diff --git a/docs/diffusion/quantization.md b/docs/diffusion/quantization.md
index 970b1ee5d743..4d876839ae35 100644
--- a/docs/diffusion/quantization.md
+++ b/docs/diffusion/quantization.md
@@ -1,6 +1,6 @@
 # Quantization
 
-SGLang-Diffusion supports quantized transformer checkpoints. In most cases, keep
+SGLang-Diffusion supports quantized transformer checkpoints and online quantization. In most cases, keep
 the base model and the quantized transformer override separate.
 
 ## Quick Reference
@@ -47,6 +47,7 @@ backend.
 | `modelopt-nvfp4`  | Mixed transformer directory/repo with `config.json`, or raw NVFP4 safetensors export/repo | `--transformer-path` for mixed overrides; `--transformer-weights-path` for raw exports | FLUX.1, FLUX.2, Wan2.2                  | None                                  | Mixed override repos keep the base model separate; raw exports such as `black-forest-labs/FLUX.2-dev-NVFP4` still use the weights-path flow |
 | `nunchaku-svdq`   | Pre-quantized Nunchaku transformer weights, usually named `svdq-{int4\|fp4}_r{rank}-...`   | `--transformer-weights-path`                                           | Model-specific support such as Qwen-Image, FLUX, and Z-Image | `nunchaku`                            | SGLang can infer precision and rank from the filename and supports both `int4` and `nvfp4`                                             |
 | `msmodelslim`     | Pre-quantized msmodelslim transformer weights                                              | `--model-path`                                                         | Wan2.2 family                           | None                                  | Currently only compatible with the Ascend NPU family and supports both `w8a8` and `w4a4`                                               |
+| `fp8 (online)`   | Any unquantized BF16 checkpoint                                                            | `--quantization fp8`                                                   | ALL                                     | None                                  | Online FP8 weight quantization at load time with dynamic activations                           |
 
 ## Validated ModelOpt Checkpoints
 
@@ -282,6 +283,37 @@ sglang generate \
 - Current runtime validation only allows Nunchaku on NVIDIA CUDA Ampere (SM8x)
   or SM12x GPUs. Hopper (SM90) is currently rejected.
 
+## Online Quantization
+
+SGLang-Diffusion supports online quantization of model weights at load
+time via the `--quantization` flag. This lets you run quantized inference
+from any BF16 checkpoint without a pre-converted or calibrated checkpoint.
+
+### Supported Methods
+
+| value | precision |
+|------------------------|-----------|
+| `fp8`                  | FP8 (E4M3) |
+
+### Usage Examples
+
+Apply online FP8 quantization to a FLUX model:
+
+```bash
+sglang generate \
+  --model-path black-forest-labs/FLUX.1-dev \
+  --quantization fp8 \
+  --prompt "A small cat" \
+  --save-output
+```
+
+### Notes
+
+- `--quantization` is independent of the checkpoint-based quantization.
+  It does not require `--transformer-path` or `--transformer-weights-path`.
+- When `--quantization` is set, it takes precedence over any quantization
+  config found in the checkpoint metadata.
+
 ## [ModelSlim](https://gitcode.com/Ascend/msmodelslim)
 MindStudio-ModelSlim (msModelSlim) is a model offline quantization compression tool launched by MindStudio and optimized for Ascend hardware.
 
diff --git a/python/sglang/multimodal_gen/runtime/loader/transformer_load_utils.py b/python/sglang/multimodal_gen/runtime/loader/transformer_load_utils.py
index 2f2057b8dd65..328476ebbac6 100644
--- a/python/sglang/multimodal_gen/runtime/loader/transformer_load_utils.py
+++ b/python/sglang/multimodal_gen/runtime/loader/transformer_load_utils.py
@@ -485,8 +485,19 @@ def _resolve_quant_config(
         arch_config, "reverse_param_names_mapping", None
     )
 
