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Question about running pathways activity inference #142

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MigleMi opened this issue Oct 16, 2024 · 0 comments
Open

Question about running pathways activity inference #142

MigleMi opened this issue Oct 16, 2024 · 0 comments

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@MigleMi
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MigleMi commented Oct 16, 2024

Thank you for this cool tool!

I have a question regarding running pathways activity inference for scRNAseq data. I was wondering if it is only appropriate to run mlm method or also ok to run decoupleR::decouple. I tried both and seem to get a bit different results and even more what I would expect with using decoupleR::decouple with default parameters. Is that only ok to do for TF analysis or should I change something for pathway activity specifically?

Many thanks,
Migle

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