diff --git a/.buildkite/nightly-release-pipeline.yaml b/.buildkite/nightly-release-pipeline.yaml
new file mode 100644
index 00000000000..25c52ba3b45
--- /dev/null
+++ b/.buildkite/nightly-release-pipeline.yaml
@@ -0,0 +1,20 @@
+steps:
+  - label: "Build and upload wheel"
+    key: "build-wheel"
+    agents:
+      queue: cpu_queue_release
+    commands:
+      - "curl -LsSf https://astral.sh/uv/install.sh | sh"
+      - 'export PATH="$HOME/.local/bin:$PATH"'
+      - "uv venv --python=3.12 && source .venv/bin/activate"
+      - "uv pip install --upgrade build"
+      - "python3 -m build"
+      - "bash .buildkite/scripts/upload-nightly-wheels.sh"
+
+  - label: "Generate and upload wheel indices"
+    depends_on: "build-wheel"
+    allow_dependency_failure: true
+    agents:
+      queue: small_cpu_queue_release
+    commands:
+      - "bash .buildkite/scripts/generate-and-upload-nightly-index.sh"
diff --git a/.buildkite/scripts/generate-and-upload-nightly-index.sh b/.buildkite/scripts/generate-and-upload-nightly-index.sh
new file mode 100755
index 00000000000..6624af32303
--- /dev/null
+++ b/.buildkite/scripts/generate-and-upload-nightly-index.sh
@@ -0,0 +1,87 @@
+#!/usr/bin/env bash
+
+set -ex
+
+# Generate and upload wheel indices for all vllm-omni wheels in the commit directory.
+# This script should run once after all wheels have been built and uploaded.
+# All paths are under the omni/ prefix in the vllm-wheels S3 bucket.
+
+# ======== setup ========
+
+BUCKET="vllm-wheels"
+INDICES_OUTPUT_DIR="indices"
+PYTHON="${PYTHON_PROG:-python3}"
+SUBPATH="omni/$BUILDKITE_COMMIT"
+S3_COMMIT_PREFIX="s3://$BUCKET/$SUBPATH/"
+
+# detect if python3.12+ is available
+has_new_python=$($PYTHON -c "print(1 if __import__('sys').version_info >= (3,12) else 0)")
+if [[ "$has_new_python" -eq 0 ]]; then
+    # use new python from docker
+    docker pull python:3-slim
+    PYTHON="docker run --rm -v $(pwd):/app -w /app python:3-slim python3"
+fi
+
+echo "Using python interpreter: $PYTHON"
+echo "Python version: $($PYTHON --version)"
+
+# ======== generate and upload indices ========
+
+# list all wheels in the commit directory
+echo "Existing wheels on S3:"
+aws s3 ls "$S3_COMMIT_PREFIX" || echo "(no objects found)"
+obj_json="objects.json"
+aws s3api list-objects-v2 --bucket "$BUCKET" --prefix "$SUBPATH/" --delimiter / --output json > "$obj_json"
+mkdir -p "$INDICES_OUTPUT_DIR"
+
+# HACK: we do not need regex module here, but it is required by pre-commit hook
+# To avoid any external dependency, we simply replace it back to the stdlib re module
+sed -i 's/import regex as re/import re/g' .buildkite/scripts/generate-nightly-index.py
+
+# Generate indices -- the version is just the commit hash (not omni/{commit})
+# because relative paths are computed between the index and wheel directories,
+# both of which live under the omni/ prefix in S3.
