diff --git a/modules/core/src/main/java/org/apache/synapse/deployers/LocalEntryDeployer.java b/modules/core/src/main/java/org/apache/synapse/deployers/LocalEntryDeployer.java
index ab6df62101..97539f8094 100644
--- a/modules/core/src/main/java/org/apache/synapse/deployers/LocalEntryDeployer.java
+++ b/modules/core/src/main/java/org/apache/synapse/deployers/LocalEntryDeployer.java
@@ -21,16 +21,34 @@
 
 import org.apache.axiom.om.OMElement;
 import org.apache.axis2.deployment.DeploymentException;
+import org.apache.commons.io.IOUtils;
 import org.apache.commons.logging.Log;
 import org.apache.commons.logging.LogFactory;
+import org.apache.commons.io.FileUtils;
+import org.apache.synapse.SynapseConstants;
 import org.apache.synapse.config.Entry;
 import org.apache.synapse.config.xml.EntryFactory;
 import org.apache.synapse.config.xml.EntrySerializer;
 import org.apache.synapse.config.xml.MultiXMLConfigurationBuilder;
+import org.apache.synapse.transport.dynamicconfigurations.KeyStoreReloaderHolder;
+import org.apache.synapse.transport.nhttp.config.SslSenderTrustStoreHolder;
 
 import java.io.File;
+import java.io.FileInputStream;
+import java.io.FileOutputStream;
+import java.io.IOException;
+import java.io.InputStream;
+import java.security.KeyStore;
+import java.security.KeyStoreException;
+import java.security.NoSuchAlgorithmException;
+import java.security.cert.Certificate;
+import java.security.cert.CertificateException;
+import java.security.cert.CertificateFactory;
+import java.util.Iterator;
 import java.util.Properties;
 
+import javax.xml.namespace.QName;
+
 /**
  *  Handles the <code>LocalEntry</code> deployment and undeployment tasks
  *
@@ -39,6 +57,10 @@
 public class LocalEntryDeployer extends AbstractSynapseArtifactDeployer {
 
     private static Log log = LogFactory.getLog(LocalEntryDeployer.class);
+    private static final String RESOURCES_IDENTIFIER = "resources:";
+    private static final String CONVERTED_RESOURCES_IDENTIFIER = "gov:mi-resources" + File.separator;
+    private static final String HTTP_CONNECTION_IDENTIFIER = "http.init";
+    private static final String CERTIFICATE_EXTENSION = ".crt";
 
     @Override
     public String deploySynapseArtifact(OMElement artifactConfig, String fileName,
@@ -66,6 +88,7 @@ public String deploySynapseArtifact(OMElement artifactConfig, String fileName,
                 }
                 log.info("LocalEntry named '" + e.getKey()
                         + "' has been deployed from file : " + fileName);
+                handleSSLSenderCertificates(artifactConfig);
                 return e.getKey();
             } else {
                 handleSynapseArtifactDeploymentError("LocalEntry Deployment Failed. The artifact " +
@@ -79,6 +102,78 @@ public String deploySynapseArtifact(OMElement artifactConfig, String fileName,
         return null;
     }
 
