diff --git a/.changes/nsis-cleanup-installdir-reg.md b/.changes/nsis-cleanup-installdir-reg.md
new file mode 100644
index 000000000000..4e8f7967d6c9
--- /dev/null
+++ b/.changes/nsis-cleanup-installdir-reg.md
@@ -0,0 +1,5 @@
+---
+'tauri-bundler': 'patch:bug'
+---
+
+Clean up `Software\${MANUFACTURER}\${PRODUCTNAME}` registry key in the NSIS uninstaller if "Delete application data" option is checked when uninstalling. 
diff --git a/crates/tauri-bundler/src/bundle/windows/nsis/installer.nsi b/crates/tauri-bundler/src/bundle/windows/nsis/installer.nsi
index 5270de2ad04c..8ed4adc0b58f 100644
--- a/crates/tauri-bundler/src/bundle/windows/nsis/installer.nsi
+++ b/crates/tauri-bundler/src/bundle/windows/nsis/installer.nsi
@@ -56,7 +56,8 @@ ${StrLoc}
 !define WEBVIEW2INSTALLERPATH "{{webview2_installer_path}}"
 !define MINIMUMWEBVIEW2VERSION "{{minimum_webview2_version}}"
 !define UNINSTKEY "Software\Microsoft\Windows\CurrentVersion\Uninstall\${PRODUCTNAME}"
-!define MANUPRODUCTKEY "Software\${MANUFACTURER}\${PRODUCTNAME}"
+!define MANUKEY "Software\${MANUFACTURER}"
+!define MANUPRODUCTKEY "${MANUKEY}\${PRODUCTNAME}"
 !define UNINSTALLERSIGNCOMMAND "{{uninstaller_sign_cmd}}"
 !define ESTIMATEDSIZE "{{estimated_size}}"
 !define STARTMENUFOLDER "{{start_menu_folder}}"
@@ -834,12 +835,19 @@ Section Uninstall
     DeleteRegKey HKCU "${UNINSTKEY}"
   !endif
 
-  DeleteRegValue HKCU "${MANUPRODUCTKEY}" "Installer Language"
-
   ; Delete app data if the checkbox is selected
   ; and if not updating
   ${If} $DeleteAppDataCheckboxState = 1
   ${AndIf} $UpdateMode <> 1
+    ; Clear the install location $INSTDIR from registry
+    DeleteRegKey SHCTX "${MANUPRODUCTKEY}"
+    DeleteRegKey /ifempty SHCTX "${MANUKEY}"
+
+    ; Clear the install language from registry
+    DeleteRegValue HKCU "${MANUPRODUCTKEY}" "Installer Language"
+    DeleteRegKey /ifempty HKCU "${MANUPRODUCTKEY}"
+    DeleteRegKey /ifempty HKCU "${MANUKEY}"
+
     SetShellVarContext current
     RmDir /r "$APPDATA\${BUNDLEID}"
     RmDir /r "$LOCALAPPDATA\${BUNDLEID}"