diff --git a/crates/uv-install-wheel/src/wheel.rs b/crates/uv-install-wheel/src/wheel.rs
index 6cf90e50636c1..191d7d94efd6b 100644
--- a/crates/uv-install-wheel/src/wheel.rs
+++ b/crates/uv-install-wheel/src/wheel.rs
@@ -201,21 +201,25 @@ impl<'script> ValidatedScript<'script> {
         // Apply the Windows launcher normalization before checking so wheel validity is portable.
         // FIXME: What are the in-reality rules here for name normalization?
         let normalized_name = name.strip_suffix(".py").unwrap_or(name.as_str());
-        if RESERVED_SCRIPT_NAMES_ERROR.contains(&normalized_name)
-            || normalized_name
+        let lowercase_name = name.to_ascii_lowercase();
+        let reserved_name = lowercase_name
+            .strip_suffix(".py")
+            .unwrap_or(&lowercase_name);
+        if RESERVED_SCRIPT_NAMES_ERROR.contains(&reserved_name)
+            || reserved_name
                 .strip_prefix(RESERVED_VERSIONED_SCRIPT_NAME_PREFIX_ERROR)
                 .is_some_and(|minor| minor.parse::<u8>().is_ok())
             || RESERVED_FREE_THREADED_SCRIPT_NAME_PREFIXES_ERROR
                 .iter()
                 .any(|prefix| {
-                    normalized_name
+                    reserved_name
                         .strip_prefix(prefix)
                         .and_then(|minor| minor.strip_suffix('t'))
                         .is_some_and(|minor| minor.parse::<u8>().is_ok())
                 })
         {
             return Err(Error::ReservedScriptName {
-                reserved: normalized_name.to_string(),
+                reserved: reserved_name.to_string(),
                 declared: script.name.clone(),
             });
         }
diff --git a/crates/uv/tests/pip_install/pip_install.rs b/crates/uv/tests/pip_install/pip_install.rs
index 118570ccacec7..e83e8cec08d78 100644
--- a/crates/uv/tests/pip_install/pip_install.rs
+++ b/crates/uv/tests/pip_install/pip_install.rs
@@ -14252,6 +14252,56 @@ fn reject_normalized_reserved_wheel_entrypoint_name() -> Result<()> {
     Ok(())
 }
 
+#[test]
+fn reject_case_variant_reserved_wheel_entrypoint_name() -> Result<()> {
+    let context = uv_test::test_context!("3.12");
+    let repacked_wheel = repacked_wheel_with_entrypoint(&context, "console_scripts", "Python")?;
+
+    uv_snapshot!(context.filters(), context.pip_install().arg(&repacked_wheel), @"
+    success: false
+    exit_code: 2
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 1 package in [TIME]
+    Prepared 1 package in [TIME]
+    error: Failed to install: foo-0.1.0-py3-none-any.whl (foo==0.1.0 (from file://[TEMP_DIR]/foo-0.1.0-py3-none-any.whl))
+      Caused by: Scripts must not use the reserved name `python`, got: `Python`
+    ");
+
+    let context = uv_test::test_context!("3.12");
+    let repacked_wheel = repacked_wheel_with_entrypoint(&context, "console_scripts", "Python.PY")?;
+
+    uv_snapshot!(context.filters(), context.pip_install().arg(&repacked_wheel), @"
+    success: false
+    exit_code: 2
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 1 package in [TIME]
+    Prepared 1 package in [TIME]
+    error: Failed to install: foo-0.1.0-py3-none-any.whl (foo==0.1.0 (from file://[TEMP_DIR]/foo-0.1.0-py3-none-any.whl))
+      Caused by: Scripts must not use the reserved name `python`, got: `Python.PY`
+    ");
+
+    let context = uv_test::test_context!("3.12");
+    let repacked_wheel = repacked_wheel_with_entrypoint(&context, "console_scripts", "python.Py")?;
+
+    uv_snapshot!(context.filters(), context.pip_install().arg(&repacked_wheel), @"
+    success: false
+    exit_code: 2
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 1 package in [TIME]
+    Prepared 1 package in [TIME]
+    error: Failed to install: foo-0.1.0-py3-none-any.whl (foo==0.1.0 (from file://[TEMP_DIR]/foo-0.1.0-py3-none-any.whl))
+      Caused by: Scripts must not use the reserved name `python`, got: `python.Py`
+    ");
+
+    Ok(())
+}
+
 #[test]
 fn reject_normalized_reserved_gui_wheel_entrypoint_name() -> Result<()> {
     let context = uv_test::test_context!("3.12");