First, follow the Twilio Setup guide for creating a Twilio account and setting up environment variables with the proper credentials.
Then, initialize the Twilio Email Client.
import sendgrid
import os
mail_client = sendgrid.TwilioEmailAPIClient(os.environ.get('TWILIO_API_KEY'), os.environ.get('TWILIO_API_SECRET'))
# or
mail_client = sendgrid.TwilioEmailAPIClient(os.environ.get('TWILIO_ACCOUNT_SID'), os.environ.get('TWILIO_AUTH_TOKEN'))
This client has the same interface as the SendGridAPIClient
client.