diff --git a/docs/usage/key-concepts/minimum-release-age.md b/docs/usage/key-concepts/minimum-release-age.md
index e7b524c2cc6..277df1dc4eb 100644
--- a/docs/usage/key-concepts/minimum-release-age.md
+++ b/docs/usage/key-concepts/minimum-release-age.md
@@ -44,6 +44,13 @@ To protect against this, it's recommended to ensure that your package manager co
 There is ongoing work to [integrate more closely with package manager checks](https://github.com/renovatebot/renovate/issues/41652) to make sure that Renovate's minimum release age configuration is specified when calling package managers that support it.
 If you have a package manager you'd like supported, please raise a [Suggest an Idea Discussion](https://github.com/renovatebot/renovate/discussions/new?category=suggest-an-idea).
 
+#### uv
+
+<!-- prettier-ignore -->
+For uv, Renovate reads `[tool.uv] exclude-newer` from `pyproject.toml` and uses the more restrictive (older) date between it and `minimumReleaseAge`.
+The `exclude-newer` value can be an RFC 3339 timestamp (e.g. `2025-01-01T00:00:00Z`) or a friendly duration (e.g. `2 weeks`), but ISO 8601 durations (e.g. `P14D`) are not supported.
+See uv's [dependency bot integration guide](https://docs.astral.sh/uv/guides/integration/dependency-bots/#dependency-cooldown) for details on configuring `exclude-newer`.
+
 ### What happens if the datasource and/or registry does not provide a release timestamp, when using `minimumReleaseAge`?
 
 <!-- prettier-ignore -->
diff --git a/lib/modules/manager/pep621/processors/uv.spec.ts b/lib/modules/manager/pep621/processors/uv.spec.ts
index 90b9452989a..21866a69702 100644
--- a/lib/modules/manager/pep621/processors/uv.spec.ts
+++ b/lib/modules/manager/pep621/processors/uv.spec.ts
@@ -891,5 +891,210 @@ describe('modules/manager/pep621/processors/uv', () => {
         },
       ]);
     });
+
+    describe('UV_EXCLUDE_NEWER with minimumReleaseAge', () => {
+      let execSnapshots: ReturnType<typeof mockExecAll>;
+
+      beforeEach(() => {
+        vi.useFakeTimers();
+        vi.setSystemTime(new Date('2026-03-13T00:00:00.000Z'));
+        execSnapshots = mockExecAll();
+        GlobalConfig.set(adminConfig);
+        fs.findLocalSiblingOrParent.mockResolvedValueOnce('uv.lock');
+        fs.readLocalFile.mockResolvedValueOnce('test content');
+        fs.readLocalFile.mockResolvedValueOnce('changed test content');
+        getPkgReleases.mockResolvedValueOnce({
+          releases: [{ version: '3.11.1' }],
+        });
+        getPkgReleases.mockResolvedValueOnce({
+          releases: [{ version: '0.2.35' }],
+        });
+      });
+
+      afterEach(() => {
+        vi.restoreAllMocks();
+        vi.useRealTimers();
+      });
+
+      it('sets UV_EXCLUDE_NEWER from minimumReleaseAge', async () => {
+        await processor.updateArtifacts(
+          {
+            packageFileName: 'folder/pyproject.toml',
+            newPackageFileContent: '',
+            config: {
+              isLockFileMaintenance: true,
+              minimumReleaseAge: '3 days',
+            },
+            updatedDeps: [],
+          },
+          parsePyProject('')!,
+        );
+        expect(execSnapshots[0].options?.env).toMatchObject({
+          UV_EXCLUDE_NEWER: '2026-03-10T00:00:00.000Z',
+        });
+      });
+
+      it('sets UV_EXCLUDE_NEWER for non-maintenance upgrade-package command', async () => {
+        const updatedDeps = [
+          { packageName: 'dep1', depType: depTypes.dependencies },
+        ];
+        await processor.updateArtifacts(
