diff --git a/.github/workflows/ci-changes.yml b/.github/workflows/ci-changes.yml
index 5f5d2efc66..3f22241a71 100644
--- a/.github/workflows/ci-changes.yml
+++ b/.github/workflows/ci-changes.yml
@@ -35,6 +35,8 @@ on:
         value: ${{ jobs.filter.outputs.e2e_routing_strategies }}
       e2e_production_stack:
         value: ${{ jobs.filter.outputs.e2e_production_stack }}
+      e2e_response_api:
+        value: ${{ jobs.filter.outputs.e2e_response_api }}
       e2e_common:
         value: ${{ jobs.filter.outputs.e2e_common }}
 
@@ -59,6 +61,7 @@ jobs:
       e2e_llm_d: ${{ steps.changes.outputs.e2e_llm_d }}
       e2e_routing_strategies: ${{ steps.changes.outputs.e2e_routing_strategies }}
       e2e_production_stack: ${{ steps.changes.outputs.e2e_production_stack }}
+      e2e_response_api: ${{ steps.changes.outputs.e2e_response_api }}
       e2e_common: ${{ steps.changes.outputs.e2e_common }}
     steps:
       - uses: actions/checkout@v4
@@ -131,6 +134,8 @@ jobs:
               - 'deploy/kubernetes/routing-strategies/**'
             e2e_production_stack:
               - 'e2e/profiles/production-stack/**'
+            e2e_response_api:
+              - 'e2e/profiles/response-api/**'
             # Common e2e code that affects all profiles
             e2e_common:
               - 'e2e/pkg/**'
diff --git a/.github/workflows/integration-test-k8s.yml b/.github/workflows/integration-test-k8s.yml
index 03bce54e43..a746fcbc93 100644
--- a/.github/workflows/integration-test-k8s.yml
+++ b/.github/workflows/integration-test-k8s.yml
@@ -40,7 +40,7 @@ jobs:
              [[ "${{ needs.changes.outputs.core }}" == "true" ]] || \
              [[ "${{ github.event_name }}" == "schedule" ]] || \
              [[ "${{ github.event_name }}" == "workflow_dispatch" ]]; then
-            echo 'profiles=["ai-gateway", "aibrix", "routing-strategies", "dynamic-config", "llm-d", "istio", "production-stack"]' >> $GITHUB_OUTPUT
+            echo 'profiles=["ai-gateway", "aibrix", "routing-strategies", "dynamic-config", "llm-d", "istio", "production-stack", "response-api"]' >> $GITHUB_OUTPUT
             echo 'should_run=true' >> $GITHUB_OUTPUT
             echo "Running all profiles due to common/core changes or push/schedule/manual trigger"
             exit 0
@@ -55,6 +55,7 @@ jobs:
           [[ "${{ needs.changes.outputs.e2e_routing_strategies }}" == "true" ]] && profiles+=("routing-strategies")
           [[ "${{ needs.changes.outputs.e2e_production_stack }}" == "true" ]] && profiles+=("production-stack")
           [[ "${{ needs.changes.outputs.e2e_dynamic_config }}" == "true" ]] && profiles+=("dynamic-config")
+          [[ "${{ needs.changes.outputs.e2e_response_api }}" == "true" ]] && profiles+=("response-api")
 
           # Convert to JSON array
           if [ ${#profiles[@]} -eq 0 ]; then