diff --git a/compiler/rustc_hir_analysis/src/check/check.rs b/compiler/rustc_hir_analysis/src/check/check.rs
index 9ed083d16003c..ba4630c8b80a5 100644
--- a/compiler/rustc_hir_analysis/src/check/check.rs
+++ b/compiler/rustc_hir_analysis/src/check/check.rs
@@ -1633,6 +1633,16 @@ fn check_scalable_vector(tcx: TyCtxt<'_>, span: Span, def_id: LocalDefId, scalab
 pub(super) fn check_packed(tcx: TyCtxt<'_>, sp: Span, def: ty::AdtDef<'_>) {
     let repr = def.repr();
     if repr.packed() {
+        // `#[pin_v2]` on a packed type is unsound: drop glue for a packed type moves an
+        // over-aligned field to an aligned location before running its destructor, which would
+        // move a structurally pinned field out from under a `Pin<&mut _>` that was handed out.
+        if def.is_pin_project() {
+            tcx.dcx().emit_err(errors::PinV2OnPacked {
+                span: sp,
+                pin_v2_span: find_attr!(tcx, def.did(), PinV2(span) => *span),
+                adt_name: tcx.item_name(def.did()),
+            });
+        }
         if let Some(reprs) = find_attr!(tcx, def.did(), Repr { reprs, .. } => reprs) {
             for (r, _) in reprs {
                 if let ReprPacked(pack) = r
diff --git a/compiler/rustc_hir_analysis/src/errors.rs b/compiler/rustc_hir_analysis/src/errors.rs
index b968a626d398f..e7518e46e3654 100644
--- a/compiler/rustc_hir_analysis/src/errors.rs
+++ b/compiler/rustc_hir_analysis/src/errors.rs
@@ -2035,3 +2035,16 @@ pub(crate) struct PinV2WithoutPinDrop {
     pub pin_v2_span: Option<Span>,
     pub adt_name: Symbol,
 }
+
+#[derive(Diagnostic)]
+#[diag("`#[pin_v2]` types may not have `#[repr(packed)]`")]
+#[note(
+    "fields of a `#[repr(packed)]` type can be under-aligned, so a structurally pinned field may be moved to a properly aligned location, which `Pin` does not allow"
+)]
+pub(crate) struct PinV2OnPacked {
+    #[primary_span]
+    pub span: Span,
+    #[note("`{$adt_name}` is marked `#[pin_v2]` here")]
+    pub pin_v2_span: Option<Span>,
+    pub adt_name: Symbol,
+}
diff --git a/tests/ui/pin-ergonomics/pin_v2-packed.rs b/tests/ui/pin-ergonomics/pin_v2-packed.rs
new file mode 100644
index 0000000000000..b10c7565de0c9
--- /dev/null
+++ b/tests/ui/pin-ergonomics/pin_v2-packed.rs
@@ -0,0 +1,42 @@
+//! `#[pin_v2]` is not allowed on `#[repr(packed)]` types.
+//!
+//! Drop glue for a packed type moves an over-aligned field to an aligned location before running
+//! its destructor. That move carries along any structurally pinned leaf, so a value handed out as
+//! `Pin<&mut _>` would be moved before it is dropped, violating `Pin`'s invariant.
+//!
+//! Regression test for <https://github.com/rust-lang/rust/issues/157011>.
+
+#![feature(pin_ergonomics)]
+#![allow(incomplete_features)]
+
+use std::marker::PhantomPinned;
+
+#[pin_v2]
+#[repr(packed)]
+struct Packed { //~ ERROR `#[pin_v2]` types may not have `#[repr(packed)]`
+    field: PhantomPinned,
+}
+
+// The generic case from the issue: alignment of `T` is unknown at definition time, so this is
+// rejected regardless of how it is later monomorphized.
+#[pin_v2]
+#[repr(C, packed(4))]
+struct PackedN<T>(T);
+//~^ ERROR `#[pin_v2]` types may not have `#[repr(packed)]`
+
+#[pin_v2]
+#[repr(packed)]
+union PackedUnion { //~ ERROR `#[pin_v2]` types may not have `#[repr(packed)]`
+    field: (),
+}
+
+// Allowed: `#[pin_v2]` without `#[repr(packed)]` still compiles.
+#[pin_v2]
+#[repr(C)]
+struct Unpacked<T>(T);
+
+// Allowed: `#[repr(packed)]` without `#[pin_v2]` is unaffected by the ban.
+#[repr(packed)]
+struct PackedNoPin(u8);
+
+fn main() {}
diff --git a/tests/ui/pin-ergonomics/pin_v2-packed.stderr b/tests/ui/pin-ergonomics/pin_v2-packed.stderr
new file mode 100644
index 0000000000000..975b74e419687
--- /dev/null
+++ b/tests/ui/pin-ergonomics/pin_v2-packed.stderr
@@ -0,0 +1,41 @@
+error: `#[pin_v2]` types may not have `#[repr(packed)]`
+  --> $DIR/pin_v2-packed.rs:16:1
+   |
+LL | struct Packed {
+   | ^^^^^^^^^^^^^
+   |
+   = note: fields of a `#[repr(packed)]` type can be under-aligned, so a structurally pinned field may be moved to a properly aligned location, which `Pin` does not allow
+note: `Packed` is marked `#[pin_v2]` here
+  --> $DIR/pin_v2-packed.rs:14:1
+   |
+LL | #[pin_v2]
+   | ^^^^^^^^^
+
+error: `#[pin_v2]` types may not have `#[repr(packed)]`
+  --> $DIR/pin_v2-packed.rs:24:1
+   |
+LL | struct PackedN<T>(T);
+   | ^^^^^^^^^^^^^^^^^
+   |
+   = note: fields of a `#[repr(packed)]` type can be under-aligned, so a structurally pinned field may be moved to a properly aligned location, which `Pin` does not allow
+note: `PackedN` is marked `#[pin_v2]` here
+  --> $DIR/pin_v2-packed.rs:22:1
+   |
+LL | #[pin_v2]
+   | ^^^^^^^^^
+
+error: `#[pin_v2]` types may not have `#[repr(packed)]`
+  --> $DIR/pin_v2-packed.rs:29:1
+   |
+LL | union PackedUnion {
+   | ^^^^^^^^^^^^^^^^^
+   |
+   = note: fields of a `#[repr(packed)]` type can be under-aligned, so a structurally pinned field may be moved to a properly aligned location, which `Pin` does not allow
+note: `PackedUnion` is marked `#[pin_v2]` here
+  --> $DIR/pin_v2-packed.rs:27:1
+   |
+LL | #[pin_v2]
+   | ^^^^^^^^^
+
+error: aborting due to 3 previous errors
+