+$PYTHON .buildkite/scripts/generate-nightly-index.py \
+    --version "$BUILDKITE_COMMIT" \
+    --current-objects "$obj_json" \
+    --output-dir "$INDICES_OUTPUT_DIR" \
+    --comment "commit $BUILDKITE_COMMIT"
+
+# copy indices to /omni/{commit}/ unconditionally
+echo "Uploading indices to $S3_COMMIT_PREFIX"
+aws s3 cp --recursive "$INDICES_OUTPUT_DIR/" "$S3_COMMIT_PREFIX"
+
+# copy to /omni/nightly/ when NIGHTLY=1
+if [[ "${NIGHTLY:-}" == "1" ]]; then
+    echo "Uploading indices to overwrite /omni/nightly/"
+    aws s3 cp --recursive "$INDICES_OUTPUT_DIR/" "s3://$BUCKET/omni/nightly/"
+fi
+
+# detect version from any wheel in the commit directory
+first_wheel_key=$($PYTHON -c "import json; obj=json.load(open('$obj_json')); print(next((c['Key'] for c in obj.get('Contents', []) if c['Key'].endswith('.whl')), ''))")
+if [[ -z "$first_wheel_key" ]]; then
+    echo "Error: No wheels found in $S3_COMMIT_PREFIX"
+    exit 1
+fi
+first_wheel=$(basename "$first_wheel_key")
+aws s3 cp "s3://$BUCKET/${first_wheel_key}" "/tmp/${first_wheel}"
+version=$(unzip -p "/tmp/${first_wheel}" '**/METADATA' | grep '^Version: ' | cut -d' ' -f2)
+rm -f "/tmp/${first_wheel}"
+echo "Version in wheel: $version"
+pure_version="${version%%+*}"
+echo "Pure version (without variant): $pure_version"
+
+# re-generate and copy to /omni/{version}/ only if it does not have "dev" in the version
+if [[ "$version" != *"dev"* ]]; then
+    echo "Re-generating indices for /omni/$pure_version/"
+    rm -rf "${INDICES_OUTPUT_DIR:?}"
+    mkdir -p "$INDICES_OUTPUT_DIR"
+    # wheel-dir is overridden to be the commit directory, so that the indices point to the correct wheel path
+    $PYTHON .buildkite/scripts/generate-nightly-index.py \
+        --version "$pure_version" \
+        --wheel-dir "$BUILDKITE_COMMIT" \
+        --current-objects "$obj_json" \
+        --output-dir "$INDICES_OUTPUT_DIR" \
+        --comment "version $pure_version"
+    aws s3 cp --recursive "$INDICES_OUTPUT_DIR/" "s3://$BUCKET/omni/$pure_version/"
+fi
diff --git a/.buildkite/scripts/generate-nightly-index.py b/.buildkite/scripts/generate-nightly-index.py
new file mode 100755
index 00000000000..c616c446b09
--- /dev/null
+++ b/.buildkite/scripts/generate-nightly-index.py
@@ -0,0 +1,193 @@
+#!/usr/bin/env python3
+# SPDX-License-Identifier: Apache-2.0
+# SPDX-FileCopyrightText: Copyright contributors to the vLLM project
+
+import argparse
+import json
+import sys
+from dataclasses import asdict, dataclass
+from datetime import datetime
+from pathlib import Path
+from typing import Any
+from urllib.parse import quote
+
+import regex as re
+
+
+def normalize_package_name(name: str) -> str:
+    """Normalize package name per PEP 503."""
+    return re.sub(r"[-_.]+", "-", name).lower()
+
+
+if not sys.version_info >= (3, 12):
+    raise RuntimeError("This script requires Python 3.12 or higher.")