+    private void handleSSLSenderCertificates(OMElement element) throws DeploymentException {
+
+        OMElement httpInitElement =
+                element.getFirstChildWithName(new QName(SynapseConstants.SYNAPSE_NAMESPACE, HTTP_CONNECTION_IDENTIFIER));
+        if (httpInitElement != null) {
+            Iterator childElementIterator = httpInitElement.getChildElements();
+            while (childElementIterator.hasNext()) {
+                OMElement childElement = (OMElement) childElementIterator.next();
+                String childElementValue = childElement.getText();
+                String transformedElementValue = getTransformedElementValue(childElementValue);
+                if (transformedElementValue.endsWith(CERTIFICATE_EXTENSION)) {
+                    loadCertificateFileToSSLSenderTrustStore(transformedElementValue);
+                    loadUpdatedSSL();
+                }
+            }
+        }
+    }
+
+    private void loadCertificateFileToSSLSenderTrustStore(String certificateFileResourceKey) throws DeploymentException {
+
+        String certificateFilePath = getSynapseConfiguration().getRegistry().getRegistryEntry(certificateFileResourceKey).getName();
+        File certificateFile = new File(certificateFilePath);
+        String certificateAlias = certificateFile.getName().split("\\.")[0];
+        SslSenderTrustStoreHolder sslSenderTrustStoreHolder = SslSenderTrustStoreHolder.getInstance();
+        if (sslSenderTrustStoreHolder.isValid()) {
+            try (FileInputStream certificateFileInputStream = FileUtils.openInputStream(new File(certificateFilePath))) {
+                KeyStore sslSenderTrustStore = sslSenderTrustStoreHolder.getKeyStore();
+
+                CertificateFactory certificateFactory = CertificateFactory.getInstance("X.509");
+                Certificate certificate = certificateFactory.generateCertificate(certificateFileInputStream);
+                sslSenderTrustStore.setCertificateEntry(certificateAlias, certificate);
+
+                try (FileOutputStream fileOutputStream = new FileOutputStream(sslSenderTrustStoreHolder.getLocation())) {
+                    sslSenderTrustStore.store(fileOutputStream, sslSenderTrustStoreHolder.getPassword().toCharArray());
+                }
+            } catch (CertificateException | IOException | KeyStoreException | NoSuchAlgorithmException e) {
+                throw new DeploymentException("Failed to load certificate file to store: " + certificateFilePath, e);
+            }
+        }
+    }
+
+    private void loadUpdatedSSL() throws DeploymentException {
+        SslSenderTrustStoreHolder sslSenderTrustStoreHolder = SslSenderTrustStoreHolder.getInstance();
+        KeyStore sslSenderTrustStore = sslSenderTrustStoreHolder.getKeyStore();
+        if (sslSenderTrustStoreHolder.isValid()) {
+            try (
+                    FileInputStream fileInputStream = new FileInputStream(sslSenderTrustStoreHolder.getLocation());
+                    InputStream bufferedInputStream = IOUtils.toBufferedInputStream(fileInputStream)
+            ) {
+                sslSenderTrustStore.load(bufferedInputStream, sslSenderTrustStoreHolder.getPassword().toCharArray());
+                sslSenderTrustStoreHolder.setKeyStore(sslSenderTrustStore);
+                KeyStoreReloaderHolder.getInstance().reloadAllKeyStores();
+            } catch (IOException | CertificateException | NoSuchAlgorithmException e) {
+                throw new DeploymentException("Failed to load updated SSL configuration from the trust store at: " + sslSenderTrustStoreHolder.getLocation(), e);
+            }
+        }
+    }
+
+    /**
+     * Transforms the given element value if it indicates a resource file.
+     *
+     * @param elementValue the value of the element to be transformed
+     * @return the transformed element value
+     */
+    private String getTransformedElementValue(String elementValue) {
+        String transformedElementValue = elementValue.trim();
+        if (transformedElementValue.startsWith(RESOURCES_IDENTIFIER)) {
+            transformedElementValue = transformedElementValue.replace(RESOURCES_IDENTIFIER, CONVERTED_RESOURCES_IDENTIFIER);
+        }
+        return transformedElementValue;
+    }
+
     @Override
     public String updateSynapseArtifact(OMElement artifactConfig, String fileName,
                                         String existingArtifactName, Properties properties) {
diff --git a/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/dynamicconfigurations/IKeyStoreLoader.java b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/dynamicconfigurations/IKeyStoreLoader.java
new file mode 100644
index 0000000000..11977260ef
--- /dev/null
+++ b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/dynamicconfigurations/IKeyStoreLoader.java
@@ -0,0 +1,26 @@
+/*
+ *  Copyright (c) 2024, WSO2 LLC. (https://www.wso2.com).
+ *
+ *  WSO2 LLC. licenses this file to you under the Apache License,
+ *  Version 2.0 (the "License"); you may not use this file except
+ *  in compliance with the License.
+ *  You may obtain a copy of the License at
+ *
+ *    http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *  Unless required by applicable law or agreed to in writing,
+ *  software distributed under the License is distributed on an
+ *  "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+ *  KIND, either express or implied.  See the License for the
+ *  specific language governing permissions and limitations
+ *  under the License.
+ */
+package org.apache.synapse.transport.dynamicconfigurations;
+
+import org.apache.axis2.AxisFault;
+import org.apache.axis2.description.ParameterInclude;
+
+public interface IKeyStoreLoader {
+
+    void loadKeyStore(ParameterInclude transport) throws AxisFault;
+}
diff --git a/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/dynamicconfigurations/KeyStoreReloader.java b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/dynamicconfigurations/KeyStoreReloader.java
