diff --git a/lib/runtime-c-api/build.rs b/lib/runtime-c-api/build.rs
index 7750b00813d..5897001b043 100644
--- a/lib/runtime-c-api/build.rs
+++ b/lib/runtime-c-api/build.rs
@@ -22,7 +22,7 @@ fn main() {
 #endif
 #endif
 
-#if defined(GCC) || defined(__clang__)
+#if defined(GCC) || defined(__GNUC__) || defined(__clang__)
 #if defined(__x86_64__)
 #define ARCH_X86_64
 #endif
diff --git a/lib/runtime-c-api/wasmer.h b/lib/runtime-c-api/wasmer.h
index 836a41df215..40a265cff3b 100644
--- a/lib/runtime-c-api/wasmer.h
+++ b/lib/runtime-c-api/wasmer.h
@@ -8,7 +8,7 @@
 #endif
 #endif
 
-#if defined(GCC) || defined(__clang__)
+#if defined(GCC) || defined(__GNUC__) || defined(__clang__)
 #if defined(__x86_64__)
 #define ARCH_X86_64
 #endif
diff --git a/lib/runtime-c-api/wasmer.hh b/lib/runtime-c-api/wasmer.hh
index 79c350d6080..b437edd4be0 100644
--- a/lib/runtime-c-api/wasmer.hh
+++ b/lib/runtime-c-api/wasmer.hh
@@ -8,7 +8,7 @@
 #endif
 #endif
 
-#if defined(GCC) || defined(__clang__)
+#if defined(GCC) || defined(__GNUC__) || defined(__clang__)
 #if defined(__x86_64__)
 #define ARCH_X86_64
 #endif