diff --git a/docs/contributing/profiling.md b/docs/contributing/profiling.md
index 7a2e64f1312..39cd27f5dcf 100644
--- a/docs/contributing/profiling.md
+++ b/docs/contributing/profiling.md
@@ -201,7 +201,81 @@ Trace files are written to the `torch_profiler_dir` specified in your stage YAML
 
 > **Important:** Always stop the same stages you started. Stopping a stage that was never started will produce errors.
 
-### 5. Analyzing Traces
+### 5. Nsight Systems (nsys) Profiling
+
+vLLM-Omni supports NVIDIA Nsight Systems profiling via the `cuda` profiler backend. This uses `torch.cuda.profiler` to mark profiling ranges that nsys captures, and `torch.cuda.nvtx` for annotating trace regions.
+
+#### Configuration
+
+Set `profiler: cuda` in your profiler config. Unlike the `torch` profiler, no `torch_profiler_dir` is needed since nsys manages its own output files.
+
+**Stage YAML (for omni or diffusion stages):**
+```yaml
+stage_args:
+  - stage_id: 0
+    stage_type: llm
+    engine_args:
+      profiler_config:
+        profiler: cuda
+```
+
+**Diffusion CLI:**
+```bash
+python image_to_video.py \
+    --model Wan-AI/Wan2.2-I2V-A14B-Diffusers \
+    --profiler-config '{"profiler": "cuda"}' \
+    ...
+```
+
+#### Running with nsys
+
+Wrap your command with `nsys profile` using `--capture-range=cudaProfilerApi` so nsys only captures the region between `start_profile()` and `stop_profile()`:
+
+```bash
+nsys profile \
+  --capture-range=cudaProfilerApi \
+  --capture-range-end=repeat \
+  --trace-fork-before-exec=true \
+  --cuda-graph-trace=node \
+  -o my_trace \
+  python your_script.py ...
+```
+
+| Flag | Purpose |
+|---|---|
+| `--capture-range=cudaProfilerApi` | Only capture between CUDA profiler start/stop calls |
+| `--capture-range-end=repeat` | Allow multiple start/stop cycles |
+| `--trace-fork-before-exec=true` | Trace child processes (needed for multi-worker) |
+| `--cuda-graph-trace=node` | Trace individual kernels inside CUDA graphs |
+
+#### Online Serving with nsys
+
+1. Start the server under nsys with `profiler: cuda` in your stage YAML:
+```bash
+nsys profile \
+  --capture-range=cudaProfilerApi \
+  --capture-range-end=repeat \
+  --trace-fork-before-exec=true \
+  --cuda-graph-trace=node \
+  -o serving_trace \
+  vllm serve Qwen/Qwen2.5-Omni-7B \
+    --omni \
+    --stage-configs-path qwen2_5_omni.yaml \
+    --port 8091
+```
+
+2. Trigger profiling via HTTP endpoints:
+```bash
+curl -X POST http://localhost:8091/start_profile
+# ... send inference requests ...
+curl -X POST http://localhost:8091/stop_profile
+```
+
+#### Analyzing nsys Traces
+
+Open the `.nsys-rep` output file in NVIDIA Nsight Systems GUI for detailed kernel-level analysis, memory transfers, and NVTX annotations.
+
+### 6. Analyzing Traces
 
 Output files are saved to the `torch_profiler_dir` specified in your stage YAML config.
 
