diff --git a/plugin/trino-hive/src/main/java/io/trino/plugin/hive/s3/HiveS3Config.java b/plugin/trino-hive/src/main/java/io/trino/plugin/hive/s3/HiveS3Config.java
index d256eb1f37b9..22c2e2cbaffd 100644
--- a/plugin/trino-hive/src/main/java/io/trino/plugin/hive/s3/HiveS3Config.java
+++ b/plugin/trino-hive/src/main/java/io/trino/plugin/hive/s3/HiveS3Config.java
@@ -42,6 +42,7 @@ public class HiveS3Config
     private String s3AwsAccessKey;
     private String s3AwsSecretKey;
     private String s3Endpoint;
+    private String s3Region;
     private TrinoS3StorageClass s3StorageClass = TrinoS3StorageClass.STANDARD;
     private TrinoS3SignerType s3SignerType;
     private String s3SignerClass;
@@ -118,6 +119,18 @@ public HiveS3Config setS3Endpoint(String s3Endpoint)
         return this;
     }
 
+    public String getS3Region()
+    {
+        return s3Region;
+    }
+
+    @Config("hive.s3.region")
+    public HiveS3Config setS3Region(String s3Region)
+    {
+        this.s3Region = s3Region;
+        return this;
+    }
+
     @NotNull
     public TrinoS3StorageClass getS3StorageClass()
     {
diff --git a/plugin/trino-hive/src/main/java/io/trino/plugin/hive/s3/TrinoS3ConfigurationInitializer.java b/plugin/trino-hive/src/main/java/io/trino/plugin/hive/s3/TrinoS3ConfigurationInitializer.java
index 0dd7c9f5e59c..f6c4deaae96f 100644
--- a/plugin/trino-hive/src/main/java/io/trino/plugin/hive/s3/TrinoS3ConfigurationInitializer.java
+++ b/plugin/trino-hive/src/main/java/io/trino/plugin/hive/s3/TrinoS3ConfigurationInitializer.java
@@ -47,6 +47,7 @@
 import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_PROXY_PORT;
 import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_PROXY_PROTOCOL;
 import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_PROXY_USERNAME;
+import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_REGION;
 import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_REQUESTER_PAYS_ENABLED;
 import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_SECRET_KEY;
 import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_SIGNER_CLASS;
@@ -72,6 +73,7 @@ public class TrinoS3ConfigurationInitializer
     private final String awsAccessKey;
     private final String awsSecretKey;
     private final String endpoint;
+    private final String region;
     private final TrinoS3StorageClass s3StorageClass;
     private final TrinoS3SignerType signerType;
     private final boolean pathStyleAccess;
@@ -117,6 +119,7 @@ public TrinoS3ConfigurationInitializer(HiveS3Config config)
         this.awsAccessKey = config.getS3AwsAccessKey();
         this.awsSecretKey = config.getS3AwsSecretKey();
         this.endpoint = config.getS3Endpoint();
+        this.region = config.getS3Region();
         this.s3StorageClass = config.getS3StorageClass();
         this.signerType = config.getS3SignerType();
         this.signerClass = config.getS3SignerClass();
@@ -174,6 +177,9 @@ public void initializeConfiguration(Configuration config)
         if (endpoint != null) {
             config.set(S3_ENDPOINT, endpoint);
         }
+        if (region != null) {
+            config.set(S3_REGION, region);
+        }
         config.set(S3_STORAGE_CLASS, s3StorageClass.name());
         if (signerType != null) {
             config.set(S3_SIGNER_TYPE, signerType.name());
diff --git a/plugin/trino-hive/src/main/java/io/trino/plugin/hive/s3/TrinoS3FileSystem.java b/plugin/trino-hive/src/main/java/io/trino/plugin/hive/s3/TrinoS3FileSystem.java
index ac5f232d297e..793168d6139a 100644
--- a/plugin/trino-hive/src/main/java/io/trino/plugin/hive/s3/TrinoS3FileSystem.java
+++ b/plugin/trino-hive/src/main/java/io/trino/plugin/hive/s3/TrinoS3FileSystem.java
@@ -192,6 +192,7 @@ public class TrinoS3FileSystem
     public static final String S3_SIGNER_TYPE = "trino.s3.signer-type";
     public static final String S3_SIGNER_CLASS = "trino.s3.signer-class";
     public static final String S3_ENDPOINT = "trino.s3.endpoint";
+    public static final String S3_REGION = "trino.s3.region";
     public static final String S3_SECRET_KEY = "trino.s3.secret-key";
     public static final String S3_ACCESS_KEY = "trino.s3.access-key";
     public static final String S3_SESSION_TOKEN = "trino.s3.session-token";
@@ -920,7 +921,7 @@ private AmazonS3 createAmazonS3Client(Configuration hadoopConfig, ClientConfigur
 
