diff --git a/sisyphus/global_settings.py b/sisyphus/global_settings.py
index 19ae820..adf18f3 100644
--- a/sisyphus/global_settings.py
+++ b/sisyphus/global_settings.py
@@ -163,6 +163,10 @@ def file_caching(path):
 #: Default function to hash jobs and objects
 SIS_HASH = sisyphus.hash.short_hash
 
+#: Use the sis hash to compare Paths and to compute __hash__. The original behavior was not based on sis_hash
+#: which might lead to Paths with the same sis_hash to not be considered equal.
+USE_SIS_HASH_FOR_PATH_COMPARISON = False
+
 #: List of paths searched for loading config and recipe files. The module name should be part of the path e.g.:
 #: adding 'config' will cause Sisyphus to the current directory for a folder named config to load modules starting
 #: with config, other python files in the current directory will be ignored.
diff --git a/sisyphus/job_path.py b/sisyphus/job_path.py
index e155f74..4de6d70 100644
--- a/sisyphus/job_path.py
+++ b/sisyphus/job_path.py
@@ -192,6 +192,9 @@ def __lt__(self, other):
         if not isinstance(other, AbstractPath):
             assert False, "Cannot compare path to none path"
 
+        if gs.USE_SIS_HASH_FOR_PATH_COMPARISON:
+            return self._sis_hash() < other._sis_hash()
+
         def creator_to_str(c):
             if isinstance(c, str):
                 return c
@@ -214,14 +217,22 @@ def __eq__(self, other):
         if len(self.__dict__) == len(other.__dict__) == 0:
             return True
 
+        if gs.USE_SIS_HASH_FOR_PATH_COMPARISON:
+            return self._sis_hash() == other._sis_hash()
+
         creator_equal = self.creator == other.creator
         path_equal = self.path == other.path
         return creator_equal and path_equal
 
     def __hash__(self):
-        # TODO Check how uninitialized object should behave here
-        return hash((self.__dict__.get('creator'),
-                     self.__dict__.get('path')))
+        if gs.USE_SIS_HASH_FOR_PATH_COMPARISON:
+            if hasattr(self, 'creator'):  # uninitialized object have no creator and calling sis_hash would fail
+                # Add prefix to avoid collision with sis_hash string
+                return hash(b'HASH # ' + self._sis_hash())
+            else:
+                return super().__hash__()
+        else:
+            return hash((self.__dict__.get('creator'), self.__dict__.get('path')))
 
     def __getstate__(self):
         """  Skips exporting users