diff --git a/vllm/lora/model_manager.py b/vllm/lora/model_manager.py
index 7611d2d71a03..6cf846cae947 100644
--- a/vllm/lora/model_manager.py
+++ b/vllm/lora/model_manager.py
@@ -249,6 +249,7 @@ def activate_adapter(
             "Activating LoRA. int id: %d, slot index: %d", lora_model.id, index
         )
         self.lora_index_to_id[index] = lora_model.id
+        num_applied = 0
         for module_name, module in self.modules.items():
             module_lora = self._get_lora_layer_weights(lora_model, module_name)
             if not module_lora:
@@ -260,6 +261,16 @@ def activate_adapter(
                 module_lora.lora_a,
                 module_lora.lora_b,
             )
+            num_applied += 1
+
+        if num_applied == 0 and self.modules:
+            logger.warning(
+                "LoRA adapter %d was activated but none of its weights "
+                "matched any LoRA-eligible module. The adapter will have "
+                "no effect. This usually means the model class is missing "
+                "an hf_to_vllm_mapper attribute.",
+                lora_model.id,
+            )
 
         return True
 
diff --git a/vllm/lora/worker_manager.py b/vllm/lora/worker_manager.py
index 2db747e2ceab..160baf9db4db 100644
--- a/vllm/lora/worker_manager.py
+++ b/vllm/lora/worker_manager.py
@@ -130,6 +130,24 @@ def _load_adapter(self, lora_request: LoRARequest) -> LoRAModel:
                 skip_prefixes=lora_skip_prefixes,
             )
 
+            # Check that at least some loaded LoRA modules will match
+            # the model's module names.  When hf_to_vllm_mapper is
+            # missing, LoRA weights may load successfully but with
+            # wrong module paths, causing them to be silently ignored.
+            model_module_names = {name for name, _ in model.named_modules()}
+            matched = any(
+                module_name in model_module_names for module_name in lora.loras
+            )
+            if lora.loras and not matched:
+                logger.warning(
+                    "None of the LoRA modules in adapter '%s' matched "
+                    "any module in %s. The adapter weights will have no "
+                    "effect. This is usually caused by a missing "
+                    "hf_to_vllm_mapper on the model class.",
+                    lora_request.lora_name,
+                    model.__class__.__name__,
+                )
+
         except FileNotFoundError as e:
             # FileNotFoundError should be raised if both
             # - No adapter found to download from huggingface (or in
diff --git a/vllm/model_executor/models/pixtral.py b/vllm/model_executor/models/pixtral.py
index 0cfa8b6a3a84..bef16f68f769 100644
--- a/vllm/model_executor/models/pixtral.py
+++ b/vllm/model_executor/models/pixtral.py
@@ -40,6 +40,7 @@
 )
 from vllm.model_executor.layers.quantization import QuantizationConfig
 from vllm.model_executor.model_loader.weight_utils import default_weight_loader
+from vllm.model_executor.models.utils import WeightsMapper
 from vllm.multimodal import MULTIMODAL_REGISTRY, MultiModalKwargsItems
 from vllm.multimodal.inputs import (
     MultiModalDataDict,
@@ -372,6 +373,15 @@ def _cached_apply_hf_processor(
 class PixtralForConditionalGeneration(
     nn.Module, SupportsLoRA, SupportsMultiModal, SupportsPP
 ):
+    hf_to_vllm_mapper = WeightsMapper(
+        orig_to_new_prefix={
+            "model.language_model.": "language_model.model.",
+            "model.vision_tower.": "vision_tower.",
+            "model.multi_modal_projector.": "multi_modal_projector.",
+            "lm_head.": "language_model.lm_head.",
+        }
+    )
+
     @classmethod
     def get_placeholder_str(cls, modality: str, i: int) -> str | None:
         if modality.startswith("image"):