diff --git a/src/transform/loop_vectorize.cc b/src/transform/loop_vectorize.cc
index e8a18b004..17c9e1f66 100644
--- a/src/transform/loop_vectorize.cc
+++ b/src/transform/loop_vectorize.cc
@@ -290,6 +290,24 @@ bool IndiceCanVectorize(const PrimExpr &expr, Var var,
   if (!analyzer->CanProveEqual(FloorMod(iter_var_size, target_size_for_iter),
                                0))
     return false;
+
+  // Check if expr is invariant within vector boundaries
+  // We're trying to prove the access expression A[f(var)] depends only on
+  // floor(var/vecsize), not on var%vecsize
+  // Mathematically:
+  // \forall var, f(floor(var/vecsize)*vecsize + var%vecsize) ==
+  // f(floor(var/vecsize)*vecsize + 0)
+  // Example: for i in T.vectorized(8):
+  //     A[i] = B[i] * C[i//4]
+  // if vecsize=4, f(i)=i//4 depends only on i//4
+  // Therefore A[i] = B[i] * C[i//4] can be vectorized with vecsize=4
+  PrimExpr var_aligned =
+      floordiv(var, target_vectorized_size) * target_vectorized_size;
+  PrimExpr expr_aligned = Substitute(expr, {{var, var_aligned}});
+  if (analyzer->CanProveEqual(expr, expr_aligned)) {
+    return true;
+  }
+
   auto simplified_expr = analyzer->Simplify(Substitute(expr, {{var, zero}}));
   // The base offset must be divisible
   if (!analyzer->CanProveEqual(FloorMod(simplified_expr, target_size_for_expr),
diff --git a/testing/python/language/test_tilelang_language_vectorize.py b/testing/python/language/test_tilelang_language_vectorize.py
index cee8b5a63..bc2d31446 100644
--- a/testing/python/language/test_tilelang_language_vectorize.py
+++ b/testing/python/language/test_tilelang_language_vectorize.py
@@ -5,7 +5,6 @@
 
 @tilelang.jit(pass_configs={tilelang.PassConfigKey.TL_DISABLE_VECTORIZE_256: True})
 def vectorize_test(N, M, stride_A, stride_B):
-    assert N % 128 == 0 and M % 128 == 0
 
     @T.prim_func
     def main(
@@ -23,6 +22,7 @@ def main(
 
 
 def run_vectorize(N, M, stride_A, stride_B):
+    assert N % 128 == 0 and M % 128 == 0
     assert stride_A >= N and stride_B >= N
 
     jit_kernel = vectorize_test(N, M, stride_A, stride_B)
@@ -59,5 +59,62 @@ def test_vectorize():
     run_vectorize(N, M, N + 8, N + 16)
 
 
+@tilelang.jit(pass_configs={tilelang.PassConfigKey.TL_DISABLE_VECTORIZE_256: True})
+def vectorize_test_invariant_index(N, M, K):
+
+    @T.prim_func
+    def main(
+            A: T.Tensor[(N, M), "float32"],  # noqa: F821
+            B: T.Tensor[(N, M), "float32"],  # noqa: F821
+            C: T.Tensor[(N, M // K), "float32"],  # noqa: F821
+    ):
+        with T.Kernel(N // 128, threads=128) as (bx):
+            tx = T.get_thread_binding(0)
+            row = bx * 128 + tx
+
+            for col in T.vectorized(M):
+                B[row, col] = A[row, col] * C[row, col // K]
+
+    return main
+
+
+def run_vectorize_invariant_index(N, M, K):
+    assert N % 128 == 0 and M % K == 0
+
+    jit_kernel = vectorize_test_invariant_index(N, M, K)
+
+    a = torch.randn(N, M, device="cuda", dtype=torch.float32)
+    b = torch.zeros(N, M, device="cuda", dtype=torch.float32)
+    c = torch.randn(N, M // K, device="cuda", dtype=torch.float32)
+
+    jit_kernel(a, b, c)
+
+    indices = torch.arange(a.size(1)) // K
+    ret = a * c[:, indices]
+    torch.testing.assert_close(b, ret, atol=1e-8, rtol=1e-8)
+
+    code = jit_kernel.get_kernel_source()
+
+    vectorize_size = 1
+    while vectorize_size <= 2 and K % (vectorize_size * 2) == 0:
+        vectorize_size *= 2
+
+    if vectorize_size == 4:
+        assert "float4" in code
+    elif vectorize_size == 2:
+        assert "float2" in code
+
+
+def test_vectorize_invariant_index():
+    N, M = 512, 256
+
+    run_vectorize_invariant_index(N, M, 2)
+    run_vectorize_invariant_index(N, M, 4)
+    run_vectorize_invariant_index(N, M * 3, 6)
+    run_vectorize_invariant_index(N, M, 8)
+    run_vectorize_invariant_index(N, M * 3, 12)
+    run_vectorize_invariant_index(N, M * 7, 14)
+
+
 if __name__ == "__main__":
     tilelang.testing.main()