diff --git a/go/cmd/vttestserver/data/schema/app_customer/v001__create_customer_table.sql b/go/cmd/vttestserver/data/schema/app_customer/v001__create_customer_table.sql
new file mode 100644
index 00000000000..25eb226f006
--- /dev/null
+++ b/go/cmd/vttestserver/data/schema/app_customer/v001__create_customer_table.sql
@@ -0,0 +1,7 @@
+create table customers (
+  id bigint,
+  name varchar(64),
+  age SMALLINT,
+  primary key (id)
+) Engine=InnoDB;
+
diff --git a/go/cmd/vttestserver/data/schema/app_customer/v002__add_customer_vschema.sql b/go/cmd/vttestserver/data/schema/app_customer/v002__add_customer_vschema.sql
new file mode 100644
index 00000000000..300e7e9e41e
--- /dev/null
+++ b/go/cmd/vttestserver/data/schema/app_customer/v002__add_customer_vschema.sql
@@ -0,0 +1 @@
+alter vschema on customers add vindex hash (id);
\ No newline at end of file
diff --git a/go/cmd/vttestserver/data/schema/app_customer/vschema.json b/go/cmd/vttestserver/data/schema/app_customer/vschema.json
new file mode 100644
index 00000000000..cdeb6545df9
--- /dev/null
+++ b/go/cmd/vttestserver/data/schema/app_customer/vschema.json
@@ -0,0 +1,10 @@
+{
+  "sharded": true,
+  "vindexes": {
+    "hash": {
+      "type": "hash"
+    }
+  },
+  "tables": {
+  }
+}
\ No newline at end of file
diff --git a/go/cmd/vttestserver/data/schema/test_keyspace/v001__create_test_table.sql b/go/cmd/vttestserver/data/schema/test_keyspace/v001__create_test_table.sql
new file mode 100644
index 00000000000..e0ef23320ee
--- /dev/null
+++ b/go/cmd/vttestserver/data/schema/test_keyspace/v001__create_test_table.sql
@@ -0,0 +1,12 @@
+create table test_table (
+  id bigint,
+  name varchar(64),
+  age SMALLINT,
+  percent DECIMAL(5,2),
+  datetime_col DATETIME,
+  timestamp_col TIMESTAMP,
+  date_col DATE,
+  time_col TIME,
+  primary key (id)
+) Engine=InnoDB;
+
diff --git a/go/cmd/vttestserver/data/schema/test_keyspace/v002__create_hash_vindex.sql b/go/cmd/vttestserver/data/schema/test_keyspace/v002__create_hash_vindex.sql
new file mode 100644
index 00000000000..f1333a384fa
--- /dev/null
+++ b/go/cmd/vttestserver/data/schema/test_keyspace/v002__create_hash_vindex.sql
@@ -0,0 +1 @@
+alter vschema create vindex my_vdx using hash
\ No newline at end of file
diff --git a/go/cmd/vttestserver/data/schema/test_keyspace/v003__add_table_vschema.sql b/go/cmd/vttestserver/data/schema/test_keyspace/v003__add_table_vschema.sql
new file mode 100644
index 00000000000..7cdccd02077
--- /dev/null
+++ b/go/cmd/vttestserver/data/schema/test_keyspace/v003__add_table_vschema.sql
@@ -0,0 +1 @@
+alter vschema on test_table add vindex my_vdx (id)
\ No newline at end of file
diff --git a/go/cmd/vttestserver/data/schema/test_keyspace/v004__create_test_table1.sql b/go/cmd/vttestserver/data/schema/test_keyspace/v004__create_test_table1.sql
new file mode 100644
index 00000000000..79aea4379ab
--- /dev/null
+++ b/go/cmd/vttestserver/data/schema/test_keyspace/v004__create_test_table1.sql
@@ -0,0 +1,11 @@
+create table test_table1 (
+  id bigint,
+  name varchar(64),
+  age SMALLINT,
+  percent DECIMAL(5,2),
+  datetime_col DATETIME,
+  timestamp_col TIMESTAMP,
+  date_col DATE,
+  time_col TIME,
+  primary key (id)
+) Engine=InnoDB;
\ No newline at end of file
diff --git a/go/cmd/vttestserver/main.go b/go/cmd/vttestserver/main.go
index 55052b1b603..e6280af194e 100644
--- a/go/cmd/vttestserver/main.go
+++ b/go/cmd/vttestserver/main.go
@@ -199,32 +199,34 @@ func parseFlags() (config vttest.Config, env vttest.Environment, err error) {
 }
 