         String endpoint = hadoopConfig.get(S3_ENDPOINT);
         if (endpoint != null) {
-            clientBuilder.setEndpointConfiguration(new EndpointConfiguration(endpoint, null));
+            clientBuilder.setEndpointConfiguration(new EndpointConfiguration(endpoint, hadoopConfig.get(S3_REGION)));
             regionOrEndpointSet = true;
         }
 
diff --git a/plugin/trino-hive/src/test/java/io/trino/plugin/hive/s3/TestHiveS3Config.java b/plugin/trino-hive/src/test/java/io/trino/plugin/hive/s3/TestHiveS3Config.java
index 111c5d3185a5..d07da3216533 100644
--- a/plugin/trino-hive/src/test/java/io/trino/plugin/hive/s3/TestHiveS3Config.java
+++ b/plugin/trino-hive/src/test/java/io/trino/plugin/hive/s3/TestHiveS3Config.java
@@ -41,6 +41,7 @@ public void testDefaults()
                 .setS3AwsAccessKey(null)
                 .setS3AwsSecretKey(null)
                 .setS3Endpoint(null)
+                .setS3Region(null)
                 .setS3SignerType(null)
                 .setS3SignerClass(null)
                 .setS3PathStyleAccess(false)
@@ -91,6 +92,7 @@ public void testExplicitPropertyMappings()
                 .put("hive.s3.aws-access-key", "abc123")
                 .put("hive.s3.aws-secret-key", "secret")
                 .put("hive.s3.endpoint", "endpoint.example.com")
+                .put("hive.s3.region", "eu-central-1")
                 .put("hive.s3.signer-type", "S3SignerType")
                 .put("hive.s3.signer-class", "com.amazonaws.services.s3.internal.AWSS3V4Signer")
                 .put("hive.s3.path-style-access", "true")
@@ -135,6 +137,7 @@ public void testExplicitPropertyMappings()
                 .setS3AwsAccessKey("abc123")
                 .setS3AwsSecretKey("secret")
                 .setS3Endpoint("endpoint.example.com")
+                .setS3Region("eu-central-1")
                 .setS3SignerType(TrinoS3SignerType.S3SignerType)
                 .setS3SignerClass("com.amazonaws.services.s3.internal.AWSS3V4Signer")
                 .setS3PathStyleAccess(true)
diff --git a/plugin/trino-hive/src/test/java/io/trino/plugin/hive/s3/TestTrinoS3FileSystem.java b/plugin/trino-hive/src/test/java/io/trino/plugin/hive/s3/TestTrinoS3FileSystem.java
index dc080a87bf1b..5c420ee34dbb 100644
--- a/plugin/trino-hive/src/test/java/io/trino/plugin/hive/s3/TestTrinoS3FileSystem.java
+++ b/plugin/trino-hive/src/test/java/io/trino/plugin/hive/s3/TestTrinoS3FileSystem.java
@@ -87,6 +87,7 @@
 import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_MAX_RETRY_TIME;
 import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_PATH_STYLE_ACCESS;
 import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_PIN_CLIENT_TO_CURRENT_REGION;
+import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_REGION;
 import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_SECRET_KEY;
 import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_SESSION_TOKEN;
 import static io.trino.plugin.hive.s3.TrinoS3FileSystem.S3_SKIP_GLACIER_OBJECTS;
@@ -171,6 +172,19 @@ public void testEndpointWithPinToCurrentRegionConfiguration()
         }
     }
 
+    @Test
+    public void testEndpointWithExplicitRegionConfiguration()
+            throws Exception
+    {
+        Configuration config = newEmptyConfiguration();
+        config.set(S3_ENDPOINT, "test.example.endpoint.com");
+        config.set(S3_REGION, "region1");
+        try (TrinoS3FileSystem fs = new TrinoS3FileSystem()) {
+            fs.initialize(new URI("s3a://test-bucket/"), config);
+            assertThat(((AmazonS3Client) fs.getS3Client()).getSignerRegionOverride()).isEqualTo("region1");
+        }
+    }
+
     @Test
     public void testAssumeRoleDefaultCredentials()
             throws Exception