diff --git a/packages/vite/src/node/config.ts b/packages/vite/src/node/config.ts
index b4dfbdebbd9d20..2273eb36b49b95 100644
--- a/packages/vite/src/node/config.ts
+++ b/packages/vite/src/node/config.ts
@@ -2315,6 +2315,9 @@ async function bundleConfigFile(
     },
     // disable treeshake to include files that is not sideeffectful to `moduleIds`
     treeshake: false,
+    // disable tsconfig as it's confusing to respect tsconfig options in the config file
+    // this also aligns with other config loader behaviors
+    tsconfig: false,
     plugins: [
       {
         name: 'externalize-deps',