diff --git a/.changeset/breezy-toys-hear.md b/.changeset/breezy-toys-hear.md
new file mode 100644
index 000000000000..d49d4eede560
--- /dev/null
+++ b/.changeset/breezy-toys-hear.md
@@ -0,0 +1,5 @@
+---
+'astro': patch
+---
+
+Fixes stale scoped styles during HMR when both markup and `<style>` are changed in a single save
diff --git a/packages/astro/src/vite-plugin-astro/hmr.ts b/packages/astro/src/vite-plugin-astro/hmr.ts
index a37937f810da..d3ee53204717 100644
--- a/packages/astro/src/vite-plugin-astro/hmr.ts
+++ b/packages/astro/src/vite-plugin-astro/hmr.ts
@@ -61,6 +61,11 @@ export async function handleHotUpdate(
 			return query.container || (query.astro && query.type === 'style' && !query.inline);
 		});
 	}
+
+	// When non-style content changed (markup, frontmatter, scripts), Vite's default HMR
+	// invalidates the affected modules in its module graph. Clear the compile metadata so
+	// the load hook recompiles from disk on the next request instead of serving stale CSS.
+	astroFileToCompileMetadata.delete(ctx.file);
 }
 
 // Disable eslint as we're not sure how to improve this regex yet
diff --git a/packages/astro/test/units/vite-plugin-astro/hmr.test.ts b/packages/astro/test/units/vite-plugin-astro/hmr.test.ts
index 22e17b6bdf7f..205bc8b15f02 100644
--- a/packages/astro/test/units/vite-plugin-astro/hmr.test.ts
+++ b/packages/astro/test/units/vite-plugin-astro/hmr.test.ts
@@ -1,6 +1,116 @@
 import * as assert from 'node:assert/strict';
 import { describe, it } from 'node:test';
-import { isStyleOnlyChanged } from '../../../dist/vite-plugin-astro/hmr.js';
+import { handleHotUpdate, isStyleOnlyChanged } from '../../../dist/vite-plugin-astro/hmr.js';
+import { defaultLogger } from '../test-utils.ts';
+
+function createHmrTestContext({
+	file,
+	newCode,
+	modules = [],
+}: {
+	file: string;
+	newCode: string;
+	modules?: { id: string }[];
+}) {
+	const ctx = {
+		file,
+		read: () => Promise.resolve(newCode),
+		modules,
+	};
+
+	return ctx;
+}
+
+describe('handleHotUpdate', () => {
+	it('deletes compile metadata when markup and style both change', async () => {
+		const file = '/src/components/Target.astro';
+		const oldCode = '<div>old</div>\n<style>.t { --gen: 0; }</style>';
+		const newCode = '<div>new</div>\n<style>.t { --gen: 1; }</style>';
+
+		const astroFileToCompileMetadata = new Map();
+		astroFileToCompileMetadata.set(file, {
+			originalCode: oldCode,
+			css: [{ code: '.t { --gen: 0; }' }],
+			scripts: [],
+		});
+
+		const ctx = createHmrTestContext({ file, newCode });
+
+		const result = await handleHotUpdate(ctx as any, {
+			logger: defaultLogger,
+			compile: async () => ({}) as any,
+			astroFileToCompileMetadata,
+		});
+
+		// Returns undefined so Vite uses its default full-module invalidation
+		assert.equal(result, undefined);
+		// The stale metadata entry must be deleted so the load hook recompiles from disk
+		assert.equal(astroFileToCompileMetadata.has(file), false);
+	});
+
+	it('keeps metadata and eagerly recompiles when only style changes', async () => {
+		const file = '/src/components/Target.astro';
+		const oldCode = '<div>same</div>\n<style>.t { --gen: 0; }</style>';
+		const newCode = '<div>same</div>\n<style>.t { --gen: 1; }</style>';
+
+		const astroFileToCompileMetadata = new Map();
+		astroFileToCompileMetadata.set(file, {
+			originalCode: oldCode,
+			css: [{ code: '.t { --gen: 0; }' }],
+			scripts: [],
+		});
+
+		const styleModule = { id: file + '?astro&type=style&index=0&lang.css' };
+		const ctx = createHmrTestContext({ file, newCode, modules: [styleModule] });
+		const compile = async (code: string, filename: string) => {
+			astroFileToCompileMetadata.set(filename, {
+				originalCode: code,
+				css: [{ code: '.t { --gen: 1; }' }],
+				scripts: [],
+			});
+			return {};
+		};
+
+		const result = await handleHotUpdate(ctx as any, {
+			logger: defaultLogger,
+			compile: compile as any,
+			astroFileToCompileMetadata,
+		});
+
+		// Returns the style modules for targeted CSS HMR
+		assert.ok(Array.isArray(result));
+		assert.equal(result.length, 1);
+		assert.equal(result[0], styleModule);
+		assert.deepEqual(astroFileToCompileMetadata.get(file), {
+			originalCode: newCode,
+			css: [{ code: '.t { --gen: 1; }' }],
+			scripts: [],
+		});
+	});
+
+	it('deletes compile metadata when only frontmatter changes', async () => {
+		const file = '/src/components/Target.astro';
+		const oldCode = '---\nconst x = 1;\n---\n<div>same</div>\n<style>.t { color: red; }</style>';
+		const newCode = '---\nconst x = 2;\n---\n<div>same</div>\n<style>.t { color: red; }</style>';
+
+		const astroFileToCompileMetadata = new Map();
+		astroFileToCompileMetadata.set(file, {
+			originalCode: oldCode,
+			css: [{ code: '.t { color: red; }' }],
+			scripts: [],
+		});
+
+		const ctx = createHmrTestContext({ file, newCode });
+
+		await handleHotUpdate(ctx as any, {
+			logger: defaultLogger,
+			compile: async () => ({}) as any,
+			astroFileToCompileMetadata,
+		});
+
+		assert.equal(astroFileToCompileMetadata.has(file), false);
+	});
+});
 
 describe('isStyleOnlyChanged', () => {
 	it('should return false if nothing change', () => {