 func main() {
+	cluster := runCluster()
+	defer cluster.TearDown()
+
+	kvconf := cluster.JSONConfig()
+	if err := json.NewEncoder(os.Stdout).Encode(kvconf); err != nil {
+		log.Fatal(err)
+	}
+
+	select {}
+}
+
+func runCluster() vttest.LocalCluster {
 	config, env, err := parseFlags()
 	if err != nil {
 		log.Fatal(err)
 	}
-
 	log.Infof("Starting local cluster...")
 	log.Infof("config: %#v", config)
-
 	cluster := vttest.LocalCluster{
 		Config: config,
 		Env:    env,
 	}
-
 	err = cluster.Setup()
-	defer cluster.TearDown()
-
 	if err != nil {
 		log.Fatal(err)
 	}
 
-	kvconf := cluster.JSONConfig()
-	if err := json.NewEncoder(os.Stdout).Encode(kvconf); err != nil {
-		log.Fatal(err)
-	}
-
 	log.Info("Local cluster started.")
 
-	select {}
+	return cluster
 }
diff --git a/go/cmd/vttestserver/vttestserver_test.go b/go/cmd/vttestserver/vttestserver_test.go
new file mode 100644
index 00000000000..79d246efbfa
--- /dev/null
+++ b/go/cmd/vttestserver/vttestserver_test.go
@@ -0,0 +1,68 @@
+package main
+
+import (
+	"context"
+	"fmt"
+	"os"
+	"testing"
+
+	"vitess.io/vitess/go/vt/vttest"
+
+	"github.com/golang/protobuf/jsonpb"
+	"vitess.io/vitess/go/vt/proto/logutil"
+	"vitess.io/vitess/go/vt/proto/vschema"
+	"vitess.io/vitess/go/vt/vtctl/vtctlclient"
+)
+
+type columnVindex struct {
+	keyspace   string
+	table      string
+	vindex     string
+	vindexType string
+	column     string
+}
+
+func TestRunsVschemaMigrations(t *testing.T) {
+	schemaDirArg := "-schema_dir=data/schema"
+	webDirArg := "-web_dir=web/vtctld/app"
+	webDir2Arg := "-web_dir2=web/vtctld2/app"
+	tabletHostname := "-tablet_hostname=localhost"
+	keyspaceArg := "-keyspaces=test_keyspace,app_customer"
+	numShardsArg := "-num_shards=2,2"
+
+	os.Args = append(os.Args, []string{schemaDirArg, keyspaceArg, numShardsArg, webDirArg, webDir2Arg, tabletHostname}...)
+
+	cluster := runCluster()
+	defer cluster.TearDown()
+
+	assertColumnVindex(t, cluster, columnVindex{keyspace: "test_keyspace", table: "test_table", vindex: "my_vdx", vindexType: "hash", column: "id"})
+	assertColumnVindex(t, cluster, columnVindex{keyspace: "app_customer", table: "customers", vindex: "hash", vindexType: "hash", column: "id"})
+}
+
+func assertColumnVindex(t *testing.T, cluster vttest.LocalCluster, expected columnVindex) {
+	server := fmt.Sprintf("localhost:%v", cluster.GrpcPort())
+	args := []string{"GetVSchema", expected.keyspace}
+	ctx := context.Background()
+
+	err := vtctlclient.RunCommandAndWait(ctx, server, args, func(e *logutil.Event) {
+		var keyspace vschema.Keyspace
+		if err := jsonpb.UnmarshalString(e.Value, &keyspace); err != nil {
+			t.Error(err)
+		}
+
+		columnVindex := keyspace.Tables[expected.table].ColumnVindexes[0]
+		actualVindex := keyspace.Vindexes[expected.vindex]
+		assertEqual(t, actualVindex.Type, expected.vindexType, "Actual vindex type different from expected")
+		assertEqual(t, columnVindex.Name, expected.vindex, "Actual vindex name different from expected")
+		assertEqual(t, columnVindex.Columns[0], expected.column, "Actual vindex column different from expected")
+	})
+	if err != nil {
+		t.Error(err)
+	}
+}
+
+func assertEqual(t *testing.T, actual string, expected string, message string) {
+	if actual != expected {
+		t.Errorf("%s: actual %s, expected %s", message, actual, expected)
+	}
+}
diff --git a/go/vt/vtgate/endtoend/deletetest/delete_test.go b/go/vt/vtgate/endtoend/deletetest/delete_test.go
index 647556cb151..9f0cb6ceb79 100644
--- a/go/vt/vtgate/endtoend/deletetest/delete_test.go
+++ b/go/vt/vtgate/endtoend/deletetest/delete_test.go
@@ -32,10 +32,11 @@ import (
 )
 