+
+INDEX_HTML_TEMPLATE = """<!DOCTYPE html>
+<html>
+  <!-- {comment} -->
+  <meta name="pypi:repository-version" content="1.0">
+  <body>
+{items}
+  </body>
+</html>
+"""
+
+
+@dataclass
+class WheelFileInfo:
+    package_name: str
+    version: str
+    build_tag: str | None
+    python_tag: str
+    abi_tag: str
+    platform_tag: str
+    filename: str
+
+
+def parse_from_filename(file: str) -> WheelFileInfo:
+    """
+    Parse wheel filename per PEP 427:
+        {package_name}-{version}(-{build_tag})?-{python_tag}-{abi_tag}-{platform_tag}.whl
+    """
+    wheel_file_re = re.compile(
+        r"^(?P<package_name>.+)-(?P<version>[^-]+?)(-(?P<build_tag>[^-]+))?-(?P<python_tag>[^-]+)-(?P<abi_tag>[^-]+)-(?P<platform_tag>[^-]+)\.whl$"
+    )
+    match = wheel_file_re.match(file)
+    if not match:
+        raise ValueError(f"Invalid wheel file name: {file}")
+
+    return WheelFileInfo(
+        package_name=match.group("package_name"),
+        version=match.group("version"),
+        build_tag=match.group("build_tag"),
+        python_tag=match.group("python_tag"),
+        abi_tag=match.group("abi_tag"),
+        platform_tag=match.group("platform_tag"),
+        filename=file,
+    )
+
+
+def generate_project_list(package_names: list[str], comment: str = "") -> str:
+    """Generate top-level PEP 503 project list HTML."""
+    href_tags = []
+    for name in sorted(package_names):
+        href_tags.append(f'    <a href="{name}/">{name}/</a><br/>')
+    return INDEX_HTML_TEMPLATE.format(items="\n".join(href_tags), comment=comment)
+
+
+def generate_package_index(
+    wheel_files: list[WheelFileInfo],
+    wheel_base_dir: Path,
+    index_base_dir: Path,
+    comment: str = "",
+) -> tuple[str, str]:
+    """Generate package index HTML and metadata JSON linking to wheel files."""
+    href_tags = []
+    metadata = []
+    for file in sorted(wheel_files, key=lambda x: x.filename):
+        relative_path = wheel_base_dir.relative_to(index_base_dir, walk_up=True) / file.filename
+        # handle '+' in URL; avoid double-encoding '/' and '%2B' (AWS S3 behavior)
+        file_path_quoted = quote(relative_path.as_posix(), safe=":%/")
+        href_tags.append(f'    <a href="{file_path_quoted}">{file.filename}</a><br/>')
+        file_meta = asdict(file)
+        file_meta["path"] = file_path_quoted
+        metadata.append(file_meta)
+    index_str = INDEX_HTML_TEMPLATE.format(items="\n".join(href_tags), comment=comment)
+    metadata_str = json.dumps(metadata, indent=2)
+    return index_str, metadata_str
+
+
+def generate_index(
+    whl_files: list[str],
+    wheel_base_dir: Path,
+    index_base_dir: Path,
+    comment: str = "",
+):
+    """
+    Generate PEP 503 index for all wheel files.
+
+    Output structure:
+        index_base_dir/
+            index.html          # project list linking to vllm-omni/
+            vllm-omni/
+                index.html      # package index linking to wheel files
+                metadata.json   # machine-readable metadata
+    """
+    parsed_files = [parse_from_filename(f) for f in whl_files]
+
+    if not parsed_files:
+        print("No wheel files found, skipping index generation.")
+        return
+
+    comment_str = f" ({comment})" if comment else ""
+    comment_tmpl = f"Generated on {datetime.now().isoformat()}{comment_str}"
+
+    # Group by normalized package name
+    packages: dict[str, list[WheelFileInfo]] = {}
+    for file in parsed_files:
+        name = normalize_package_name(file.package_name)
+        packages.setdefault(name, []).append(file)
+
+    print(f"Found packages: {list(packages.keys())}")
+
+    # Generate per-package index
+    for package, files in packages.items():
+        package_dir = index_base_dir / package
+        package_dir.mkdir(parents=True, exist_ok=True)
+        index_str, metadata_str = generate_package_index(files, wheel_base_dir, package_dir, comment)
+        with open(package_dir / "index.html", "w") as f:
+            f.write(index_str)
+        with open(package_dir / "metadata.json", "w") as f:
+            f.write(metadata_str)
+
+    # Generate top-level project list
+    project_list_str = generate_project_list(sorted(packages.keys()), comment_tmpl)
+    with open(index_base_dir / "index.html", "w") as f:
+        f.write(project_list_str)
+
+
+if __name__ == "__main__":
+    parser = argparse.ArgumentParser(description="Generate PEP 503 wheel index from S3 object listing.")
