diff --git a/CHANGELOG.md b/CHANGELOG.md
index 8fadaa00..58772f3e 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -4,6 +4,7 @@
 
 ### Added
 ### Changed
+- [[#275](https://github.com/rust-vmm/vm-memory/pull/275)] Fail builds on non 64-bit platforms.
 ### Fixed
 ### Removed
 ### Deprecated
diff --git a/src/lib.rs b/src/lib.rs
index 6688b1d6..a9342235 100644
--- a/src/lib.rs
+++ b/src/lib.rs
@@ -20,6 +20,10 @@
 #![deny(missing_docs)]
 #![deny(missing_debug_implementations)]
 
+// We only support 64bit. Fail build when attempting to build other targets
+#[cfg(not(target_pointer_width = "64"))]
+compile_error!("vm-memory only supports 64-bit targets!");
+
 #[macro_use]
 pub mod address;
 pub use address::{Address, AddressValue};