diff --git a/tests/diffusion/test_diffusion_worker_cuda_profiler.py b/tests/diffusion/test_diffusion_worker_cuda_profiler.py
new file mode 100644
index 00000000000..c51f95f9c90
--- /dev/null
+++ b/tests/diffusion/test_diffusion_worker_cuda_profiler.py
@@ -0,0 +1,119 @@
+# SPDX-License-Identifier: Apache-2.0
+# SPDX-FileCopyrightText: Copyright contributors to the vLLM project
+
+"""
+Unit tests for DiffusionWorker CUDA (nsys) profiler integration.
+
+Verifies that DiffusionWorker correctly creates a CudaProfilerWrapper
+when profiler_config.profiler == "cuda", enabling Nsight Systems profiling.
+"""
+
+from unittest.mock import MagicMock, patch
+
+import pytest
+
+pytestmark = [pytest.mark.core_model, pytest.mark.diffusion, pytest.mark.cpu]
+
+
+@pytest.fixture
+def mock_od_config():
+    """Create a mock OmniDiffusionConfig with cuda profiler."""
+    config = MagicMock()
+    config.num_gpus = 1
+    config.master_port = 12345
+    config.enable_sleep_mode = False
+    config.cache_backend = None
+    config.cache_config = None
+    config.model = "test-model"
+    config.diffusion_load_format = "default"
+    config.max_cpu_loras = 0
+    config.lora_path = None
+    config.lora_scale = 1.0
+
+    # Profiler config for cuda (nsys)
+    profiler_config = MagicMock()
+    profiler_config.profiler = "cuda"
+    profiler_config.delay_iterations = 0
+    profiler_config.max_iterations = 0
+    config.profiler_config = profiler_config
+
+    # Parallel config
+    parallel_config = MagicMock()
+    parallel_config.tensor_parallel_size = 1
+    parallel_config.data_parallel_size = 1
+    parallel_config.enable_expert_parallel = False
+    config.parallel_config = parallel_config
+
+    return config
+
+
+class TestDiffusionWorkerCudaProfiler:
+    """Test that DiffusionWorker creates CudaProfilerWrapper for nsys."""
+
+    def test_cuda_profiler_created(self, mock_od_config):
+        """DiffusionWorker should create CudaProfilerWrapper when profiler == 'cuda'."""
+        from vllm_omni.diffusion.worker.diffusion_worker import DiffusionWorker
+
+        with (
+            patch.object(DiffusionWorker, "init_device"),
+            patch.object(DiffusionWorker, "load_model"),
+            patch.object(DiffusionWorker, "init_lora_manager"),
+        ):
+            worker = DiffusionWorker(local_rank=0, rank=0, od_config=mock_od_config, skip_load_model=True)
+
+        from vllm.profiler.wrapper import CudaProfilerWrapper
+
+        assert worker.profiler is not None
+        assert isinstance(worker.profiler, CudaProfilerWrapper)
+
+    def test_torch_profiler_not_created_for_cuda(self, mock_od_config):
+        """CudaProfilerWrapper should not be an OmniTorchProfilerWrapper."""
+        from vllm_omni.diffusion.worker.diffusion_worker import DiffusionWorker
+
+        with (
+            patch.object(DiffusionWorker, "init_device"),
+            patch.object(DiffusionWorker, "load_model"),
+            patch.object(DiffusionWorker, "init_lora_manager"),
+        ):
+            worker = DiffusionWorker(local_rank=0, rank=0, od_config=mock_od_config, skip_load_model=True)
+
+        from vllm_omni.profiler import OmniTorchProfilerWrapper
+
+        assert not isinstance(worker.profiler, OmniTorchProfilerWrapper)
+
+    def test_no_profiler_when_none(self, mock_od_config):
+        """DiffusionWorker should have no profiler when profiler_config is None."""
+        mock_od_config.profiler_config = None
+
+        from vllm_omni.diffusion.worker.diffusion_worker import DiffusionWorker
+
+        with (
+            patch.object(DiffusionWorker, "init_device"),
+            patch.object(DiffusionWorker, "load_model"),
+            patch.object(DiffusionWorker, "init_lora_manager"),
+        ):
+            worker = DiffusionWorker(local_rank=0, rank=0, od_config=mock_od_config, skip_load_model=True)
+
+        assert worker.profiler is None
+
+    def test_profile_start_stop_with_cuda_profiler(self, mock_od_config):
+        """profile() should call start/stop on CudaProfilerWrapper without errors."""
+        from vllm_omni.diffusion.worker.diffusion_worker import DiffusionWorker
+
+        with (
+            patch.object(DiffusionWorker, "init_device"),
+            patch.object(DiffusionWorker, "load_model"),
+            patch.object(DiffusionWorker, "init_lora_manager"),
+        ):
+            worker = DiffusionWorker(local_rank=0, rank=0, od_config=mock_od_config, skip_load_model=True)
+
+        # Mock the underlying cuda profiler methods to avoid actual CUDA calls
+        worker.profiler._cuda_profiler = MagicMock()
+
+        # Should not raise
+        worker.profile(is_start=True)
+        worker.profile(is_start=False)
+
+        # Verify start and stop were called
+        worker.profiler._cuda_profiler.start.assert_called_once()
+        worker.profiler._cuda_profiler.stop.assert_called_once()
diff --git a/vllm_omni/diffusion/worker/diffusion_worker.py b/vllm_omni/diffusion/worker/diffusion_worker.py
index 6e1cabba0ce..6c616298eba 100644
--- a/vllm_omni/diffusion/worker/diffusion_worker.py
+++ b/vllm_omni/diffusion/worker/diffusion_worker.py
@@ -20,6 +20,7 @@
 from vllm.config import CompilationConfig, VllmConfig, set_current_vllm_config
 from vllm.distributed.device_communicators.shm_broadcast import MessageQueue
 from vllm.logger import init_logger
+from vllm.profiler.wrapper import WorkerProfiler
 from vllm.utils.import_utils import resolve_obj_by_qualname
 from vllm.utils.mem_utils import GiB_bytes
 from vllm.v1.worker.workspace import init_workspace_manager
@@ -42,7 +43,7 @@
 from vllm_omni.diffusion.worker.utils import RunnerOutput
 from vllm_omni.lora.request import LoRARequest
 from vllm_omni.platforms import current_omni_platform
-from vllm_omni.profiler import OmniTorchProfilerWrapper, create_omni_profiler
+from vllm_omni.profiler import create_omni_profiler
 from vllm_omni.worker.gpu_memory_utils import get_process_gpu_memory
 
 logger = init_logger(__name__)
@@ -84,7 +85,7 @@ def __init__(
             device=self.device,
         )
         # Initialize profiler if configured
-        self.profiler: OmniTorchProfilerWrapper | None = None
+        self.profiler: WorkerProfiler | None = None
         profiler_config = self.od_config.profiler_config
         if profiler_config and profiler_config.profiler == "torch":
             self.profiler = create_omni_profiler(
@@ -92,6 +93,10 @@ def __init__(
                 worker_name=f"diffusion_worker_{self.rank}",
                 local_rank=self.local_rank,
             )
+        elif profiler_config and profiler_config.profiler == "cuda":
+            from vllm.profiler.wrapper import CudaProfilerWrapper
+
+            self.profiler = CudaProfilerWrapper(profiler_config)
         if not skip_load_model:
             self.load_model(load_format=self.od_config.diffusion_load_format)
             self.init_lora_manager()