diff --git a/compiler/rustc_llvm/build.rs b/compiler/rustc_llvm/build.rs
index 5be8bd466f854..ef262a5b19b08 100644
--- a/compiler/rustc_llvm/build.rs
+++ b/compiler/rustc_llvm/build.rs
@@ -160,6 +160,12 @@ impl<'a> IntoIterator for &'a LlvmConfigOutput {
     }
 }
 
+fn is_libstdcxx_cxx11_abi_flag(flag: &str) -> bool {
+    flag == "-D_GLIBCXX_USE_CXX11_ABI"
+        || flag.starts_with("-D_GLIBCXX_USE_CXX11_ABI=")
+        || flag == "-U_GLIBCXX_USE_CXX11_ABI"
+}
+
 fn main() {
     if cfg!(feature = "check_only") {
         return;
@@ -255,6 +261,14 @@ fn main() {
             continue;
         }
 
+        // This is a libstdc++ implementation detail for the C++ library that
+        // built the runnable llvm-config. When cross-compiling, target LLVM may
+        // have been built against a target libstdc++ with a different default.
+        // Let the target compiler/toolchain select its ABI instead.
+        if is_crossed && is_libstdcxx_cxx11_abi_flag(flag.as_ref()) {
+            continue;
+        }
+
         if flag.starts_with("-flto") {
             continue;
         }