diff --git a/pyquil/_parser/grammar.lark b/pyquil/_parser/grammar.lark
index 4993172c3..5f0b93a62 100644
--- a/pyquil/_parser/grammar.lark
+++ b/pyquil/_parser/grammar.lark
@@ -60,7 +60,7 @@ def_circuit : "DEFCIRCUIT" name [ variables ] [ qubit_designators ] ":" indented
 //             | "DEFCIRCUIT" name [ variables ] qubit_designators ":" indented_instrs -> def_circuit_qubits
 
 def_frame : "DEFFRAME" frame ( ":" frame_spec+ )?
-frame_spec : _NEWLINE_TAB frame_attr ":" (expression | "\"" name "\"" )
+frame_spec : _NEWLINE_TAB frame_attr ":" (expression | string )
 !frame_attr : "SAMPLE-RATE"
             | "INITIAL-FREQUENCY"
             | "DIRECTION"
diff --git a/pyquil/_parser/parser.py b/pyquil/_parser/parser.py
index b8984ea4b..0b345fdc7 100644
--- a/pyquil/_parser/parser.py
+++ b/pyquil/_parser/parser.py
@@ -142,6 +142,9 @@ def def_frame(self, frame, *specs):
         for (spec_name, spec_value) in specs:
             name = names.get(spec_name, None)
             if name:
+                if isinstance(spec_value, str) and spec_value[0] == '"' and spec_value[-1] == '"':
+                    # Strip quotes if necessary
+                    spec_value = spec_value[1:-1]
                 options[name] = spec_value
             else:
                 raise ValueError(
diff --git a/test/unit/test_parser.py b/test/unit/test_parser.py
index 9cd241c41..16b190bd8 100644
--- a/test/unit/test_parser.py
+++ b/test/unit/test_parser.py
@@ -684,3 +684,14 @@ def test_parse_defgate_as_pauli():
 )
 def test_parse_comments(program):
     Program(program)
+
+
+def test_parse_strings_with_spaces():
+    Program(str(Program("""
+DEFFRAME 0 "readout_tx":
+    DIRECTION: "tx"
+    INITIAL-FREQUENCY: 7220000000.0
+    CENTER-FREQUENCY: 7125000000
+    HARDWARE-OBJECT: "A_string_with_one space"
+    SAMPLE-RATE: 1000000000.0
+""")))