diff --git a/compiler/rustc_hir_analysis/locales/en-US.ftl b/compiler/rustc_hir_analysis/locales/en-US.ftl
index 40b5bc2a32e83..636953ecb00b0 100644
--- a/compiler/rustc_hir_analysis/locales/en-US.ftl
+++ b/compiler/rustc_hir_analysis/locales/en-US.ftl
@@ -125,6 +125,8 @@ hir_analysis_where_clause_on_main = `main` function is not allowed to have a `wh
 hir_analysis_track_caller_on_main = `main` function is not allowed to be `#[track_caller]`
     .suggestion = remove this annotation
 
+hir_analysis_target_feature_on_main = `main` function is not allowed to have `#[target_feature]`
+
 hir_analysis_start_not_track_caller = `start` is not allowed to be `#[track_caller]`
     .label = `start` is not allowed to be `#[track_caller]`
 
diff --git a/compiler/rustc_hir_analysis/src/errors.rs b/compiler/rustc_hir_analysis/src/errors.rs
index 203e0f85cad54..34b0d4ea08a70 100644
--- a/compiler/rustc_hir_analysis/src/errors.rs
+++ b/compiler/rustc_hir_analysis/src/errors.rs
@@ -315,6 +315,14 @@ pub(crate) struct TrackCallerOnMain {
     pub annotated: Span,
 }
 
+#[derive(Diagnostic)]
+#[diag(hir_analysis_target_feature_on_main)]
+pub(crate) struct TargetFeatureOnMain {
+    #[primary_span]
+    #[label(hir_analysis_target_feature_on_main)]
+    pub main: Span,
+}
+
 #[derive(Diagnostic)]
 #[diag(hir_analysis_start_not_track_caller)]
 pub(crate) struct StartTrackCaller {
diff --git a/compiler/rustc_hir_analysis/src/lib.rs b/compiler/rustc_hir_analysis/src/lib.rs
index 33c132fd5349b..6015272c06f1a 100644
--- a/compiler/rustc_hir_analysis/src/lib.rs
+++ b/compiler/rustc_hir_analysis/src/lib.rs
@@ -283,6 +283,11 @@ fn check_main_fn_ty(tcx: TyCtxt<'_>, main_def_id: DefId) {
         error = true;
     }
 
+    if !tcx.codegen_fn_attrs(main_def_id).target_features.is_empty() {
+        tcx.sess.emit_err(errors::TargetFeatureOnMain { main: main_span });
+        error = true;
+    }
+
     if error {
         return;
     }
diff --git a/tests/ui/asm/x86_64/issue-89875.rs b/tests/ui/asm/x86_64/issue-89875.rs
index e793690ddbed9..07a31cd20c576 100644
--- a/tests/ui/asm/x86_64/issue-89875.rs
+++ b/tests/ui/asm/x86_64/issue-89875.rs
@@ -5,7 +5,7 @@
 use std::arch::asm;
 
 #[target_feature(enable = "avx")]
-fn main() {
+fn foo() {
     unsafe {
         asm!(
             "/* {} */",
@@ -13,3 +13,5 @@ fn main() {
         );
     }
 }
+
+fn main() {}
diff --git a/tests/ui/rfcs/rfc-2396-target_feature-11/issue-108645-target-feature-on-main.rs b/tests/ui/rfcs/rfc-2396-target_feature-11/issue-108645-target-feature-on-main.rs
new file mode 100644
index 0000000000000..413b5c332ffa9
--- /dev/null
+++ b/tests/ui/rfcs/rfc-2396-target_feature-11/issue-108645-target-feature-on-main.rs
@@ -0,0 +1,5 @@
+// only-x86_64
+
+#[target_feature(enable = "avx2")]
+fn main() {}
+//~^ ERROR `main` function is not allowed to have `#[target_feature]`
diff --git a/tests/ui/rfcs/rfc-2396-target_feature-11/issue-108645-target-feature-on-main.stderr b/tests/ui/rfcs/rfc-2396-target_feature-11/issue-108645-target-feature-on-main.stderr
new file mode 100644
index 0000000000000..2f01663d8192e
--- /dev/null
+++ b/tests/ui/rfcs/rfc-2396-target_feature-11/issue-108645-target-feature-on-main.stderr
@@ -0,0 +1,8 @@
+error: `main` function is not allowed to have `#[target_feature]`
+  --> $DIR/issue-108645-target-feature-on-main.rs:4:1
+   |
+LL | fn main() {}
+   | ^^^^^^^^^ `main` function is not allowed to have `#[target_feature]`
+
+error: aborting due to previous error
+