Required Model Features

	Measles/Rubella	Cholera	Polio	Malaria Vector Genetics	Cassava Brown Streak (small scale)	Cassava Brown Streak (large scale)
# Agents	200×106 (i) 700×106 (ii) 109 (iii)	200×106 (i)	200×106 (i)	10×106 vectors 0.5×106 humans	6×103 plants ? vectors	"Node-as-agent" type
# Locations	103 (i) 105 (iii)	103	103	103	# of agents	SSA in 1km cells
Age-based Mixing	☑︎		☑︎
SES Properties	☑︎	?	☑︎
Maternal Antibodies	☑︎
Waning Immunity	TBD (iv)	TBD (v)	☑︎	?
Environmental Reservoirs		☑︎	?
RI	☑︎	?	☑︎
SIAs	☑︎	?	☑︎
Reactive Interventions	☑︎	☑︎	☑︎		☑︎	☑︎
Seasonality	☑︎	?	☑︎	☑︎
Multi-strain			☑︎	c.f. Basic Genetics
Viral Evolution			☑︎
Basic Genetics	?			☑︎
Contagion/Agent Migration (vi)	TBD (vii)	¿contagion?	agent	agent	vector	dispersal kernel
Viral Titer Titer-dependent infectivity/symptomaticity			?		☑︎
Simulated Surveillance	☑︎	☑︎	☑︎		☑︎	☑︎
Notes	Spatial heterogeneity in demography, RI, SIA schedules and performance.		Dose-dependent immunity		Different intervention types than human diseases - cull & replace agents	Node-as-agent: tracking proportion susceptible, infected, removed rather than agents

(i) Nigeria or Pakistan, e.g., current population
(ii) Nigeria or Pakistan, e.g., at end of 50 year simulation
(iii) Sub-Saharan Africa
(iv) open question for measles
(v) required for accurate vaccine modeling?
(vi) fungible contagion would not require agent migration, identifiable contagion, e.g., polio with viral evolution or vector genetics with identifiable genomes does
(vii) measles could require agent migration depending on impact of age-based mixing