diff --git a/deps/v8/src/execution/isolate.cc b/deps/v8/src/execution/isolate.cc
index c9c6225eb8fd8b..5c21b0982e9315 100644
--- a/deps/v8/src/execution/isolate.cc
+++ b/deps/v8/src/execution/isolate.cc
@@ -3431,15 +3431,15 @@ bool Isolate::Init(ReadOnlyDeserializer* read_only_deserializer,
 
     setup_delegate_->SetupBuiltins(this);
 
-#if !defined(V8_TARGET_ARCH_ARM) && !defined(V8_TARGET_ARCH_S390X)
+#ifndef V8_TARGET_ARCH_ARM
     // Store the interpreter entry trampoline on the root list. It is used as a
     // template for further copies that may later be created to help profile
     // interpreted code.
-    // We currently cannot do this on above architectures due to
-    // RELATIVE_CODE_TARGETs assuming that all possible Code targets may be
-    // addressed with an int24 offset, effectively limiting code space size to
-    // 32MB. We can guarantee this at mksnapshot-time, but not at runtime. See
-    // also: https://crbug.com/v8/8713.
+    // We currently cannot do this on arm due to RELATIVE_CODE_TARGETs
+    // assuming that all possible Code targets may be addressed with an int24
+    // offset, effectively limiting code space size to 32MB. We can guarantee
+    // this at mksnapshot-time, but not at runtime.
+    // See also: https://crbug.com/v8/8713.
     heap_.SetInterpreterEntryTrampolineForProfiling(
         heap_.builtin(Builtins::kInterpreterEntryTrampoline));
 #endif
@@ -3514,11 +3514,11 @@ bool Isolate::Init(ReadOnlyDeserializer* read_only_deserializer,
   }
 #endif  // DEBUG
 
-#if !defined(V8_TARGET_ARCH_ARM) && !defined(V8_TARGET_ARCH_S390X)
+#ifndef V8_TARGET_ARCH_ARM
   // The IET for profiling should always be a full on-heap Code object.
   DCHECK(!Code::cast(heap_.interpreter_entry_trampoline_for_profiling())
               .is_off_heap_trampoline());
-#endif  // !V8_TARGET_ARCH_ARM && !V8_TARGET_ARCH_S390X
+#endif  // V8_TARGET_ARCH_ARM
 
   if (FLAG_print_builtin_code) builtins()->PrintBuiltinCode();
   if (FLAG_print_builtin_size) builtins()->PrintBuiltinSize();
diff --git a/deps/v8/src/flags/flag-definitions.h b/deps/v8/src/flags/flag-definitions.h
index c3f360cdf0d850..2384cf4a28f19c 100644
--- a/deps/v8/src/flags/flag-definitions.h
+++ b/deps/v8/src/flags/flag-definitions.h
@@ -1625,8 +1625,8 @@ DEFINE_BOOL(vtune_prof_annotate_wasm, false,
 
 DEFINE_BOOL(win64_unwinding_info, true, "Enable unwinding info for Windows/x64")
 
-#if defined(V8_TARGET_ARCH_ARM) || defined(V8_TARGET_ARCH_S390X)
-// Unsupported on above architectures. See https://crbug.com/v8/8713.
+#ifdef V8_TARGET_ARCH_ARM
+// Unsupported on arm. See https://crbug.com/v8/8713.
 DEFINE_BOOL_READONLY(
     interpreted_frames_native_stack, false,
     "Show interpreted frames on the native stack (useful for external "
diff --git a/deps/v8/src/snapshot/code-serializer.cc b/deps/v8/src/snapshot/code-serializer.cc
index d155313872f21e..b6e2ec65e31c89 100644
--- a/deps/v8/src/snapshot/code-serializer.cc
+++ b/deps/v8/src/snapshot/code-serializer.cc
@@ -190,12 +190,12 @@ void CodeSerializer::SerializeObject(HeapObject obj) {
   // bytecode array stored within the InterpreterData, which is the important
   // information. On deserialization we'll create our code objects again, if
   // --interpreted-frames-native-stack is on. See v8:9122 for more context
-#if !defined(V8_TARGET_ARCH_ARM) && !defined(V8_TARGET_ARCH_S390X)
+#ifndef V8_TARGET_ARCH_ARM
   if (V8_UNLIKELY(FLAG_interpreted_frames_native_stack) &&
       obj.IsInterpreterData()) {
     obj = InterpreterData::cast(obj).bytecode_array();
   }
-#endif  // !V8_TARGET_ARCH_ARM && !V8_TARGET_ARCH_S390X
+#endif  // V8_TARGET_ARCH_ARM
 
   // Past this point we should not see any (context-specific) maps anymore.
   CHECK(!obj.IsMap());
@@ -215,7 +215,7 @@ void CodeSerializer::SerializeGeneric(HeapObject heap_object) {
   serializer.Serialize();
 }
 
-#if !defined(V8_TARGET_ARCH_ARM) && !defined(V8_TARGET_ARCH_S390X)
+#ifndef V8_TARGET_ARCH_ARM
 // NOTE(mmarchini): when FLAG_interpreted_frames_native_stack is on, we want to
 // create duplicates of InterpreterEntryTrampoline for the deserialized
 // functions, otherwise we'll call the builtin IET for those functions (which
@@ -255,7 +255,7 @@ void CreateInterpreterDataForDeserializedCode(Isolate* isolate,
                             column_num));
   }
 }
-#endif  // !V8_TARGET_ARCH_ARM && !V8_TARGET_ARCH_S390X
+#endif  // V8_TARGET_ARCH_ARM
 
 MaybeHandle<SharedFunctionInfo> CodeSerializer::Deserialize(
     Isolate* isolate, ScriptData* cached_data, Handle<String> source,
@@ -301,11 +301,11 @@ MaybeHandle<SharedFunctionInfo> CodeSerializer::Deserialize(
       isolate->is_profiling() ||
       isolate->code_event_dispatcher()->IsListeningToCodeEvents();
 
-#if !defined(V8_TARGET_ARCH_ARM) && !defined(V8_TARGET_ARCH_S390X)
+#ifndef V8_TARGET_ARCH_ARM
   if (V8_UNLIKELY(FLAG_interpreted_frames_native_stack))
     CreateInterpreterDataForDeserializedCode(isolate, result,
                                              log_code_creation);
-#endif  // !V8_TARGET_ARCH_ARM && !V8_TARGET_ARCH_S390X
+#endif  // V8_TARGET_ARCH_ARM
 
   bool needs_source_positions = isolate->NeedsSourcePositionsForProfiling();
 
diff --git a/deps/v8/test/cctest/interpreter/test-interpreter.cc b/deps/v8/test/cctest/interpreter/test-interpreter.cc
index 33daf581c7ce17..bd9edb127b28b6 100644
--- a/deps/v8/test/cctest/interpreter/test-interpreter.cc
+++ b/deps/v8/test/cctest/interpreter/test-interpreter.cc
@@ -5029,7 +5029,7 @@ TEST(InterpreterGenerators) {
   }
 }
 
-#if !defined(V8_TARGET_ARCH_ARM) && !defined(V8_TARGET_ARCH_S390X)
+#ifndef V8_TARGET_ARCH_ARM
 TEST(InterpreterWithNativeStack) {
   i::FLAG_interpreted_frames_native_stack = true;
 
@@ -5051,7 +5051,7 @@ TEST(InterpreterWithNativeStack) {
   CHECK(code.is_interpreter_trampoline_builtin());
   CHECK_NE(code.address(), interpreter_entry_trampoline->address());
 }
-#endif  // !V8_TARGET_ARCH_ARM && !V8_TARGET_ARCH_S390X
+#endif  // V8_TARGET_ARCH_ARM
 
 TEST(InterpreterGetBytecodeHandler) {
   HandleAndZoneScope handles;
diff --git a/deps/v8/test/cctest/test-log.cc b/deps/v8/test/cctest/test-log.cc
index 5531b7ec955ade..254fed7db2a115 100644
--- a/deps/v8/test/cctest/test-log.cc
+++ b/deps/v8/test/cctest/test-log.cc
@@ -565,7 +565,7 @@ UNINITIALIZED_TEST(LogAll) {
   isolate->Dispose();
 }
 
-#if !defined(V8_TARGET_ARCH_ARM) && !defined(V8_TARGET_ARCH_S390X)
+#ifndef V8_TARGET_ARCH_ARM
 UNINITIALIZED_TEST(LogInterpretedFramesNativeStack) {
   SETUP_FLAGS();
   i::FLAG_interpreted_frames_native_stack = true;
@@ -650,7 +650,7 @@ UNINITIALIZED_TEST(LogInterpretedFramesNativeStackWithSerialization) {
   } while (!has_cache);
   delete cache;
 }
-#endif  // !V8_TARGET_ARCH_ARM && !V8_TARGET_ARCH_S390X
+#endif  // V8_TARGET_ARCH_ARM
 
 UNINITIALIZED_TEST(ExternalCodeEventListener) {
   i::FLAG_log = false;
@@ -753,7 +753,7 @@ UNINITIALIZED_TEST(ExternalCodeEventListenerInnerFunctions) {
   isolate2->Dispose();
 }
 
-#if !defined(V8_TARGET_ARCH_ARM) && !defined(V8_TARGET_ARCH_S390X)
+#ifndef V8_TARGET_ARCH_ARM
 UNINITIALIZED_TEST(ExternalCodeEventListenerWithInterpretedFramesNativeStack) {
   i::FLAG_log = false;
   i::FLAG_prof = false;
@@ -803,7 +803,7 @@ UNINITIALIZED_TEST(ExternalCodeEventListenerWithInterpretedFramesNativeStack) {
   }
   isolate->Dispose();
 }
-#endif  // !V8_TARGET_ARCH_ARM && !V8_TARGET_ARCH_S390X
+#endif  // V8_TARGET_ARCH_ARM
 
 UNINITIALIZED_TEST(TraceMaps) {
   SETUP_FLAGS();
diff --git a/deps/v8/test/cctest/test-serialize.cc b/deps/v8/test/cctest/test-serialize.cc
index b7590cd0217cff..d92d34faef4c75 100644
--- a/deps/v8/test/cctest/test-serialize.cc
+++ b/deps/v8/test/cctest/test-serialize.cc
@@ -1672,7 +1672,7 @@ void TestCodeSerializerOnePlusOneImpl(bool verify_builtins_count = true) {
 TEST(CodeSerializerOnePlusOne) { TestCodeSerializerOnePlusOneImpl(); }
 
 // See bug v8:9122
-#if !defined(V8_TARGET_ARCH_ARM) && !defined(V8_TARGET_ARCH_S390X)
+#ifndef V8_TARGET_ARCH_ARM
 TEST(CodeSerializerOnePlusOneWithInterpretedFramesNativeStack) {
   FLAG_interpreted_frames_native_stack = true;
   // We pass false because this test will create IET copies (which are