SakanaAI/AI-Scientist…` list Co-Authored-By: Claude Opus 4.7 <noreply@anthropic.com> --------- Co-authored-by: Lior <lior@zeta.dev> Co-authored-by: Claude Opus 4.7 <noreply@anthropic.com>
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Summary
Preserves YouTube video transcript (https://www.youtube.com/watch?v=QvN6Tu6dHYM) verbatim per operator 2026-05-28 explicit authorization: 'ipquestionable folder under docs i authorize'.
Video covers 2 Nature papers (same week):
Both produce real medical discoveries (AML drug repurposing; liver fibrosis Vorinostat; AMR CFPICI+phage tails; AMD circadian-clock drug). Economics: 400 human-hours → 2 hours AI + $10.76 compute.
Aaron's framing
Substrate-engineering decomposition:
7 substrate-engineering candidate gaps
Each composes with shipped substrate today.
Labeling-confidence tiers
Per
ip-questionable/README.md: operator (Rodney Aaron Stainback) accepts personal liability for verbatim reproduction per_ip_risk_acceptancesettings.json block.Test plan
🤖 Generated with Claude Code