diff --git a/setup.py b/setup.py
index eb313b7d219c..73c94f1a5b86 100644
--- a/setup.py
+++ b/setup.py
@@ -35,6 +35,8 @@ def load_module_from_path(module_name, path):
 # cannot import envs directly because it depends on vllm,
 #  which is not installed yet
 envs = load_module_from_path('envs', os.path.join(ROOT_DIR, 'vllm', 'envs.py'))
+version = load_module_from_path('version',
+                                os.path.join(ROOT_DIR, 'vllm', 'version.py'))
 
 VLLM_TARGET_DEVICE = envs.VLLM_TARGET_DEVICE
 
@@ -664,7 +666,7 @@ def _read_requirements(filename: str) -> list[str]:
                   "mistral_common[audio]"],  # Required for audio processing
         "video": [],  # Kept for backwards compatibility
         # FlashInfer should be updated together with the Dockerfile
-        "flashinfer": ["flashinfer-python==0.3.0"],
+        "flashinfer": [f"flashinfer-python=={version.FLASHINFER_VERSION}"],
         # Optional deps for AMD FP4 quantization support
         "petit-kernel": ["petit-kernel"],
     },
diff --git a/vllm/utils/flashinfer.py b/vllm/utils/flashinfer.py
index fab134733d4f..6ae0481b1d68 100644
--- a/vllm/utils/flashinfer.py
+++ b/vllm/utils/flashinfer.py
@@ -15,10 +15,12 @@
 
 import requests
 import torch
+from packaging.version import parse
 
 import vllm.envs as envs
 from vllm.logger import init_logger
 from vllm.platforms import current_platform
+from vllm.version import FLASHINFER_VERSION
 
 logger = init_logger(__name__)
 
@@ -39,6 +41,22 @@ def has_flashinfer() -> bool:
     return importlib.util.find_spec("flashinfer") is not None
 
 
+def valid_flashinfer_version() -> bool:
+    """Check the installed FlashInfer version matches the expected."""
+    if not has_flashinfer():
+        return False
+
+    try:
+        import flashinfer
+
+        # Parse both versions to handle version comparison properly
+        expected = parse(FLASHINFER_VERSION)
+        actual = parse(flashinfer.__version__)
+        return actual == expected
+    except (ImportError, AttributeError):
+        return False
+
+
 def _missing(*_: Any, **__: Any) -> NoReturn:
     """Placeholder for unavailable FlashInfer backend."""
     raise RuntimeError(
@@ -65,6 +83,11 @@ def _lazy_import_wrapper(module_name: str,
     def _get_impl():
         if not has_flashinfer():
             return None
+        if not valid_flashinfer_version():
+            raise RuntimeError(
+                "Installed FlashInfer version is not supported. "
+                f"Please install flashinfer-python=={FLASHINFER_VERSION} "
+                "or use the vLLM extra: pip install 'vllm[flashinfer]'")
         mod = _get_submodule(module_name)
         return getattr(mod, attr_name, None) if mod else None
 
@@ -355,6 +378,7 @@ def flashinfer_scaled_fp8_mm(
 
 __all__ = [
     "has_flashinfer",
+    "valid_flashinfer_version",
     "flashinfer_trtllm_fp8_block_scale_moe",
     "flashinfer_cutlass_fused_moe",
     "fp4_quantize",
diff --git a/vllm/version.py b/vllm/version.py
index 6c88b1b5a3bf..9aa4868f28d7 100644
--- a/vllm/version.py
+++ b/vllm/version.py
@@ -39,3 +39,10 @@ def _prev_minor_version():
     # In dev tree, this will return "0.-1", but that will work fine"
     assert isinstance(__version_tuple__[1], int)
     return f"{__version_tuple__[0]}.{__version_tuple__[1] - 1}"
+
+
+# Optional dependency versions
+# This should be kept in sync with:
+# - setup.py extras_require
+# - docker/Dockerfile version specifications
+FLASHINFER_VERSION = "0.3.0"