diff --git a/pyproject.toml b/pyproject.toml
index cb97a9a2ce..b30fa276cf 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -69,7 +69,6 @@ scanpy = {version = ">=1.6", optional = true}
 scanpydoc = {version = ">=0.5", optional = true}
 scikit-learn = ">=0.21.2"
 scikit-misc = {version = ">=0.1.3", optional = true}
-setuptools = "<=59.5.0"
 sphinx = {version = ">=4.1,<4.4", optional = true}
 sphinx-autodoc-typehints = {version = "*", optional = true}
 sphinx-design = {version = "*", optional = true}