-    quant_config = get_quant_config(hf_config, component_model_path)
+    quant_config = get_quant_config(
+        hf_config, component_model_path, server_args=server_args
+    )
+    if quant_config is None and server_args.transformer_weights_path:
+        quant_config = _resolve_quant_config_from_transformer_override(
+            server_args.transformer_weights_path
+        )
+
     quant_config_name = _get_quant_config_name(quant_config)
+
+    if quant_config is not None and quant_config_name != "modelopt_fp4":
+        return quant_config
+
     inferred_nvfp4_config = None
     if quant_config is None or quant_config_name == "modelopt_fp4":
         fallback_group_size = None
@@ -498,13 +509,7 @@ def _resolve_quant_config(
             reverse_param_names_mapping_dict,
             fallback_group_size,
         )
-    quant_config = _merge_modelopt_fp4_configs(quant_config, inferred_nvfp4_config)
-    if quant_config is not None or not server_args.transformer_weights_path:
-        return quant_config
 
-    quant_config = _resolve_quant_config_from_transformer_override(
-        server_args.transformer_weights_path
-    )
     quant_config = _merge_modelopt_fp4_configs(quant_config, inferred_nvfp4_config)
     if quant_config is not None:
         return quant_config
diff --git a/python/sglang/multimodal_gen/runtime/server_args.py b/python/sglang/multimodal_gen/runtime/server_args.py
index cdc82c78f90d..4200a563781f 100644
--- a/python/sglang/multimodal_gen/runtime/server_args.py
+++ b/python/sglang/multimodal_gen/runtime/server_args.py
@@ -180,6 +180,8 @@ class ServerArgs(DisaggArgsMixin):
 
     # path to pre-quantized transformer weights (single .safetensors or directory).
     transformer_weights_path: str | None = None
+    # Online quantization method to apply
+    quantization: str | None = None
     # can restrict layers to adapt, e.g. ["q_proj"]
     # Will adapt only q, k, v, o by default.
     lora_target_modules: list[str] | None = None
@@ -1004,6 +1006,15 @@ def add_cli_args(parser: FlexibleArgumentParser) -> FlexibleArgumentParser:
             help="Disable autocast for denoising loop and vae decoding in pipeline sampling",
         )
 
+        parser.add_argument(
+            "--quantization",
+            type=str,
+            default=ServerArgs.quantization,
+            choices=["fp8"],
+            help="Apply online quantization to model weights. "
+            "Quantizes weights on-the-fly at load time, no pre-converted checkpoint needed.",
+        )
+
         # Nunchaku SVDQuant quantization parameters
         NunchakuSVDQuantArgs.add_cli_args(parser)
 
diff --git a/python/sglang/multimodal_gen/runtime/utils/quantization_utils.py b/python/sglang/multimodal_gen/runtime/utils/quantization_utils.py
index 2ddf2968739a..6715a93edcce 100644
--- a/python/sglang/multimodal_gen/runtime/utils/quantization_utils.py
+++ b/python/sglang/multimodal_gen/runtime/utils/quantization_utils.py
@@ -11,6 +11,8 @@
     QuantizationConfig,
     get_quantization_config,
 )
+from sglang.multimodal_gen.runtime.layers.quantization.fp8 import Fp8Config
+from sglang.multimodal_gen.runtime.server_args import ServerArgs
 from sglang.multimodal_gen.runtime.utils.logging_utils import init_logger
 
 logger = init_logger(__name__)
@@ -109,6 +111,16 @@ def find_quant_modelslim_config(model_config, component_model_path):
     return quant_cfg
 
 
+def resolve_online_quant_config(quantization_method: str) -> QuantizationConfig:
+    if quantization_method == "fp8":
+        logger.info("Online FP8 quantization enabled.")
+        return Fp8Config(
+            is_checkpoint_fp8_serialized=False,
+            activation_scheme="dynamic",
+        )
+    return None
+
+
 def replace_prefix(key: str, prefix_mapping: dict[str, str]) -> str:
     for prefix, new_prefix in prefix_mapping.items():
         if key.startswith(prefix):
@@ -121,7 +133,12 @@ def get_quant_config(
     component_model_path: str,
     packed_modules_mapping: Dict[str, List[str]] = {},
     remap_prefix: Dict[str, str] | None = None,
+    server_args: ServerArgs | None = None,
 ) -> QuantizationConfig:
+
+    if server_args and server_args.quantization:
+        return resolve_online_quant_config(server_args.quantization)
+
     quant_cfg = find_quant_modelslim_config(model_config, component_model_path)
     if quant_cfg is not None:
         quant_cls = _load_quant_cls(quant_cfg)