 var (
-	cluster     *vttest.LocalCluster
-	vtParams    mysql.ConnParams
-	mysqlParams mysql.ConnParams
-	grpcAddress string
+	cluster        *vttest.LocalCluster
+	vtParams       mysql.ConnParams
+	mysqlParams    mysql.ConnParams
+	grpcAddress    string
+	tabletHostName = flag.String("tablet_hostname", "", "the tablet hostname")
 
 	schema = `
 create table t1(
@@ -134,6 +135,8 @@ func TestMain(m *testing.M) {
 		}
 		defer os.RemoveAll(cfg.SchemaDir)
 
+		cfg.TabletHostName = *tabletHostName
+
 		cluster = &vttest.LocalCluster{
 			Config: cfg,
 		}
diff --git a/go/vt/vtgate/endtoend/main_test.go b/go/vt/vtgate/endtoend/main_test.go
index bfc17878101..da52636dcec 100644
--- a/go/vt/vtgate/endtoend/main_test.go
+++ b/go/vt/vtgate/endtoend/main_test.go
@@ -32,10 +32,11 @@ import (
 )
 
 var (
-	cluster     *vttest.LocalCluster
-	vtParams    mysql.ConnParams
-	mysqlParams mysql.ConnParams
-	grpcAddress string
+	cluster        *vttest.LocalCluster
+	vtParams       mysql.ConnParams
+	mysqlParams    mysql.ConnParams
+	grpcAddress    string
+	tabletHostName = flag.String("tablet_hostname", "", "the tablet hostname")
 
 	schema = `
 create table t1(
@@ -178,6 +179,8 @@ func TestMain(m *testing.M) {
 		}
 		defer os.RemoveAll(cfg.SchemaDir)
 
+		cfg.TabletHostName = *tabletHostName
+
 		cluster = &vttest.LocalCluster{
 			Config: cfg,
 		}
diff --git a/go/vt/vttest/local_cluster.go b/go/vt/vttest/local_cluster.go
index 2923ceaf461..8532052dded 100644
--- a/go/vt/vttest/local_cluster.go
+++ b/go/vt/vttest/local_cluster.go
@@ -30,6 +30,12 @@ import (
 	"strings"
 	"unicode"
 
