diff --git a/compiler/rustc_middle/src/mir/statement.rs b/compiler/rustc_middle/src/mir/statement.rs
index 48dcef298d66a..f66c4755de4dd 100644
--- a/compiler/rustc_middle/src/mir/statement.rs
+++ b/compiler/rustc_middle/src/mir/statement.rs
@@ -1050,11 +1050,12 @@ impl<'tcx> StmtDebugInfos<'tcx> {
         self.0.extend_from_slice(debuginfos);
     }
 
-    pub fn retain<F>(&mut self, f: F)
-    where
-        F: FnMut(&StmtDebugInfo<'tcx>) -> bool,
-    {
-        self.0.retain(f);
+    pub fn retain_locals(&mut self, locals: &DenseBitSet<Local>) {
+        self.retain(|debuginfo| match debuginfo {
+            StmtDebugInfo::AssignRef(local, _) | StmtDebugInfo::InvalidAssign(local) => {
+                locals.contains(*local)
+            }
+        });
     }
 }
 
diff --git a/compiler/rustc_mir_transform/src/single_use_consts.rs b/compiler/rustc_mir_transform/src/single_use_consts.rs
index 6d33736d64ecb..91e040d5cbc89 100644
--- a/compiler/rustc_mir_transform/src/single_use_consts.rs
+++ b/compiler/rustc_mir_transform/src/single_use_consts.rs
@@ -5,6 +5,8 @@ use rustc_middle::mir::visit::{MutVisitor, PlaceContext, Visitor};
 use rustc_middle::mir::*;
 use rustc_middle::ty::TyCtxt;
 
+use crate::strip_debuginfo::drop_invalid_debuginfos;
+
 /// Various parts of MIR building introduce temporaries that are commonly not needed.
 ///
 /// Notably, `if CONST` and `match CONST` end up being used-once temporaries, which
@@ -82,6 +84,8 @@ impl<'tcx> crate::MirPass<'tcx> for SingleUseConsts {
                 );
             }
         }
+
+        drop_invalid_debuginfos(body);
     }
 
     fn is_required(&self) -> bool {
diff --git a/compiler/rustc_mir_transform/src/strip_debuginfo.rs b/compiler/rustc_mir_transform/src/strip_debuginfo.rs
index 7fec25ccb5218..5931a46660241 100644
--- a/compiler/rustc_mir_transform/src/strip_debuginfo.rs
+++ b/compiler/rustc_mir_transform/src/strip_debuginfo.rs
@@ -32,24 +32,21 @@ impl<'tcx> crate::MirPass<'tcx> for StripDebugInfo {
             )
         });
 
-        let debuginfo_locals = debuginfo_locals(body);
-        for data in body.basic_blocks.as_mut_preserves_cfg() {
-            for stmt in data.statements.iter_mut() {
-                stmt.debuginfos.retain(|debuginfo| match debuginfo {
-                    StmtDebugInfo::AssignRef(local, _) | StmtDebugInfo::InvalidAssign(local) => {
-                        debuginfo_locals.contains(*local)
-                    }
-                });
-            }
-            data.after_last_stmt_debuginfos.retain(|debuginfo| match debuginfo {
-                StmtDebugInfo::AssignRef(local, _) | StmtDebugInfo::InvalidAssign(local) => {
-                    debuginfo_locals.contains(*local)
-                }
-            });
-        }
+        drop_invalid_debuginfos(body);
     }
 
     fn is_required(&self) -> bool {
         true
     }
 }
+
+// Drop invalid debuginfos when strip locals in `var_debug_info`.
+pub(super) fn drop_invalid_debuginfos(body: &mut Body<'_>) {
+    let debuginfo_locals = debuginfo_locals(body);
+    for data in body.basic_blocks.as_mut_preserves_cfg() {
+        for stmt in data.statements.iter_mut() {
+            stmt.debuginfos.retain_locals(&debuginfo_locals);
+        }
+        data.after_last_stmt_debuginfos.retain_locals(&debuginfo_locals);
+    }
+}
diff --git a/tests/mir-opt/debuginfo/single_use_consts.invalid_debuginfo.SingleUseConsts.diff b/tests/mir-opt/debuginfo/single_use_consts.invalid_debuginfo.SingleUseConsts.diff
new file mode 100644
index 0000000000000..09e9f26546a85
--- /dev/null
+++ b/tests/mir-opt/debuginfo/single_use_consts.invalid_debuginfo.SingleUseConsts.diff
@@ -0,0 +1,49 @@
+- // MIR for `invalid_debuginfo` before SingleUseConsts
++ // MIR for `invalid_debuginfo` after SingleUseConsts
+  
+  fn invalid_debuginfo() -> () {
+      let mut _0: ();
+      let _1: ();
+      scope 1 (inlined foo) {
+          let _2: ();
+          let mut _3: &isize;
+          let _4: &isize;
+          let _5: isize;
+          let mut _6: &isize;
+          scope 2 (inlined bar) {
+-             debug x => _4;
++             debug x => const foo::promoted[0];
+              let _7: isize;
+              let mut _9: &isize;
+              let _10: &isize;
+              scope 3 {
+-                 debug a => _7;
++                 debug a => const 1_isize;
+                  let mut _8: &isize;
+                  scope 4 {
+-                     debug z => _4;
++                     debug z => const foo::promoted[0];
+                  }
+              }
+          }
+      }
+  
+      bb0: {
+          StorageLive(_1);
+          StorageLive(_4);
+-         _4 = const foo::promoted[0];
++         nop;
+          StorageLive(_7);
+-         _7 = const 1_isize;
+-         // DBG: _4 = &_7;
++         nop;
+          StorageDead(_7);
+-         _1 = const ();
++         nop;
+          StorageDead(_4);
+          StorageDead(_1);
+          _0 = const ();
+          return;
+      }
+  }
+  
diff --git a/tests/mir-opt/debuginfo/single_use_consts.rs b/tests/mir-opt/debuginfo/single_use_consts.rs
new file mode 100644
index 0000000000000..eeae4cb7b81c5
--- /dev/null
+++ b/tests/mir-opt/debuginfo/single_use_consts.rs
@@ -0,0 +1,25 @@
+//@ test-mir-pass: SingleUseConsts
+//@ compile-flags: -g -Zinline-mir -Zmir-enable-passes=+InstSimplify-after-simplifycfg,+DeadStoreElimination-final,+DestinationPropagation -Zvalidate-mir
+//! Regression test for <https://github.com/rust-lang/rust/issues/33013>.
+
+#![crate_type = "lib"]
+
+// EMIT_MIR single_use_consts.invalid_debuginfo.SingleUseConsts.diff
+pub fn invalid_debuginfo() {
+    // CHECK-LABEL: fn invalid_debuginfo(
+    // CHEK: debug x => const
+    // CHEK: debug z => const
+    // CHECK-NOT: DBG
+    // CHECK: return
+    foo();
+}
+
+pub fn foo() {
+    bar(&1);
+}
+
+fn bar(x: &isize) {
+    let a = 1;
+    let mut z = x;
+    z = &a;
+}