+          {
+            packageFileName: 'folder/pyproject.toml',
+            newPackageFileContent: '',
+            config: {
+              minimumReleaseAge: '3 days',
+            },
+            updatedDeps,
+          },
+          parsePyProject('')!,
+        );
+        expect(execSnapshots[0].cmd).toBe('uv lock --upgrade-package dep1');
+        expect(execSnapshots[0].options?.env).toMatchObject({
+          UV_EXCLUDE_NEWER: '2026-03-10T00:00:00.000Z',
+        });
+      });
+
+      it('skips UV_EXCLUDE_NEWER when minimumReleaseAge absent', async () => {
+        await processor.updateArtifacts(
+          {
+            packageFileName: 'folder/pyproject.toml',
+            newPackageFileContent: '',
+            config: { isLockFileMaintenance: true },
+            updatedDeps: [],
+          },
+          parsePyProject('')!,
+        );
+        expect(execSnapshots[0].options?.env?.UV_EXCLUDE_NEWER).toBeUndefined();
+      });
+
+      it('skips UV_EXCLUDE_NEWER when minimumReleaseAgeBehaviour is timestamp-optional', async () => {
+        await processor.updateArtifacts(
+          {
+            packageFileName: 'folder/pyproject.toml',
+            newPackageFileContent: '',
+            config: {
+              isLockFileMaintenance: true,
+              minimumReleaseAge: '3 days',
+              minimumReleaseAgeBehaviour: 'timestamp-optional',
+            },
+            updatedDeps: [],
+          },
+          parsePyProject('')!,
+        );
+        expect(execSnapshots[0].options?.env?.UV_EXCLUDE_NEWER).toBeUndefined();
+      });
+
+      it('skips UV_EXCLUDE_NEWER on unparseable minimumReleaseAge', async () => {
+        await processor.updateArtifacts(
+          {
+            packageFileName: 'folder/pyproject.toml',
+            newPackageFileContent: '',
+            config: {
+              isLockFileMaintenance: true,
+              minimumReleaseAge: 'invalid garbage',
+            },
+            updatedDeps: [],
+          },
+          parsePyProject('')!,
+        );
+        expect(execSnapshots[0].options?.env?.UV_EXCLUDE_NEWER).toBeUndefined();
+        expect(logger.logger.debug).toHaveBeenCalledWith(
+          "Invalid minimumReleaseAge value 'invalid garbage', skipping UV_EXCLUDE_NEWER for uv lock",
+        );
+      });
+
+      it('uses pyproject ISO date when more restrictive', async () => {
+        const pyproject = parsePyProject(codeBlock`
+          [tool.uv]
+          exclude-newer = "2026-03-05T00:00:00.000Z"
+        `)!;
+        await processor.updateArtifacts(
+          {
+            packageFileName: 'folder/pyproject.toml',
+            newPackageFileContent: '',
+            config: {
+              isLockFileMaintenance: true,
+              minimumReleaseAge: '3 days',
+            },
+            updatedDeps: [],
+          },
+          pyproject,
+        );
+        expect(execSnapshots[0].options?.env).toMatchObject({
+          UV_EXCLUDE_NEWER: '2026-03-05T00:00:00.000Z',
+        });
+      });
+
+      it('uses minimumReleaseAge when pyproject less restrictive', async () => {
+        const pyproject = parsePyProject(codeBlock`
+          [tool.uv]
+          exclude-newer = "2026-03-12T00:00:00.000Z"
+        `)!;
+        await processor.updateArtifacts(
+          {
+            packageFileName: 'folder/pyproject.toml',
+            newPackageFileContent: '',
+            config: {
+              isLockFileMaintenance: true,
+              minimumReleaseAge: '3 days',
