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Implementation of cross-calibration and precision analysis for HR-pQCT

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XcalRep

Implementation of cross-calibration and precision analysis for HR-pQCT.

Citation

Mikolajewicz, N., Zimmermann, E. A., Rummler, M., Hosseinitabatabaei, S., Julien, C., Glorieux, F. H., ... & Willie, B. M. (2021). Multisite longitudinal calibration of HR-pQCT scanners and precision in osteogenesis imperfecta. Bone, 147, 115880.

https://pubmed.ncbi.nlm.nih.gov/33561589/

Description

XcalRep (x-calibration & reproducibility) is an R implementation of methods used for cross-calibration and precision analysis of HR-pQCT It enables cross-calibration and precision analysis in R for single- and multi-centre studies, conducted at single or multiple timepoints. XcalRep was developed with intended use for HR-pQCT, however, it easily extends to other instruments which undergo routine calibration and reproducibility assessment.

The XcalRep package provides the following utilities:

  • single and multi-site precision error calculation (CV and SD-based errors)
  • reference site selection
  • scanner cross-calibration

Additionally, the XcalRep package provides multiple visualization tools to evaluate scanner reproducibility.

Visit XcalRep package site for documentation and step-by-step tutorials/vignettes.

Installation

Firstly, please install or update the package devtools by running

install.packages("devtools")

Then the XcalRep can be installed via

library(devtools)
install_github(repo = "NMikolajewicz/XcalRep")

Authors

License

This project is licensed under the MIT License - see the LICENSE.md file for details

Acknowledgments

  • Bettina Willie, Elizabeth Zimmermann

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