new file mode 100644
index 0000000000..a077b35174
--- /dev/null
+++ b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/dynamicconfigurations/KeyStoreReloader.java
@@ -0,0 +1,45 @@
+/*
+ *  Copyright (c) 2024, WSO2 LLC. (https://www.wso2.com).
+ *
+ *  WSO2 LLC. licenses this file to you under the Apache License,
+ *  Version 2.0 (the "License"); you may not use this file except
+ *  in compliance with the License.
+ *  You may obtain a copy of the License at
+ *
+ *    http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *  Unless required by applicable law or agreed to in writing,
+ *  software distributed under the License is distributed on an
+ *  "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+ *  KIND, either express or implied.  See the License for the
+ *  specific language governing permissions and limitations
+ *  under the License.
+ */
+package org.apache.synapse.transport.dynamicconfigurations;
+
+import org.apache.axis2.AxisFault;
+import org.apache.axis2.description.ParameterInclude;
+
+public class KeyStoreReloader {
+
+    private IKeyStoreLoader keyStoreLoader;
+    private ParameterInclude transportOutDescription;
+
+    public KeyStoreReloader(IKeyStoreLoader keyStoreLoader, ParameterInclude transportOutDescription) {
+
+        this.keyStoreLoader = keyStoreLoader;
+        this.transportOutDescription = transportOutDescription;
+
+        registerListener(transportOutDescription);
+    }
+
+    private void registerListener(ParameterInclude transportOutDescription) {
+
+        KeyStoreReloaderHolder.getInstance().addKeyStoreLoader(this);
+    }
+
+    public void update() throws AxisFault {
+
+        keyStoreLoader.loadKeyStore(transportOutDescription);
+    }
+}
diff --git a/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/dynamicconfigurations/KeyStoreReloaderHolder.java b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/dynamicconfigurations/KeyStoreReloaderHolder.java
new file mode 100644
index 0000000000..dbfbe984e6
--- /dev/null
+++ b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/dynamicconfigurations/KeyStoreReloaderHolder.java
@@ -0,0 +1,47 @@
+/*
+ *  Copyright (c) 2024, WSO2 LLC. (https://www.wso2.com).
+ *
+ *  WSO2 LLC. licenses this file to you under the Apache License,
+ *  Version 2.0 (the "License"); you may not use this file except
+ *  in compliance with the License.
+ *  You may obtain a copy of the License at
+ *
+ *    http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *  Unless required by applicable law or agreed to in writing,
+ *  software distributed under the License is distributed on an
+ *  "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+ *  KIND, either express or implied.  See the License for the
+ *  specific language governing permissions and limitations
+ *  under the License.
+ */
+package org.apache.synapse.transport.dynamicconfigurations;
+
+import org.apache.axis2.AxisFault;
+
+import java.util.ArrayList;
+import java.util.List;
+
+public class KeyStoreReloaderHolder {
+
+    private static KeyStoreReloaderHolder instance = new KeyStoreReloaderHolder();
+    private List<KeyStoreReloader> keyStoreLoaders;
+
+    private KeyStoreReloaderHolder() {
+        keyStoreLoaders = new ArrayList<>();
+    }
+
+    public static KeyStoreReloaderHolder getInstance() {
+        return instance;
+    }
+
+    public void addKeyStoreLoader(KeyStoreReloader keyStoreLoader) {
+        keyStoreLoaders.add(keyStoreLoader);
+    }
+
+    public void reloadAllKeyStores() throws AxisFault {
+        for (KeyStoreReloader keyStoreLoader : keyStoreLoaders) {
+            keyStoreLoader.update();
+        }
+    }
+}
diff --git a/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/nhttp/config/ClientConnFactoryBuilder.java b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/nhttp/config/ClientConnFactoryBuilder.java
index 66fde8487c..d85def1532 100644
--- a/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/nhttp/config/ClientConnFactoryBuilder.java
+++ b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/nhttp/config/ClientConnFactoryBuilder.java
@@ -370,14 +370,18 @@ private SSLContext createSSLContext(OMElement keyStoreElt, OMElement trustStoreE
                 if (log.isDebugEnabled()) {
                     log.debug(name + " Loading Trust Keystore from : " + location);
                 }
-                SslSenderTrustStoreHolder.getInstance().setLocation(location);
-                SslSenderTrustStoreHolder.getInstance().setPassword(passwordElement.getText());
-                SslSenderTrustStoreHolder.getInstance().setType(type);
+
                 trustStore.load(fis, storePassword.toCharArray());
                 TrustManagerFactory trustManagerfactory = TrustManagerFactory.getInstance(
                         TrustManagerFactory.getDefaultAlgorithm());
                 trustManagerfactory.init(trustStore);
                 trustManagers = trustManagerfactory.getTrustManagers();
+
+                SslSenderTrustStoreHolder sslSenderTrustStoreHolder = SslSenderTrustStoreHolder.getInstance();
+                sslSenderTrustStoreHolder.setKeyStore(trustStore);
+                sslSenderTrustStoreHolder.setLocation(location);
+                sslSenderTrustStoreHolder.setPassword(storePassword);
+                SslSenderTrustStoreHolder.getInstance().setType(type);
             } catch (GeneralSecurityException gse) {
                 log.error(name + " Error loading Key store : " + location, gse);
                 throw new AxisFault("Error loading Key store : " + location, gse);
@@ -472,6 +476,11 @@ private SSLContext createSSLContext(OMElement keyStoreElt, OMElement trustStoreE
                 trustManagerfactory.init(trustStore);
                 trustManagers = trustManagerfactory.getTrustManagers();
 
