diff --git a/.changeset/stupid-pants-press.md b/.changeset/stupid-pants-press.md
new file mode 100644
index 000000000000..c5807d9923ef
--- /dev/null
+++ b/.changeset/stupid-pants-press.md
@@ -0,0 +1,5 @@
+---
+'astro': patch
+---
+
+Ensure that injected routes from `node_modules` are properly detected
diff --git a/packages/astro/src/@types/astro.ts b/packages/astro/src/@types/astro.ts
index 1c7152fec261..6bcb011bb274 100644
--- a/packages/astro/src/@types/astro.ts
+++ b/packages/astro/src/@types/astro.ts
@@ -1316,16 +1316,20 @@ export interface AstroUserConfig {
  */
 export type InjectedScriptStage = 'before-hydration' | 'head-inline' | 'page' | 'page-ssr';
 
-/**
- * Resolved Astro Config
- * Config with user settings along with all defaults filled in.
- */
-
 export interface InjectedRoute {
 	pattern: string;
 	entryPoint: string;
 	prerender?: boolean;
 }
+
+export interface ResolvedInjectedRoute extends InjectedRoute {
+	resolvedEntryPoint?: URL;
+}
+
+/**
+ * Resolved Astro Config
+ * Config with user settings along with all defaults filled in.
+ */
 export interface AstroConfig extends z.output<typeof AstroConfigSchema> {
 	// Public:
 	// This is a more detailed type than zod validation gives us.
@@ -1414,6 +1418,7 @@ export interface AstroSettings {
 	config: AstroConfig;
 	adapter: AstroAdapter | undefined;
 	injectedRoutes: InjectedRoute[];
+	resolvedInjectedRoutes: ResolvedInjectedRoute[];
 	pageExtensions: string[];
 	contentEntryTypes: ContentEntryType[];
 	dataEntryTypes: DataEntryType[];
diff --git a/packages/astro/src/core/config/settings.ts b/packages/astro/src/core/config/settings.ts
index b15961e5076c..c0274f60293f 100644
--- a/packages/astro/src/core/config/settings.ts
+++ b/packages/astro/src/core/config/settings.ts
@@ -21,6 +21,7 @@ export function createBaseSettings(config: AstroConfig): AstroSettings {
 
 		adapter: undefined,
 		injectedRoutes: [],
+		resolvedInjectedRoutes: [],
 		pageExtensions: ['.astro', '.html', ...SUPPORTED_MARKDOWN_FILE_EXTENSIONS],
 		contentEntryTypes: [markdownContentEntryType],
 		dataEntryTypes: [
diff --git a/packages/astro/src/core/util.ts b/packages/astro/src/core/util.ts
index c3f537243183..ff41a5ed6d6a 100644
--- a/packages/astro/src/core/util.ts
+++ b/packages/astro/src/core/util.ts
@@ -113,8 +113,9 @@ function isInPagesDir(file: URL, config: AstroConfig): boolean {
 }
 
 function isInjectedRoute(file: URL, settings: AstroSettings) {
-	for (const route of settings.injectedRoutes) {
-		if (file.toString().endsWith(route.entryPoint)) return true;
+	let fileURL = file.toString();
+	for (const route of settings.resolvedInjectedRoutes) {
+		if (route.resolvedEntryPoint && fileURL === route.resolvedEntryPoint.toString()) return true;
 	}
 	return false;
 }
diff --git a/packages/astro/src/vite-plugin-integrations-container/index.ts b/packages/astro/src/vite-plugin-integrations-container/index.ts
index 0169a6f71560..54c4d5ee3431 100644
--- a/packages/astro/src/vite-plugin-integrations-container/index.ts
+++ b/packages/astro/src/vite-plugin-integrations-container/index.ts
@@ -1,6 +1,9 @@
 import type { Plugin as VitePlugin } from 'vite';
-import type { AstroSettings } from '../@types/astro.js';
+import type { PluginContext } from 'rollup';
+import type { AstroSettings, InjectedRoute, ResolvedInjectedRoute } from '../@types/astro.js';
 import type { LogOptions } from '../core/logger/core.js';
+
+import { normalizePath } from 'vite';
 import { runHookServerSetup } from '../integrations/index.js';
 
 /** Connect Astro integrations into Vite, as needed. */
@@ -16,5 +19,19 @@ export default function astroIntegrationsContainerPlugin({
 		configureServer(server) {
 			runHookServerSetup({ config: settings.config, server, logging });
 		},
+		async buildStart() {
+			// Ensure the injectedRoutes are all resolved to their final paths through Rollup
+			settings.resolvedInjectedRoutes = await Promise.all(settings.injectedRoutes.map(route => resolveEntryPoint.call(this, route)))
+		},
 	};
 }
+
+async function resolveEntryPoint(this: PluginContext, route: InjectedRoute): Promise<ResolvedInjectedRoute> {
+	const resolvedId = await this.resolve(route.entryPoint)
+		.then(res => res?.id)
+		.catch(() => undefined);
+	if (!resolvedId) return route;
+
+	const resolvedEntryPoint = new URL(`file://${normalizePath(resolvedId)}`);
+	return { ...route, resolvedEntryPoint };
+}