diff --git a/tests/v1/core/test_kv_cache_utils.py b/tests/v1/core/test_kv_cache_utils.py
index 985b97c69ca4..d1e45e7dae55 100644
--- a/tests/v1/core/test_kv_cache_utils.py
+++ b/tests/v1/core/test_kv_cache_utils.py
@@ -2,6 +2,7 @@
 # SPDX-FileCopyrightText: Copyright contributors to the vLLM project
 import hashlib
 import importlib
+import math
 from collections.abc import Callable
 from typing import Any
 
@@ -44,6 +45,7 @@
     KVCacheGroupSpec,
     KVCacheSpec,
     KVCacheTensor,
+    KVQuantMode,
     MambaSpec,
     MLAAttentionSpec,
     SlidingWindowSpec,
@@ -2189,6 +2191,44 @@ def test_unify_hybrid_kv_cache_specs():
         kv_cache_utils.unify_hybrid_kv_cache_specs(kv_cache_spec)
 
 
+def test_unify_kv_cache_spec_page_size_uses_common_multiple_for_int8_hybrid():
+    kv_cache_spec = {
+        "full": FullAttentionSpec(
+            block_size=16,
+            num_kv_heads=2,
+            head_size=512,
+            head_size_v=512,
+            dtype=torch.float16,
+            kv_quant_mode=KVQuantMode.INT8_PER_TOKEN_HEAD,
+        ),
+        "sliding": SlidingWindowSpec(
+            block_size=16,
+            num_kv_heads=8,
+            head_size=256,
+            dtype=torch.float16,
+            kv_quant_mode=KVQuantMode.INT8_PER_TOKEN_HEAD,
+            sliding_window=1024,
+        ),
+    }
+
+    original_page_sizes = {
+        name: spec.page_size_bytes for name, spec in kv_cache_spec.items()
+    }
+    unified = kv_cache_utils.unify_kv_cache_spec_page_size(kv_cache_spec)
+    expected_page_size = math.lcm(*original_page_sizes.values())
+
+    assert unified["full"].page_size_bytes == unified["sliding"].page_size_bytes
+    assert unified["full"].page_size_bytes == expected_page_size
+    assert unified["full"].block_size == (
+        16 * expected_page_size // original_page_sizes["full"]
+    )
+    assert unified["sliding"].block_size == (
+        16 * expected_page_size // original_page_sizes["sliding"]
+    )
+    assert isinstance(unified["sliding"], SlidingWindowSpec)
+    assert unified["sliding"].sliding_window == 1024
+
+
 def test_hma_not_disabled_when_kv_events_enabled():
     """
     Test enabling KV events must not force disable_hybrid_kv_cache_manager to True.
diff --git a/vllm/v1/core/kv_cache_utils.py b/vllm/v1/core/kv_cache_utils.py
index b57e10b67faa..68475cec47e8 100644
--- a/vllm/v1/core/kv_cache_utils.py
+++ b/vllm/v1/core/kv_cache_utils.py
@@ -8,7 +8,7 @@
 import os
 from collections import defaultdict
 from collections.abc import Callable, Iterable, Iterator, Sequence
-from dataclasses import dataclass, replace
+from dataclasses import dataclass
 from functools import partial
 from typing import Any, NewType, TypeAlias, cast, overload
 
@@ -1024,22 +1024,28 @@ def unify_kv_cache_spec_page_size(
         # All layers have the same page size, no need to unify.
         return kv_cache_spec
 
-    max_page_size = max(page_sizes)
+    unified_page_size = max(page_sizes)
+    if any(unified_page_size % page_size != 0 for page_size in page_sizes):
+        unified_page_size = math.lcm(*page_sizes)
+
     new_kv_cache_spec = {}
     for layer_name, layer_spec in kv_cache_spec.items():
-        if layer_spec.page_size_bytes == max_page_size:
+        if layer_spec.page_size_bytes == unified_page_size:
             new_kv_cache_spec[layer_name] = layer_spec
         else:
             layer_page_size = layer_spec.page_size_bytes
-            if max_page_size % layer_page_size != 0:
+            if unified_page_size % layer_page_size != 0:
                 raise NotImplementedError(
                     "The page size of the layer is not divisible by the "
-                    "maximum page size. Cannot unify by adjusting block_size."
+                    "unified page size. Cannot unify by adjusting block_size."
                 )
-            ratio = max_page_size // layer_page_size
+            ratio = unified_page_size // layer_page_size
             new_block_size = layer_spec.block_size * ratio
-            new_spec = replace(layer_spec, block_size=new_block_size)
-            assert new_spec.page_size_bytes == max_page_size
+            new_spec = layer_spec.copy_with_new_block_size(new_block_size)
+            if new_spec.page_size_bytes != unified_page_size:
+                raise NotImplementedError(
+                    "Failed to unify KV cache page size after adjusting block_size."
+                )
             new_kv_cache_spec[layer_name] = new_spec
     return new_kv_cache_spec
 
@@ -1398,6 +1404,7 @@ def unify_hybrid_kv_cache_specs(kv_cache_spec: dict[str, KVCacheSpec]):
                     num_kv_heads=spec.num_kv_heads,
                     head_size=spec.head_size,
                     dtype=spec.dtype,
+                    kv_quant_mode=spec.kv_quant_mode,
                     attention_chunk_size=spec.attention_chunk_size,
                     page_size_padded=spec.page_size_padded,
                 )
diff --git a/vllm/v1/engine/core.py b/vllm/v1/engine/core.py
index 11c5ee19a664..491dfbea610e 100644
--- a/vllm/v1/engine/core.py
+++ b/vllm/v1/engine/core.py
@@ -11,9 +11,10 @@
 from concurrent.futures import Future
 from contextlib import ExitStack, contextmanager
 from enum import IntEnum
-from functools import partial
+from functools import partial, reduce
 from inspect import isclass, signature
 from logging import DEBUG
+from math import gcd
 from multiprocessing.queues import Queue
 from typing import Any, TypeVar, cast
 
@@ -273,8 +274,9 @@ def _initialize_kv_caches(self, vllm_config: VllmConfig) -> KVCacheConfig:
         vllm_config.cache_config.num_gpu_blocks = scheduler_kv_cache_config.num_blocks
         kv_cache_groups = scheduler_kv_cache_config.kv_cache_groups
         if kv_cache_groups:
-            vllm_config.cache_config.block_size = min(
-                g.kv_cache_spec.block_size for g in kv_cache_groups
+            vllm_config.cache_config.block_size = reduce(
+                gcd,
+                (group.kv_cache_spec.block_size for group in kv_cache_groups),
             )
 
         vllm_config.validate_block_size()