+                SslSenderTrustStoreHolder sslSenderTrustStoreHolder = SslSenderTrustStoreHolder.getInstance();
+                sslSenderTrustStoreHolder.setKeyStore(trustStore);
+                sslSenderTrustStoreHolder.setLocation(location);
+                sslSenderTrustStoreHolder.setPassword(storePassword);
+
             } catch (GeneralSecurityException gse) {
                 log.error(name + " Error loading Key store : " + location, gse);
                 throw new AxisFault("Error loading Key store : " + location, gse);
diff --git a/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/nhttp/config/SslSenderTrustStoreHolder.java b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/nhttp/config/SslSenderTrustStoreHolder.java
index ae1a4dcb6d..5177acbb46 100644
--- a/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/nhttp/config/SslSenderTrustStoreHolder.java
+++ b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/nhttp/config/SslSenderTrustStoreHolder.java
@@ -17,6 +17,8 @@
  */
 package org.apache.synapse.transport.nhttp.config;
 
+import java.security.KeyStore;
+
 /**
  * The SSL Sender TrustStore Holder class to store the client trust store's configurable details.
  */
@@ -26,6 +28,7 @@ public class SslSenderTrustStoreHolder {
 
     private SslSenderTrustStoreHolder() {}
 
+    private KeyStore keyStore;
     private String location;
     private String password;
     private String type;
@@ -33,7 +36,7 @@ private SslSenderTrustStoreHolder() {}
     public static SslSenderTrustStoreHolder getInstance() {
 
         if (instance == null) {
-            synchronized (TrustStoreHolder.class) {
+            synchronized (SslSenderTrustStoreHolder.class) {
                 if (instance == null) {
                     instance = new SslSenderTrustStoreHolder();
                 }
@@ -42,6 +45,21 @@ public static SslSenderTrustStoreHolder getInstance() {
         return instance;
     }
 
+    public static void resetInstance() {
+
+        instance = null;
+    }
+
+    public KeyStore getKeyStore() {
+
+        return keyStore;
+    }
+
+    public void setKeyStore(KeyStore keyStore) {
+
+        this.keyStore = keyStore;
+    }
+
     public void setLocation(String location) {
         this.location = location;
     }
@@ -65,4 +83,9 @@ public void setType(String type) {
     public String getType() {
         return this.type;
     }
+
+    public boolean isValid() {
+        return keyStore != null && location != null && !location.isEmpty() &&
+                password != null && !password.isEmpty();
+    }
 }
diff --git a/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/passthru/PassThroughHttpSSLSender.java b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/passthru/PassThroughHttpSSLSender.java
index 5fe55383d0..f10541807c 100644
--- a/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/passthru/PassThroughHttpSSLSender.java
+++ b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/passthru/PassThroughHttpSSLSender.java
@@ -21,18 +21,21 @@
 import org.apache.axis2.description.ParameterInclude;
 import org.apache.axis2.description.TransportOutDescription;
 import org.apache.synapse.transport.certificatevalidation.cache.CertCache;
+import org.apache.synapse.transport.dynamicconfigurations.IKeyStoreLoader;
+import org.apache.synapse.transport.dynamicconfigurations.KeyStoreReloader;
 import org.apache.synapse.transport.dynamicconfigurations.SSLProfileLoader;
 import org.apache.synapse.transport.dynamicconfigurations.SenderProfileReloader;
 import org.apache.synapse.transport.http.conn.Scheme;
 import org.apache.synapse.transport.nhttp.config.ClientConnFactoryBuilder;
 import org.apache.synapse.transport.nhttp.config.TrustStoreHolder;
 
