diff --git a/tests/models/qwen4_exp/test_ple.py b/tests/models/qwen4_exp/test_ple.py
index 35c24176f8e5..d7747ebfbdb5 100644
--- a/tests/models/qwen4_exp/test_ple.py
+++ b/tests/models/qwen4_exp/test_ple.py
@@ -14,6 +14,9 @@
 import vllm.model_executor.layers.vocab_parallel_embedding as embedding_module
 import vllm.model_executor.parameter as parameter_module
 from vllm.model_executor.layers.quantization.fp8 import Fp8Config
+from vllm.model_executor.layers.quantization.modelopt import (
+    ModelOptMixedPrecisionConfig,
+)
 from vllm.models.qwen4_exp.common.ple import (
     PLEShardOverlap,
     compute_ple_shard_overlap,
@@ -288,6 +291,37 @@ def test_ple_fp8_embedding_respects_checkpoint_shard_exclusions() -> None:
     assert _get_ple_embedding_quant_method(quant_config, prefix) is None
 
 
+def test_ple_fp8_embedding_supports_mixed_precision_config() -> None:
+    prefix = "model.language_model.layers.1.ple.ple_embedding.ngram_embedding"
+    quant_config = ModelOptMixedPrecisionConfig.from_config(
+        {
+            "quantization": {
+                "quant_algo": "MIXED_PRECISION",
+                "exclude_modules": [],
+                "group_size": 16,
+                "quantized_layers": {
+                    prefix: {"quant_algo": "FP8"},
+                    "model.language_model.layers.2.moe.gate_proj": {
+                        "quant_algo": "NVFP4"
+                    },
+                },
+            }
+        }
+    )
+
+    assert isinstance(
+        _get_ple_embedding_quant_method(quant_config, prefix),
+        Qwen4ExpPLEFp8EmbeddingMethod,
+    )
+    assert (
+        _get_ple_embedding_quant_method(
+            quant_config,
+            "model.language_model.layers.2.moe.gate_proj",
+        )
+        is None
+    )
+
+
 def test_dilated_ple_spec_state_rolls_back_before_next_forward() -> None:
     conv_state_len = 6
     dilation = 2
diff --git a/vllm/models/qwen4_exp/nvidia/ple_layer.py b/vllm/models/qwen4_exp/nvidia/ple_layer.py
index c0d909e1c384..9d7091d7a2b3 100644
--- a/vllm/models/qwen4_exp/nvidia/ple_layer.py
+++ b/vllm/models/qwen4_exp/nvidia/ple_layer.py
@@ -22,6 +22,9 @@
     QuantizeMethodBase,
 )
 from vllm.model_executor.layers.quantization.fp8 import Fp8Config
+from vllm.model_executor.layers.quantization.modelopt import (
+    ModelOptMixedPrecisionConfig,
+)
 from vllm.model_executor.layers.quantization.utils.fp8_utils import (
     create_fp8_scale_parameter,
     create_fp8_weight_parameter,
@@ -133,6 +136,11 @@ def _get_ple_embedding_quant_method(
 ) -> QuantizeMethodBase | None:
     """Select global-scale FP8 only for quantized PLE checkpoint shards."""
 
+    if isinstance(quant_config, ModelOptMixedPrecisionConfig):
+        if quant_config._resolve_quant_algo(prefix) == "FP8":
+            return Qwen4ExpPLEFp8EmbeddingMethod()
+        return None
+
     if not isinstance(quant_config, Fp8Config):
         return None
     if not quant_config.is_checkpoint_fp8_serialized: