diff --git a/packages/vite/src/node/plugins/oxc.ts b/packages/vite/src/node/plugins/oxc.ts
index e0e30e8224d7b9..cea5f7778a343b 100644
--- a/packages/vite/src/node/plugins/oxc.ts
+++ b/packages/vite/src/node/plugins/oxc.ts
@@ -18,6 +18,7 @@ import type { ViteDevServer } from '../server'
 import { JS_TYPES_RE, VITE_PACKAGE_DIR } from '../constants'
 import type { Logger } from '../logger'
 import { type ESBuildOptions, getTSConfigResolutionCache } from './esbuild'
+import { getRealPath } from './resolve'
 
 // IIFE content looks like `var MyLib = (function() {` or `this.nested.myLib = (function() {`.
 export const IIFE_BEGIN_RE: RegExp =
@@ -299,8 +300,9 @@ export function oxcPlugin(config: ResolvedConfig): Plugin {
 
     return result
   }
-  const runtimeResolveBase = normalizePath(
-    path.join(VITE_PACKAGE_DIR, 'package.json'),
+  const runtimePackageDir = getRealPath(
+    path.join(VITE_PACKAGE_DIR, 'node_modules', '@oxc-project', 'runtime'),
+    config.resolve.preserveSymlinks,
   )
 
   let server: ViteDevServer
@@ -315,13 +317,22 @@ export function oxcPlugin(config: ResolvedConfig): Plugin {
       ? {
           resolveId: {
             filter: {
-              id: prefixRegex('@oxc-project/runtime/'),
+              id: prefixRegex('@oxc-project/runtime/helpers/'),
             },
-            async handler(id, _importer, opts) {
+            async handler(id, _importer, _opts) {
               // @oxc-project/runtime imports will be injected by Oxc transform
               // since it's injected by the transform, @oxc-project/runtime should be resolved to the one Vite depends on
-              const resolved = await this.resolve(id, runtimeResolveBase, opts)
-              return resolved
+              const helperName = id.slice(
+                '@oxc-project/runtime/helpers/'.length,
+              )
+              // Rolldown always uses the esm version of @oxc-project/runtime
+              // https://github.com/rolldown/rolldown/blob/v1.0.0-rc.9/crates/rolldown_plugin_oxc_runtime/src/lib.rs#L27
+              const helperId = path.posix.join(
+                runtimePackageDir,
+                'src/helpers/esm',
+                helperName + (id.endsWith('.js') ? '' : '.js'),
+              )
+              return helperId
             },
             order: 'pre',
           },
diff --git a/packages/vite/src/node/plugins/resolve.ts b/packages/vite/src/node/plugins/resolve.ts
index 89ed17efaac477..26a233ed635d98 100644
--- a/packages/vite/src/node/plugins/resolve.ts
+++ b/packages/vite/src/node/plugins/resolve.ts
@@ -1218,7 +1218,10 @@ function tryResolveRealFileOrType(
   return
 }
 
-function getRealPath(resolved: string, preserveSymlinks?: boolean): string {
+export function getRealPath(
+  resolved: string,
+  preserveSymlinks?: boolean,
+): string {
   if (!preserveSymlinks) {
     resolved = safeRealpathSync(resolved)
   }
diff --git a/packages/vite/src/node/ssr/runtime/__tests__/fixtures/oxc-runtime-helper.ts b/packages/vite/src/node/ssr/runtime/__tests__/fixtures/oxc-runtime-helper.ts
new file mode 100644
index 00000000000000..c4e5d4d23c5fec
--- /dev/null
+++ b/packages/vite/src/node/ssr/runtime/__tests__/fixtures/oxc-runtime-helper.ts
@@ -0,0 +1,6 @@
+function html(strings: TemplateStringsArray, ...values: unknown[]) {
+  return strings.join('')
+}
+export const result = html`<script>
+  console.log('hi')
+</script>`
diff --git a/packages/vite/src/node/ssr/runtime/__tests__/server-runtime.spec.ts b/packages/vite/src/node/ssr/runtime/__tests__/server-runtime.spec.ts
index 5114dab3b593bc..b659dd67f9f6c3 100644
--- a/packages/vite/src/node/ssr/runtime/__tests__/server-runtime.spec.ts
+++ b/packages/vite/src/node/ssr/runtime/__tests__/server-runtime.spec.ts
@@ -12,6 +12,7 @@ describe('module runner initialization', async () => {
   const it = await createModuleRunnerTester({
     resolve: {
       external: ['tinyglobby'],
+      noExternal: ['@oxc-project/runtime'],
     },
   })
 
@@ -396,6 +397,15 @@ describe('module runner initialization', async () => {
     )
   })
 
+  it('oxc runtime helpers are loadable', async ({ runner }) => {
+    const mod = await runner.import('/fixtures/oxc-runtime-helper.ts')
+    expect(mod.result).toMatchInlineSnapshot(`
+      "<script>
+        console.log('hi')
+      </script>"
+    `)
+  })
+
   it(`handle Object variable`, async ({ runner }) => {
     const mod = await runner.import('/fixtures/top-level-object.js')
     expect(mod).toMatchInlineSnapshot(`