diff --git a/packages/date-picker/src/vaadin-date-picker-mixin.js b/packages/date-picker/src/vaadin-date-picker-mixin.js
index a556ca9f877..44cd1b89e36 100644
--- a/packages/date-picker/src/vaadin-date-picker-mixin.js
+++ b/packages/date-picker/src/vaadin-date-picker-mixin.js
@@ -616,6 +616,24 @@ export const DatePickerMixin = (subclass) =>
       return !this._shouldKeepFocusRing;
     }
 
+    /**
+     * Override method inherited from `ClearButtonMixin`
+     * to not blur on clear button mousedown when opened
+     * so that focus remains in the input field.
+     *
+     * @param {Event} event
+     * @return {boolean}
+     * @protected
+     * @override
+     */
+    _shouldKeepFocusOnClearMousedown(event) {
+      if (this.opened) {
+        return true;
+      }
+
+      return super._shouldKeepFocusOnClearMousedown(event);
+    }
+
     /**
      * Override method inherited from `FocusMixin`
      * to prevent removing the `focused` attribute:
diff --git a/packages/date-picker/test/basic.test.js b/packages/date-picker/test/basic.test.js
index be12b5aafe0..79a4d5a7b33 100644
--- a/packages/date-picker/test/basic.test.js
+++ b/packages/date-picker/test/basic.test.js
@@ -362,6 +362,30 @@ describe('clear button', () => {
     click(clearButton);
     expect(datePicker.opened).to.be.not.ok;
   });
+
+  it('should not prevent default on clear button mousedown if input is not focused', () => {
+    datePicker.value = '2001-01-01';
+    const event = new CustomEvent('mousedown', { cancelable: true });
+    clearButton.dispatchEvent(event);
+    expect(event.defaultPrevented).to.be.false;
+  });
+
+  it('should prevent default on clear button mousedown if input is focused', () => {
+    datePicker.value = '2001-01-01';
+    datePicker.inputElement.focus();
+    const event = new CustomEvent('mousedown', { cancelable: true });
+    clearButton.dispatchEvent(event);
+    expect(event.defaultPrevented).to.be.true;
+  });
+
+  it('should prevent default on clear button mousedown when opened', async () => {
+    datePicker.value = '2001-01-01';
+    await open(datePicker);
+    datePicker.inputElement.blur();
+    const event = new CustomEvent('mousedown', { cancelable: true });
+    clearButton.dispatchEvent(event);
+    expect(event.defaultPrevented).to.be.true;
+  });
 });
 
 describe('initial value attribute', () => {
diff --git a/packages/field-base/src/clear-button-mixin.js b/packages/field-base/src/clear-button-mixin.js
index 0fe18bb8f94..c22f4192f34 100644
--- a/packages/field-base/src/clear-button-mixin.js
+++ b/packages/field-base/src/clear-button-mixin.js
@@ -3,6 +3,7 @@
  * Copyright (c) 2021 - 2025 Vaadin Ltd.
  * This program is available under Apache License Version 2.0, available at https://vaadin.com/license/
  */
+import { isElementFocused } from '@vaadin/a11y-base/src/focus-utils.js';
 import { KeyboardMixin } from '@vaadin/a11y-base/src/keyboard-mixin.js';
 import { isTouch } from '@vaadin/component-base/src/browser-utils.js';
 import { InputMixin } from './input-mixin.js';
@@ -71,7 +72,10 @@ export const ClearButtonMixin = (superclass) =>
      * @protected
      */
     _onClearButtonMouseDown(event) {
-      event.preventDefault();
+      if (this._shouldKeepFocusOnClearMousedown(event)) {
+        event.preventDefault();
+      }
+
       if (!isTouch) {
         this.inputElement.focus();
       }
@@ -109,4 +113,17 @@ export const ClearButtonMixin = (superclass) =>
       this.inputElement.dispatchEvent(new Event('input', { bubbles: true, composed: true }));
       this.inputElement.dispatchEvent(new Event('change', { bubbles: true }));
     }
+
+    /**
+     * Whether to keep focus inside the field on clear button
+     * mousedown. By default, if the field has focus, it gets
+     * preserved using `preventDefault()` on mousedown event
+     * in order to avoid blur and change events.
+     *
+     * @protected
+     * @return {boolean}
+     */
+    _shouldKeepFocusOnClearMousedown() {
+      return isElementFocused(this.inputElement);
+    }
   };
diff --git a/packages/field-base/test/clear-button-mixin.test.js b/packages/field-base/test/clear-button-mixin.test.js
index 2d4cb57ba8d..5f5a4e06709 100644
--- a/packages/field-base/test/clear-button-mixin.test.js
+++ b/packages/field-base/test/clear-button-mixin.test.js
@@ -67,7 +67,14 @@ describe('ClearButtonMixin', () => {
       expect(spy.calledOnce).to.be.true;
     });
 
-    it('should prevent default on clear button mousedown', () => {
+    it('should not prevent default on clear button mousedown if input is not focused', () => {
+      const event = new CustomEvent('mousedown', { cancelable: true });
+      clearButton.dispatchEvent(event);
+      expect(event.defaultPrevented).to.be.false;
+    });
+
+    it('should prevent default on clear button mousedown if input is focused', () => {
+      input.focus();
       const event = new CustomEvent('mousedown', { cancelable: true });
       clearButton.dispatchEvent(event);
       expect(event.defaultPrevented).to.be.true;