+            },
+            updatedDeps: [],
+          },
+          pyproject,
+        );
+        expect(execSnapshots[0].options?.env).toMatchObject({
+          UV_EXCLUDE_NEWER: '2026-03-10T00:00:00.000Z',
+        });
+      });
+
+      it('uses pyproject relative duration when more restrictive', async () => {
+        const pyproject = parsePyProject(codeBlock`
+          [tool.uv]
+          exclude-newer = "2 weeks"
+        `)!;
+        await processor.updateArtifacts(
+          {
+            packageFileName: 'folder/pyproject.toml',
+            newPackageFileContent: '',
+            config: {
+              isLockFileMaintenance: true,
+              minimumReleaseAge: '3 days',
+            },
+            updatedDeps: [],
+          },
+          pyproject,
+        );
+        // 2 weeks = 14 days ago = 2026-02-27, which is older than 3 days ago = 2026-03-10
+        expect(execSnapshots[0].options?.env).toMatchObject({
+          UV_EXCLUDE_NEWER: '2026-02-27T00:00:00.000Z',
+        });
+      });
+
+      it('ignores unparseable pyproject exclude-newer and uses minimumReleaseAge', async () => {
+        const pyproject = parsePyProject(codeBlock`
+          [tool.uv]
+          exclude-newer = "not-a-date"
+        `)!;
+        await processor.updateArtifacts(
+          {
+            packageFileName: 'folder/pyproject.toml',
+            newPackageFileContent: '',
+            config: {
+              isLockFileMaintenance: true,
+              minimumReleaseAge: '3 days',
+            },
+            updatedDeps: [],
+          },
+          pyproject,
+        );
+        expect(execSnapshots[0].options?.env).toMatchObject({
+          UV_EXCLUDE_NEWER: '2026-03-10T00:00:00.000Z',
+        });
+        expect(logger.logger.debug).toHaveBeenCalledWith(
+          "Invalid exclude-newer value 'not-a-date' in pyproject.toml, ignoring",
+        );
+      });
+    });
   });
 });
diff --git a/lib/modules/manager/pep621/processors/uv.ts b/lib/modules/manager/pep621/processors/uv.ts
index fe023092a53..5f61868cf9d 100644
--- a/lib/modules/manager/pep621/processors/uv.ts
+++ b/lib/modules/manager/pep621/processors/uv.ts
@@ -1,4 +1,5 @@
-import { isString } from '@sindresorhus/is';
+import { isNullOrUndefined, isString } from '@sindresorhus/is';
+import { DateTime } from 'luxon';
 import { quote } from 'shlex';
 import { TEMPORARY_ERROR } from '../../../../constants/error-messages.ts';
 import { logger } from '../../../../logger/index.ts';
@@ -14,6 +15,7 @@ import {
 } from '../../../../util/fs/index.ts';
 import { getGitEnvironmentVariables } from '../../../../util/git/auth.ts';
 import { find } from '../../../../util/host-rules.ts';
+import { toMs } from '../../../../util/pretty-time.ts';
 import { Result } from '../../../../util/result.ts';
 import { parseUrl } from '../../../../util/url.ts';
 import { PypiDatasource } from '../../../datasource/pypi/index.ts';
@@ -215,6 +217,48 @@ export class UvProcessor extends BasePyProjectProcessor {
       } else {
         cmd = generateCMD(updatedDeps);
       }
+
+      // See https://docs.astral.sh/uv/guides/integration/dependency-bots/#dependency-cooldown
+      // Skip UV_EXCLUDE_NEWER when minimumReleaseAgeBehaviour is 'timestamp-optional',
+      // as simple API doesn't return releaseTimestamp and the user opted out of requiring it
+      if (
+        config.minimumReleaseAge &&
+        config.minimumReleaseAgeBehaviour !== 'timestamp-optional'
+      ) {
+        const ms = toMs(config.minimumReleaseAge);
