diff --git a/xchacha20poly1305.py b/xchacha20poly1305.py
index 5ef5d8e..d27a7f7 100644
--- a/xchacha20poly1305.py
+++ b/xchacha20poly1305.py
@@ -35,8 +35,16 @@
 
 import ctypes
 import ctypes.util
+from glob import glob
 
 library_path = ctypes.util.find_library("sodium") or ctypes.util.find_library("libsodium")
+# Workaround for bpo-21622: https://github.com/python/cpython/pull/18380
+if not library_path and glob("/lib/ld-musl-*.so*"):
+    library_path = glob("/usr/lib/libsodium.so*")[0]
+
+if not library_path:
+    raise RuntimeError("Unable to locate libsodium")
+
 sodium = ctypes.cdll.LoadLibrary(library_path)
 
 if not sodium._name: