diff --git a/CHANGELOG.md b/CHANGELOG.md
index 1abf149f49b6..7e31c9aa654f 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -22,6 +22,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 - Fix incorrect angle in `-bg-conic-*` utilities ([#17174](https://github.com/tailwindlabs/tailwindcss/pull/17174))
 - Fix `border-[12px_4px]` being interpreted as a `border-color` instead of a `border-width` ([#17248](https://github.com/tailwindlabs/tailwindcss/pull/17248))
+- Use the `oklab(…)` function when applying opacity to `currentColor` to work around a crash in Safari 16.4 and 16.5 ([#17247](https://github.com/tailwindlabs/tailwindcss/pull/17247))
 
 ## [4.0.14] - 2025-03-13
 
diff --git a/integrations/vite/astro.test.ts b/integrations/vite/astro.test.ts
index 81db3e82c6d5..43406624c316 100644
--- a/integrations/vite/astro.test.ts
+++ b/integrations/vite/astro.test.ts
@@ -19,7 +19,10 @@ test(
         import { defineConfig } from 'astro/config'
 
         // https://astro.build/config
-        export default defineConfig({ vite: { plugins: [tailwindcss()] } })
+        export default defineConfig({
+          vite: { plugins: [tailwindcss()] },
+          build: { inlineStylesheets: 'never' },
+        })
       `,
       'src/pages/index.astro': html`
        <div class="underline">Hello, world!</div>
@@ -90,8 +93,13 @@ test(
         import { defineConfig } from 'astro/config'
 
         // https://astro.build/config
-        export default defineConfig({ vite: { plugins: [tailwindcss()] }, integrations: [react()] })
+        export default defineConfig({
+          vite: { plugins: [tailwindcss()] },
+          integrations: [react()],
+          build: { inlineStylesheets: 'never' },
+        })
       `,
+      // prettier-ignore
       'src/pages/index.astro': html`
         ---
         import ClientOnly from './client-only';
diff --git a/packages/@tailwindcss-postcss/src/__snapshots__/index.test.ts.snap b/packages/@tailwindcss-postcss/src/__snapshots__/index.test.ts.snap
index dbf73d755e12..3b61a8be89f9 100644
--- a/packages/@tailwindcss-postcss/src/__snapshots__/index.test.ts.snap
+++ b/packages/@tailwindcss-postcss/src/__snapshots__/index.test.ts.snap
@@ -169,7 +169,7 @@ exports[`\`@import 'tailwindcss'\` is replaced with the generated CSS 1`] = `
 
   ::placeholder {
     opacity: 1;
-    color: color-mix(in oklab, currentColor 50%, transparent);
+    color: oklab(from currentColor l a b / 50%);
   }
 
   textarea {
diff --git a/packages/tailwindcss/preflight.css b/packages/tailwindcss/preflight.css
index 632d8aa1f246..f3163581236f 100644
--- a/packages/tailwindcss/preflight.css
+++ b/packages/tailwindcss/preflight.css
@@ -285,12 +285,12 @@ textarea,
 
 /*
   1. Reset the default placeholder opacity in Firefox. (https://github.com/tailwindlabs/tailwindcss/issues/3300)
-  2. Set the default placeholder color to a semi-transparent version of the current text color.
+  2. Set the default placeholder color to a semi-transparent version of the current text color. We use the `oklab(…)` function to work around an issue in Safari 16.4 and 16.5. (https://github.com/tailwindlabs/tailwindcss/issues/17194)
 */
 
 ::placeholder {
   opacity: 1; /* 1 */
-  color: color-mix(in oklab, currentColor 50%, transparent); /* 2 */
+  color: oklab(from currentColor l a b / 50%); /* 2 */
 }
 
 /*
diff --git a/packages/tailwindcss/src/__snapshots__/utilities.test.ts.snap b/packages/tailwindcss/src/__snapshots__/utilities.test.ts.snap
index 5f1c2fea3f54..a33a5371acff 100644
--- a/packages/tailwindcss/src/__snapshots__/utilities.test.ts.snap
+++ b/packages/tailwindcss/src/__snapshots__/utilities.test.ts.snap
@@ -104,7 +104,7 @@ exports[`border-* 1`] = `
 }
 
 .border-current\\/50 {
-  border-color: color-mix(in oklab, currentColor 50%, transparent);
+  border-color: oklab(from currentColor l a b / 50%);
 }
 
 .border-inherit {
@@ -246,7 +246,7 @@ exports[`border-b-* 1`] = `
 }
 
 .border-b-current\\/50 {
-  border-bottom-color: color-mix(in oklab, currentColor 50%, transparent);
+  border-bottom-color: oklab(from currentColor l a b / 50%);
 }
 
 .border-b-inherit {
@@ -388,7 +388,7 @@ exports[`border-e-* 1`] = `
 }
 
 .border-e-current\\/50 {
-  border-inline-end-color: color-mix(in oklab, currentColor 50%, transparent);
+  border-inline-end-color: oklab(from currentColor l a b / 50%);
 }
 
 .border-e-inherit {
@@ -530,7 +530,7 @@ exports[`border-l-* 1`] = `
 }
 
 .border-l-current\\/50 {
-  border-left-color: color-mix(in oklab, currentColor 50%, transparent);
+  border-left-color: oklab(from currentColor l a b / 50%);
 }
 
 .border-l-inherit {
@@ -672,7 +672,7 @@ exports[`border-r-* 1`] = `
 }
 
 .border-r-current\\/50 {
-  border-right-color: color-mix(in oklab, currentColor 50%, transparent);
+  border-right-color: oklab(from currentColor l a b / 50%);
 }
 
 .border-r-inherit {
@@ -814,7 +814,7 @@ exports[`border-s-* 1`] = `
 }
 
 .border-s-current\\/50 {
-  border-inline-start-color: color-mix(in oklab, currentColor 50%, transparent);
+  border-inline-start-color: oklab(from currentColor l a b / 50%);
 }
 
 .border-s-inherit {
@@ -956,7 +956,7 @@ exports[`border-t-* 1`] = `
 }
 
 .border-t-current\\/50 {
-  border-top-color: color-mix(in oklab, currentColor 50%, transparent);
+  border-top-color: oklab(from currentColor l a b / 50%);
 }
 
 .border-t-inherit {
@@ -1098,7 +1098,7 @@ exports[`border-x-* 1`] = `
 }
 
 .border-x-current\\/50 {
-  border-inline-color: color-mix(in oklab, currentColor 50%, transparent);
+  border-inline-color: oklab(from currentColor l a b / 50%);
 }
 
 .border-x-inherit {
@@ -1240,7 +1240,7 @@ exports[`border-y-* 1`] = `
 }
 
 .border-y-current\\/50 {
-  border-block-color: color-mix(in oklab, currentColor 50%, transparent);
+  border-block-color: oklab(from currentColor l a b / 50%);
 }
 
 .border-y-inherit {
diff --git a/packages/tailwindcss/src/compat/plugin-api.test.ts b/packages/tailwindcss/src/compat/plugin-api.test.ts
index b786f2311e28..d552b805dd8e 100644
--- a/packages/tailwindcss/src/compat/plugin-api.test.ts
+++ b/packages/tailwindcss/src/compat/plugin-api.test.ts
@@ -3860,7 +3860,7 @@ describe('matchUtilities()', () => {
       }
 
       .scrollbar-current\\/45 {
-        scrollbar-color: color-mix(in oklab, currentColor 45%, transparent);
+        scrollbar-color: oklab(from currentColor l a b / 45%);
       }"
     `)
   })
diff --git a/packages/tailwindcss/src/utilities.test.ts b/packages/tailwindcss/src/utilities.test.ts
index d19d9aa111d8..9c732878a2a0 100644
--- a/packages/tailwindcss/src/utilities.test.ts
+++ b/packages/tailwindcss/src/utilities.test.ts
@@ -7984,7 +7984,7 @@ test('accent', async () => {
     }
 
     .accent-current\\/50, .accent-current\\/\\[0\\.5\\], .accent-current\\/\\[50\\%\\] {
-      accent-color: color-mix(in oklab, currentColor 50%, transparent);
+      accent-color: oklab(from currentColor l a b / 50%);
     }
 
     .accent-inherit {
@@ -8099,7 +8099,7 @@ test('caret', async () => {
     }
 
     .caret-current\\/50, .caret-current\\/\\[0\\.5\\], .caret-current\\/\\[50\\%\\] {
-      caret-color: color-mix(in oklab, currentColor 50%, transparent);
+      caret-color: oklab(from currentColor l a b / 50%);
     }
 
     .caret-inherit {
@@ -8212,7 +8212,7 @@ test('divide-color', async () => {
     }
 
     :where(.divide-current\\/50 > :not(:last-child)), :where(.divide-current\\/\\[0\\.5\\] > :not(:last-child)), :where(.divide-current\\/\\[50\\%\\] > :not(:last-child)) {
-      border-color: color-mix(in oklab, currentColor 50%, transparent);
+      border-color: oklab(from currentColor l a b / 50%);
     }
 
     :where(.divide-inherit > :not(:last-child)) {
@@ -10144,11 +10144,11 @@ test('bg', async () => {
     }
 
     .bg-current\\/50, .bg-current\\/\\[0\\.5\\], .bg-current\\/\\[50\\%\\] {
-      background-color: color-mix(in oklab, currentColor 50%, transparent);
+      background-color: oklab(from currentColor l a b / 50%);
     }
 
     .bg-current\\/\\[var\\(--bg-opacity\\)\\] {
-      background-color: color-mix(in oklab, currentColor var(--bg-opacity), transparent);
+      background-color: oklab(from currentColor l a b / var(--bg-opacity));
     }
 
     .bg-inherit {
@@ -10666,11 +10666,11 @@ test('bg', async () => {
     ),
   ).toMatchInlineSnapshot(`
     ".bg-current\\/custom {
-      background-color: color-mix(in oklab, currentColor var(--opacity-custom, var(--custom-opacity)), transparent);
+      background-color: oklab(from currentColor l a b / var(--opacity-custom, var(--custom-opacity)));
     }
 
     .bg-current\\/half {
-      background-color: color-mix(in oklab, currentColor var(--opacity-half, .5), transparent);
+      background-color: oklab(from currentColor l a b / var(--opacity-half, .5));
     }
 
     .\\[color\\:red\\]\\/half {
@@ -10764,7 +10764,7 @@ test('from', async () => {
     }
 
     .from-current\\/50, .from-current\\/\\[0\\.5\\], .from-current\\/\\[50\\%\\] {
-      --tw-gradient-from: color-mix(in oklab, currentColor 50%, transparent);
+      --tw-gradient-from: oklab(from currentColor l a b / 50%);
       --tw-gradient-stops: var(--tw-gradient-via-stops, var(--tw-gradient-position), var(--tw-gradient-from) var(--tw-gradient-from-position), var(--tw-gradient-to) var(--tw-gradient-to-position));
     }
 
@@ -10990,7 +10990,7 @@ test('via', async () => {
     }
 
     .via-current\\/50, .via-current\\/\\[0\\.5\\], .via-current\\/\\[50\\%\\] {
-      --tw-gradient-via: color-mix(in oklab, currentColor 50%, transparent);
+      --tw-gradient-via: oklab(from currentColor l a b / 50%);
       --tw-gradient-via-stops: var(--tw-gradient-position), var(--tw-gradient-from) var(--tw-gradient-from-position), var(--tw-gradient-via) var(--tw-gradient-via-position), var(--tw-gradient-to) var(--tw-gradient-to-position);
       --tw-gradient-stops: var(--tw-gradient-via-stops);
     }
@@ -11212,7 +11212,7 @@ test('to', async () => {
     }
 
     .to-current\\/50, .to-current\\/\\[0\\.5\\], .to-current\\/\\[50\\%\\] {
-      --tw-gradient-to: color-mix(in oklab, currentColor 50%, transparent);
+      --tw-gradient-to: oklab(from currentColor l a b / 50%);
       --tw-gradient-stops: var(--tw-gradient-via-stops, var(--tw-gradient-position), var(--tw-gradient-from) var(--tw-gradient-from-position), var(--tw-gradient-to) var(--tw-gradient-to-position));
     }
 
@@ -11739,7 +11739,7 @@ test('fill', async () => {
     }
 
     .fill-current\\/50, .fill-current\\/\\[0\\.5\\], .fill-current\\/\\[50\\%\\] {
-      fill: color-mix(in oklab, currentColor 50%, transparent);
+      fill: oklab(from currentColor l a b / 50%);
     }
 
     .fill-inherit {
@@ -11876,7 +11876,7 @@ test('stroke', async () => {
     }
 
     .stroke-current\\/50, .stroke-current\\/\\[0\\.5\\], .stroke-current\\/\\[50\\%\\] {
-      stroke: color-mix(in oklab, currentColor 50%, transparent);
+      stroke: oklab(from currentColor l a b / 50%);
     }
 
     .stroke-inherit {
@@ -12852,7 +12852,7 @@ test('placeholder', async () => {
     }
 
     .placeholder-current\\/50::placeholder, .placeholder-current\\/\\[0\\.5\\]::placeholder, .placeholder-current\\/\\[50\\%\\]::placeholder {
-      color: color-mix(in oklab, currentColor 50%, transparent);
+      color: oklab(from currentColor l a b / 50%);
     }
 
     .placeholder-inherit::placeholder {
@@ -13001,9 +13001,9 @@ test('decoration', async () => {
     }
 
     .decoration-current\\/50, .decoration-current\\/\\[0\\.5\\], .decoration-current\\/\\[50\\%\\] {
-      -webkit-text-decoration-color: color-mix(in oklab, currentColor 50%, transparent);
-      -webkit-text-decoration-color: color-mix(in oklab, currentColor 50%, transparent);
-      text-decoration-color: color-mix(in oklab, currentColor 50%, transparent);
+      -webkit-text-decoration-color: oklab(from currentColor l a b / 50%);
+      -webkit-text-decoration-color: oklab(from currentColor l a b / 50%);
+      text-decoration-color: oklab(from currentColor l a b / 50%);
     }
 
     .decoration-inherit {
@@ -14706,7 +14706,7 @@ test('outline', async () => {
     }
 
     .outline-current\\/50, .outline-current\\/\\[0\\.5\\], .outline-current\\/\\[50\\%\\] {
-      outline-color: color-mix(in oklab, currentColor 50%, transparent);
+      outline-color: oklab(from currentColor l a b / 50%);
     }
 
     .outline-inherit {
@@ -15156,7 +15156,7 @@ test('text', async () => {
     }
 
     .text-current\\/50, .text-current\\/\\[0\\.5\\], .text-current\\/\\[50\\%\\] {
-      color: color-mix(in oklab, currentColor 50%, transparent);
+      color: oklab(from currentColor l a b / 50%);
     }
 
     .text-inherit {
@@ -15325,7 +15325,7 @@ test('shadow', async () => {
     }
 
     .shadow-current\\/50, .shadow-current\\/\\[0\\.5\\], .shadow-current\\/\\[50\\%\\] {
-      --tw-shadow-color: color-mix(in oklab, currentColor 50%, transparent);
+      --tw-shadow-color: oklab(from currentColor l a b / 50%);
     }
 
     .shadow-inherit {
@@ -15547,7 +15547,7 @@ test('inset-shadow', async () => {
     }
 
     .inset-shadow-current\\/50, .inset-shadow-current\\/\\[0\\.5\\], .inset-shadow-current\\/\\[50\\%\\] {
-      --tw-inset-shadow-color: color-mix(in oklab, currentColor 50%, transparent);
+      --tw-inset-shadow-color: oklab(from currentColor l a b / 50%);
     }
 
     .inset-shadow-inherit {
@@ -15785,7 +15785,7 @@ test('ring', async () => {
     }
 
     .ring-current\\/50, .ring-current\\/\\[0\\.5\\], .ring-current\\/\\[50\\%\\] {
-      --tw-ring-color: color-mix(in oklab, currentColor 50%, transparent);
+      --tw-ring-color: oklab(from currentColor l a b / 50%);
     }
 
     .ring-inherit {
@@ -16124,7 +16124,7 @@ test('inset-ring', async () => {
     }
 
     .inset-ring-current\\/50, .inset-ring-current\\/\\[0\\.5\\], .inset-ring-current\\/\\[50\\%\\] {
-      --tw-inset-ring-color: color-mix(in oklab, currentColor 50%, transparent);
+      --tw-inset-ring-color: oklab(from currentColor l a b / 50%);
     }
 
     .inset-ring-inherit {
@@ -16368,7 +16368,7 @@ test('ring-offset', async () => {
     }
 
     .ring-offset-current\\/50, .ring-offset-current\\/\\[0\\.5\\], .ring-offset-current\\/\\[50\\%\\] {
-      --tw-ring-offset-color: color-mix(in oklab, currentColor 50%, transparent);
+      --tw-ring-offset-color: oklab(from currentColor l a b / 50%);
     }
 
     .ring-offset-inherit {
diff --git a/packages/tailwindcss/src/utilities.ts b/packages/tailwindcss/src/utilities.ts
index 31acd41df2a4..2b5782993eaa 100644
--- a/packages/tailwindcss/src/utilities.ts
+++ b/packages/tailwindcss/src/utilities.ts
@@ -136,6 +136,13 @@ export function withAlpha(value: string, alpha: string): string {
     alpha = `${alphaAsNumber * 100}%`
   }
 
+  // Use the `oklab(…)` function when applying alpha to `currentColor` to work
+  // around a crash with Safari 16.4 and 16.5
+  // https://github.com/tailwindlabs/tailwindcss/issues/17194
+  if (value === 'currentColor') {
+    return `oklab(from currentColor l a b / ${alpha})`
+  }
+
   return `color-mix(in oklab, ${value} ${alpha}, transparent)`
 }