+	"vitess.io/vitess/go/vt/proto/logutil"
+	// we need to import the grpcvtctlclient library so the gRPC
+	// vtctl client is registered and can be used.
+	_ "vitess.io/vitess/go/vt/vtctl/grpcvtctlclient"
+	"vitess.io/vitess/go/vt/vtctl/vtctlclient"
+
 	"vitess.io/vitess/go/mysql"
 	"vitess.io/vitess/go/sqltypes"
 	"vitess.io/vitess/go/vt/log"
@@ -238,6 +244,16 @@ func (db *LocalCluster) Setup() error {
 		return err
 	}
 
+	if !db.OnlyMySQL {
+		log.Infof("Starting vtcombo...")
+		db.vt = VtcomboProcess(db.Env, &db.Config, db.mysql)
+		if err := db.vt.WaitStart(); err != nil {
+			return err
+		}
+		log.Infof("vtcombo up: %s", db.vt.Address())
+	}
+
+	// Load schema will apply db and vschema migrations. Running after vtcombo starts to be able to apply vschema migrations
 	if err := db.loadSchema(); err != nil {
 		return err
 	}
@@ -248,15 +264,6 @@ func (db *LocalCluster) Setup() error {
 		}
 	}
 
-	if !db.OnlyMySQL {
-		log.Infof("Starting vtcombo...")
-		db.vt = VtcomboProcess(db.Env, &db.Config, db.mysql)
-		if err := db.vt.WaitStart(); err != nil {
-			return err
-		}
-		log.Infof("vtcombo up: %s", db.vt.Address())
-	}
-
 	return nil
 }
 
@@ -310,6 +317,7 @@ func isDir(path string) bool {
 	return err == nil && info.IsDir()
 }
 
+// loadSchema applies sql and vschema migrations respectively for each keyspace in the topology
 func (db *LocalCluster) loadSchema() error {
 	if db.SchemaDir == "" {
 		return nil
@@ -345,12 +353,26 @@ func (db *LocalCluster) loadSchema() error {
 				return err
 			}
 
+			// One single vschema migration per file
+			if !db.OnlyMySQL && len(cmds) == 1 && strings.HasPrefix(strings.ToUpper(cmds[0]), "ALTER VSCHEMA") {
+				if err = db.applyVschema(keyspace, cmds[0]); err != nil {
+					return err
+				}
+				continue
+			}
+
 			for _, dbname := range db.shardNames(kpb) {
 				if err := db.Execute(cmds, dbname); err != nil {
 					return err
 				}
 			}
 		}
+
+		if !db.OnlyMySQL {
+			if err := db.reloadSchemaKeyspace(keyspace); err != nil {
+				return err
+			}
+		}
 	}
 
 	return nil
@@ -435,6 +457,34 @@ func (db *LocalCluster) JSONConfig() interface{} {
 	return config
 }
 
+// GrpcPort returns the grpc port used by vtcombo
+func (db *LocalCluster) GrpcPort() int {
+	return db.vt.PortGrpc
+}
+
+func (db *LocalCluster) applyVschema(keyspace string, migration string) error {
+	server := fmt.Sprintf("localhost:%v", db.vt.PortGrpc)
+	args := []string{"ApplyVSchema", "-sql", migration, keyspace}
+	fmt.Printf("Applying vschema %v", args)
+	err := vtctlclient.RunCommandAndWait(context.Background(), server, args, func(e *logutil.Event) {
+		log.Info(e)
+	})
+
+	return err
+}
+
+func (db *LocalCluster) reloadSchemaKeyspace(keyspace string) error {
+	server := fmt.Sprintf("localhost:%v", db.vt.PortGrpc)
+	args := []string{"ReloadSchemaKeyspace", "-include_master=true", keyspace}
+	fmt.Printf("Reloading keyspace schema %v", args)
+
+	err := vtctlclient.RunCommandAndWait(context.Background(), server, args, func(e *logutil.Event) {
+		log.Info(e)
+	})
+
+	return err
+}
+
 // LoadSQLFile loads a parses a .sql file from disk, removing all the
 // different comments that mysql/mysqldump inserts in these, and returning
 // each individual SQL statement as its own string.