+    parser.add_argument("--version", type=str, required=True, help="Version string (e.g., commit hash)")
+    parser.add_argument("--current-objects", type=str, required=True, help="Path to JSON from S3 list-objects-v2")
+    parser.add_argument("--output-dir", type=str, required=True, help="Directory to write index files")
+    parser.add_argument("--wheel-dir", type=str, default=None, help="Wheel directory (defaults to --version)")
+    parser.add_argument("--comment", type=str, default="", help="Comment for generated HTML")
+
+    args = parser.parse_args()
+
+    version = args.version
+    if "\\" in version or "/" in version:
+        raise ValueError("Version string must not contain slashes or backslashes.")
+
+    output_dir = Path(args.output_dir)
+    output_dir.mkdir(parents=True, exist_ok=True)
+
+    with open(args.current_objects) as f:
+        current_objects: dict[str, list[dict[str, Any]]] = json.load(f)
+
+    wheel_files = [
+        item["Key"].split("/")[-1] for item in current_objects.get("Contents", []) if item["Key"].endswith(".whl")
+    ]
+
+    print(f"Found {len(wheel_files)} wheel files for version {version}: {wheel_files}")
+
+    # For release versions, filter to only matching non-dev wheels
+    PY_VERSION_RE = re.compile(r"^\d+\.\d+\.\d+([a-zA-Z0-9.+-]*)?$")
+    if PY_VERSION_RE.match(version):
+        wheel_files = [f for f in wheel_files if version in f and "dev" not in f]
+        print(f"Non-nightly version detected, wheel files used: {wheel_files}")
+    else:
+        print("Nightly version detected, keeping all wheel files.")
+
+    wheel_dir = (args.wheel_dir or version).strip().rstrip("/")
+    wheel_base_dir = Path(output_dir).parent / wheel_dir
+    index_base_dir = Path(output_dir)
+
+    generate_index(
+        whl_files=wheel_files,
+        wheel_base_dir=wheel_base_dir,
+        index_base_dir=index_base_dir,
+        comment=args.comment.strip(),
+    )
+    print(f"Successfully generated index in {output_dir}")
diff --git a/.buildkite/scripts/upload-nightly-wheels.sh b/.buildkite/scripts/upload-nightly-wheels.sh
new file mode 100755
index 00000000000..d50da1deda1
--- /dev/null
+++ b/.buildkite/scripts/upload-nightly-wheels.sh
@@ -0,0 +1,33 @@
+#!/usr/bin/env bash
+
+set -ex
+
+# Upload a single wheel to S3 under the omni/ prefix.
+# Index generation is handled separately by generate-and-upload-nightly-index.sh.
+
+BUCKET="vllm-wheels"
+SUBPATH="omni/$BUILDKITE_COMMIT"
+S3_COMMIT_PREFIX="s3://$BUCKET/$SUBPATH/"
+
+# ========= collect & upload the wheel ==========
+
+# python3 -m build outputs to dist/ by default
+wheel_files=(dist/*.whl)
+
+# Check that exactly one wheel is found
+if [[ ${#wheel_files[@]} -ne 1 ]]; then
+  echo "Error: Expected exactly one wheel file in dist/, but found ${#wheel_files[@]}"
+  exit 1
+fi
+wheel="${wheel_files[0]}"
+
+echo "Uploading wheel: $wheel"
+
+# Extract the version from the wheel
+version=$(unzip -p "$wheel" '**/METADATA' | grep '^Version: ' | cut -d' ' -f2)
+echo "Version in wheel: $version"
+
+# Upload wheel to S3
+aws s3 cp "$wheel" "$S3_COMMIT_PREFIX"
+
+echo "Wheel uploaded to $S3_COMMIT_PREFIX. Index generation is handled by a separate step."