diff --git a/compiler/rustc_borrowck/src/region_infer/opaque_types.rs b/compiler/rustc_borrowck/src/region_infer/opaque_types.rs
index 193b6d3e3d97a..d5875a226fe02 100644
--- a/compiler/rustc_borrowck/src/region_infer/opaque_types.rs
+++ b/compiler/rustc_borrowck/src/region_infer/opaque_types.rs
@@ -192,6 +192,11 @@ impl<'tcx> RegionInferenceContext<'tcx> {
                         .find(|ur_vid| self.eval_equal(vid, **ur_vid))
                         .and_then(|ur_vid| self.definitions[*ur_vid].external_name)
                         .unwrap_or(infcx.tcx.lifetimes.re_erased),
+                    ty::RePlaceholder(_) => ty::Region::new_error_with_message(
+                        infcx.tcx,
+                        concrete_type.span,
+                        "hidden type contains placeholders, we don't support higher kinded opaques yet",
+                    ),
                     _ => region,
                 });
             debug!(?universal_concrete_type);
diff --git a/tests/ui/type-alias-impl-trait/hkl_forbidden4.rs b/tests/ui/type-alias-impl-trait/hkl_forbidden4.rs
new file mode 100644
index 0000000000000..ef9fe604ea783
--- /dev/null
+++ b/tests/ui/type-alias-impl-trait/hkl_forbidden4.rs
@@ -0,0 +1,25 @@
+//! This test used to ICE because, while an error was emitted,
+//! we still tried to remap generic params used in the hidden type
+//! to the ones of the opaque type definition.
+
+//@ edition: 2021
+
+#![feature(type_alias_impl_trait)]
+use std::future::Future;
+
+type FutNothing<'a> = impl 'a + Future<Output = ()>;
+//~^ ERROR: unconstrained opaque type
+
+async fn operation(_: &mut ()) -> () {
+    //~^ ERROR: concrete type differs from previous
+    call(operation).await
+}
+
+async fn call<F>(_f: F)
+where
+    for<'any> F: FnMut(&'any mut ()) -> FutNothing<'any>,
+{
+    //~^ ERROR: expected generic lifetime parameter, found `'any`
+}
+
+fn main() {}
diff --git a/tests/ui/type-alias-impl-trait/hkl_forbidden4.stderr b/tests/ui/type-alias-impl-trait/hkl_forbidden4.stderr
new file mode 100644
index 0000000000000..d7a0452727e83
--- /dev/null
+++ b/tests/ui/type-alias-impl-trait/hkl_forbidden4.stderr
@@ -0,0 +1,34 @@
+error: unconstrained opaque type
+  --> $DIR/hkl_forbidden4.rs:10:23
+   |
+LL | type FutNothing<'a> = impl 'a + Future<Output = ()>;
+   |                       ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
+   |
+   = note: `FutNothing` must be used in combination with a concrete type within the same module
+
+error: concrete type differs from previous defining opaque type use
+  --> $DIR/hkl_forbidden4.rs:13:1
+   |
+LL | async fn operation(_: &mut ()) -> () {
+   | ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ expected `FutNothing<'_>`, got `{async fn body@$DIR/hkl_forbidden4.rs:13:38: 16:2}`
+   |
+note: previous use here
+  --> $DIR/hkl_forbidden4.rs:15:5
+   |
+LL |     call(operation).await
+   |     ^^^^^^^^^^^^^^^
+
+error[E0792]: expected generic lifetime parameter, found `'any`
+  --> $DIR/hkl_forbidden4.rs:21:1
+   |
+LL |   type FutNothing<'a> = impl 'a + Future<Output = ()>;
+   |                   -- this generic parameter must be used with a generic lifetime parameter
+...
+LL | / {
+LL | |
+LL | | }
+   | |_^
+
+error: aborting due to 3 previous errors
+
+For more information about this error, try `rustc --explain E0792`.