diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 97fb371ebd..08995c057c 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -15,7 +15,7 @@ jobs:
       # Run regular TUF tests on each OS/Python combination, plus special tests
       # (sslib master) and linters on Linux/Python3.x only.
       matrix:
-        python-version: [3.6, 3.7, 3.8, 3.9]
+        python-version: ['3.6', '3.7', '3.8', '3.9', '3.10']
         os: [ubuntu-latest, macos-latest, windows-latest]
         toxenv: [py]
         include:
diff --git a/setup.py b/setup.py
index 3fb92ce661..01440920a1 100755
--- a/setup.py
+++ b/setup.py
@@ -101,6 +101,7 @@
     'Programming Language :: Python :: 3.7',
     'Programming Language :: Python :: 3.8',
     'Programming Language :: Python :: 3.9',
+    'Programming Language :: Python :: 3.10',
     'Programming Language :: Python :: Implementation :: CPython',
     'Topic :: Security',
     'Topic :: Software Development'
diff --git a/tox.ini b/tox.ini
index 48475539be..d356959cf3 100644
--- a/tox.ini
+++ b/tox.ini
@@ -4,7 +4,7 @@
 # and then run "tox" from this directory.
 
 [tox]
-envlist = lint,py{36,37,38,39}
+envlist = lint,py{36,37,38,39,3.10}
 skipsdist = true
 
 [testenv]