-public class PassThroughHttpSSLSender extends PassThroughHttpSender implements SSLProfileLoader {
+public class PassThroughHttpSSLSender extends PassThroughHttpSender implements SSLProfileLoader, IKeyStoreLoader {
 
     @Override
     public void init(ConfigurationContext configurationContext,
                      TransportOutDescription transportOutDescription) throws AxisFault {
         super.init(configurationContext, transportOutDescription);
+        new KeyStoreReloader(this, transportOutDescription);
         new SenderProfileReloader(this, transportOutDescription);
     }
 
@@ -60,4 +63,10 @@ public void reloadConfig(ParameterInclude transport) throws AxisFault {
         reloadDynamicSSLConfig((TransportOutDescription) transport);
     }
 
+    @Override
+    public void loadKeyStore(ParameterInclude transport) throws AxisFault {
+        CertCache.resetCache();
+        TrustStoreHolder.resetInstance();
+        reloadSSL((TransportOutDescription) transport);
+    }
 }
diff --git a/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/passthru/PassThroughHttpSender.java b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/passthru/PassThroughHttpSender.java
index 3af961c03f..ccb24756c1 100644
--- a/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/passthru/PassThroughHttpSender.java
+++ b/modules/transports/core/nhttp/src/main/java/org/apache/synapse/transport/passthru/PassThroughHttpSender.java
@@ -722,6 +722,18 @@ public void reloadDynamicSSLConfig(TransportOutDescription transport) throws Axi
         }
     }
 
+    public void reloadSSL(TransportOutDescription transport) throws AxisFault {
+        log.info("PassThroughHttpSender SSL Config..");
+        ClientConnFactoryBuilder connFactoryBuilder =
+                initConnFactoryBuilder(transport, this.configurationContext).parseSSL();
+        connFactory = connFactoryBuilder.createConnFactory(targetConfiguration.getHttpParams());
+
+        handler.setConnFactory(connFactory);
+        ioEventDispatch.setConnFactory(connFactory);
+
+        log.info("Pass-through " + namePrefix + " Sender updated with SSL Configuration Updates ...");
+    }
+
     /**
      * Set content type headers along with the charactor encoding if content type header is not preserved
      * @param msgContext    message context
diff --git a/modules/transports/core/nhttp/src/test/java/org/apache/synapse/transport/nhttp/config/SslSenderTrustStoreHolderTest.java b/modules/transports/core/nhttp/src/test/java/org/apache/synapse/transport/nhttp/config/SslSenderTrustStoreHolderTest.java
new file mode 100644
index 0000000000..4389f5fd17
--- /dev/null
+++ b/modules/transports/core/nhttp/src/test/java/org/apache/synapse/transport/nhttp/config/SslSenderTrustStoreHolderTest.java
@@ -0,0 +1,31 @@
+/*
+ *  Copyright (c) 2024, WSO2 LLC. (https://www.wso2.com).
+ *
+ *  WSO2 LLC. licenses this file to you under the Apache License,
+ *  Version 2.0 (the "License"); you may not use this file except
+ *  in compliance with the License.
+ *  You may obtain a copy of the License at
+ *
+ *    http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *  Unless required by applicable law or agreed to in writing,
+ *  software distributed under the License is distributed on an
+ *  "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+ *  KIND, either express or implied.  See the License for the
+ *  specific language governing permissions and limitations
+ *  under the License.
+ */
+package org.apache.synapse.transport.nhttp.config;
+
+import org.junit.Assert;
+import org.junit.Test;
+
+public class SslSenderTrustStoreHolderTest {
+
+    @Test
+    public void testGetInstance() {
+        SslSenderTrustStoreHolder instance = SslSenderTrustStoreHolder.getInstance();
+        SslSenderTrustStoreHolder instance2 = SslSenderTrustStoreHolder.getInstance();
+        Assert.assertEquals("Instances should be the same.", instance, instance2);
+    }
+}