+        if (isNullOrUndefined(ms)) {
+          logger.debug(
+            `Invalid minimumReleaseAge value '${config.minimumReleaseAge}', skipping UV_EXCLUDE_NEWER for uv lock`,
+          );
+        } else {
+          let excludeNewerDate = DateTime.now().minus(ms).toUTC();
+
+          const pyprojectExcludeNewer = project.tool?.uv?.['exclude-newer'];
+          if (pyprojectExcludeNewer) {
+            let pyprojectDate = DateTime.fromISO(pyprojectExcludeNewer, {
+              zone: 'utc',
+            });
+            if (!pyprojectDate.isValid) {
+              const durationMs = toMs(pyprojectExcludeNewer);
+              if (!isNullOrUndefined(durationMs)) {
+                pyprojectDate = DateTime.now().minus(durationMs).toUTC();
+              }
+            }
+            if (pyprojectDate.isValid) {
+              if (pyprojectDate < excludeNewerDate) {
+                excludeNewerDate = pyprojectDate;
+              }
+            } else {
+              logger.debug(
+                `Invalid exclude-newer value '${pyprojectExcludeNewer}' in pyproject.toml, ignoring`,
+              );
+            }
+          }
+
+          extraEnv.UV_EXCLUDE_NEWER = excludeNewerDate.toISO();
+        }
+      }
+
       await exec(cmd, execOptions);
 
       // check for changes
diff --git a/lib/modules/manager/pep621/schema.spec.ts b/lib/modules/manager/pep621/schema.spec.ts
new file mode 100644
index 00000000000..966ddce8c26
--- /dev/null
+++ b/lib/modules/manager/pep621/schema.spec.ts
@@ -0,0 +1,16 @@
+import { PyProject } from './schema.ts';
+
+describe('modules/manager/pep621/schema', () => {
+  describe('UvConfig', () => {
+    it('handles exclude-newer as Date object', () => {
+      const result = PyProject.parse({
+        tool: {
+          uv: { 'exclude-newer': new Date('2026-03-05T00:00:00.000Z') },
+        },
+      });
+      expect(result.tool?.uv?.['exclude-newer']).toBe(
+        '2026-03-05T00:00:00.000Z',
+      );
+    });
+  });
+});
diff --git a/lib/modules/manager/pep621/schema.ts b/lib/modules/manager/pep621/schema.ts
index d9e345fe64f..0b3a4503fe5 100644
--- a/lib/modules/manager/pep621/schema.ts
+++ b/lib/modules/manager/pep621/schema.ts
@@ -152,6 +152,9 @@ const UvConfig = z.object({
   'dev-dependencies': LooseArray(
     Pep508Dependency(depTypes.uvDevDependencies),
   ).catch([]),
+  'exclude-newer': z
+    .union([z.string(), z.date().transform((d) => d.toISOString())])
+    .optional(),
   'required-version': z.string().optional(),
   sources: LooseRecord(
     // uv applies the same normalization as for Python dependencies on sources
diff --git a/lib/modules/manager/types.ts b/lib/modules/manager/types.ts
index 0be4c0775f8..30047bd0817 100644
--- a/lib/modules/manager/types.ts
+++ b/lib/modules/manager/types.ts
@@ -1,6 +1,7 @@
 import type { ReleaseType } from 'semver';
 import type {
   MatchStringsStrategy,
+  MinimumReleaseAgeBehaviour,
   ToolSettingsOptions,
   UpdateType,
   ValidationMessage,
@@ -9,6 +10,7 @@ import type { Category } from '../../constants/index.ts';
 import type {
   MaybePromise,
   ModuleApi,
+  Nullish,
   RangeStrategy,
   SkipReason,
   StageName,
@@ -50,6 +52,8 @@ export interface UpdateArtifactsConfig {
   skipArtifactsUpdate?: boolean;
   lockFiles?: string[];
   toolSettings?: ToolSettingsOptions;
+  minimumReleaseAge?: Nullish<string>;
+  minimumReleaseAgeBehaviour?: MinimumReleaseAgeBehaviour;
 }
 
 export interface RangeConfig<T = Record<string, any>> extends ManagerData<T> {