diff --git a/requirements.txt b/requirements.txt
index 002352d6..1de74620 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -18,4 +18,4 @@ fastapi[all] == 0.103.1
 urllib3 >= 1.26.6
 
 # Testing Requirements
-nest_asyncio == 1.5.7
+nest_asyncio == 1.5.8
diff --git a/runpod/serverless/utils/rp_upload.py b/runpod/serverless/utils/rp_upload.py
index af6ce4cc..f56484ae 100644
--- a/runpod/serverless/utils/rp_upload.py
+++ b/runpod/serverless/utils/rp_upload.py
@@ -18,11 +18,24 @@
 from boto3.s3.transfer import TransferConfig
 from botocore.config import Config
 from tqdm_loggable.auto import tqdm
+from urllib.parse import urlparse
 
 logger = logging.getLogger("runpod upload utility")
 FMT = "%(filename)-20s:%(lineno)-4d %(asctime)s %(message)s"
 logging.basicConfig(level=logging.INFO, format=FMT, handlers=[logging.StreamHandler()])
 
+def extract_region_from_url(endpoint_url):
+    parsed_url = urlparse(endpoint_url)
+    # AWS/backblaze S3-like URL
+    if '.s3.' in endpoint_url:
+        return endpoint_url.split('.s3.')[1].split('.')[0]
+    # DigitalOcean Spaces-like URL
+    elif parsed_url.netloc.endswith('.digitaloceanspaces.com'):
+        return endpoint_url.split('.')[1].split('.digitaloceanspaces.com')[0]
+    else:
+        # Additional cases can be added here
+        return None
+  
 
 # --------------------------- S3 Bucket Connection --------------------------- #
 def get_boto_client(
@@ -57,12 +70,16 @@ def get_boto_client(
         secret_access_key = os.environ.get('BUCKET_SECRET_ACCESS_KEY', None)
 
     if endpoint_url and access_key_id and secret_access_key:
+        # Extract region from the endpoint URL
+        region = extract_region_from_url(endpoint_url)
+        
         boto_client = bucket_session.client(
             's3',
             endpoint_url=endpoint_url,
             aws_access_key_id=access_key_id,
             aws_secret_access_key=secret_access_key,
-            config=boto_config
+            config=boto_config,
+            region_name=region
         )
     else:
         boto_client = None
diff --git a/tests/test_serverless/test_utils/test_upload.py b/tests/test_serverless/test_utils/test_upload.py
index e36f67e6..ef3b0e28 100644
--- a/tests/test_serverless/test_utils/test_upload.py
+++ b/tests/test_serverless/test_utils/test_upload.py
@@ -58,7 +58,8 @@ def test_get_boto_client(self):
                 endpoint_url=bucket_creds['endpointUrl'],
                 aws_access_key_id=bucket_creds['accessId'],
                 aws_secret_access_key=bucket_creds['accessSecret'],
-                config=unittest.mock.ANY
+                config=unittest.mock.ANY,
+                region_name=None
             )
 
     def test_get_boto_client_environ(self):